Skip to content
Snippets Groups Projects
Commit 764ccc35 authored by Kang Wang's avatar Kang Wang
Browse files

code_9.30(未添加表格)

parent 0873d2dc
No related branches found
No related tags found
No related merge requests found
Pipeline #473188 passed
......@@ -964,58 +964,7 @@ export function Model() {
</div>
</div>
<p>To identify knockout targets, we ran FBA optimization on iDK1463, yielding the flux values for various metabolic reactions in the optimized strain. Next, we filtered out the reactions related to ammonia, excluding those with a flux of zero under normal physiological conditions. The biomass reaction and reactions linearly related to it were considered essential and not selected as targets. Ultimately, among the **6 reactions identified**, the flux of ammonia-producing reactions will be minimized, while the flux of ammonia-consuming reactions will be maximized.</p>
<table style="border-collapse:collapse; border:none;">
<tr>
<th style="border-top: double; text-align:center; font-style:italic; font-weight:normal; padding:0.2cm; border-bottom:1px solid black; text-align:left; ">ID</th>
<th style="border-top: double; text-align:center; font-style:italic; font-weight:normal; padding:0.2cm; border-bottom:1px solid black; ">Name</th>
<th style="border-top: double; text-align:center; font-style:italic; font-weight:normal; padding:0.2cm; border-bottom:1px solid black; ">Formula</th>
<th style="border-top: double; text-align:center; font-style:italic; font-weight:normal; padding:0.2cm; border-bottom:1px solid black; ">Flux..mmol..gDW.hr..</th>
<th style="border-top: double; text-align:center; font-style:italic; font-weight:normal; padding:0.2cm; border-bottom:1px solid black; ">Strategy</th>
</tr>
<tr>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:left; ">CBMKr</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Carbamate kinase</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">{"atp_c + co2_c + nh4_c <=> adp_c + cbp_c + 2.0 h_c"}</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">0.55</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Maximize</td>
</tr>
<tr>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:left; ">GMPS</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">GMP synthase</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">{"atp_c + nh4_c + xmp_c --> amp_c + gmp_c + 2.0 h_c + ppi_c"}</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">0.21</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Maximize</td>
</tr>
<tr>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:left; ">ASNS2</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Asparagine synthetase</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">{"asp__L_c + atp_c + nh4_c -->amp_c + asn__L_c + h_c + ppi_c"}</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">0.21</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Maximize</td>
</tr>
<tr>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:left; ">GLYCL</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Glycine Cleavage System</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">{"gly_c + nad_c + thf_c --'{'>'}' co2_c + mlthf_c + nadh_c + nh4_c"}</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">0.05</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Minimize</td>
</tr>
<tr>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:left; ">TRPAS2</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Tryptophanase (L-tryptophan)</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">{"h2o_c + trp__L_c <=> indole_c + nh4_c + pyr_c"}</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">-0.05</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Minimize</td>
</tr>
<tr>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:left; border-bottom: double; ">GLUDy</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; border-bottom: double; ">Glutamate dehydrogenase (NADP)</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; border-bottom: double; ">{"glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c"}</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; border-bottom: double; ">-7.53</td>
<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; border-bottom: double; ">Minimize</td>
</tr>
</table>
<h3>2.3 Target Gene Search Based on Evolutionary Algorithms</h3>
......
0% Loading or .
You are about to add 0 people to the discussion. Proceed with caution.
Finish editing this message first!
Please register or to comment