From 764ccc350b45855cb57297ebc2f877e3e3168850 Mon Sep 17 00:00:00 2001
From: Kang Wang <888666wang4286@gmail.com>
Date: Mon, 30 Sep 2024 10:26:54 +0000
Subject: [PATCH] =?UTF-8?q?code=5F9.30(=E6=9C=AA=E6=B7=BB=E5=8A=A0?=
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src/contents/model.tsx | 53 +-----------------------------------------
1 file changed, 1 insertion(+), 52 deletions(-)
diff --git a/src/contents/model.tsx b/src/contents/model.tsx
index 5e55979..f494a28 100644
--- a/src/contents/model.tsx
+++ b/src/contents/model.tsx
@@ -964,58 +964,7 @@ export function Model() {
</div>
</div>
<p>To identify knockout targets, we ran FBA optimization on iDK1463, yielding the flux values for various metabolic reactions in the optimized strain. Next, we filtered out the reactions related to ammonia, excluding those with a flux of zero under normal physiological conditions. The biomass reaction and reactions linearly related to it were considered essential and not selected as targets. Ultimately, among the **6 reactions identified**, the flux of ammonia-producing reactions will be minimized, while the flux of ammonia-consuming reactions will be maximized.</p>
- <table style="border-collapse:collapse; border:none;">
-<tr>
-<th style="border-top: double; text-align:center; font-style:italic; font-weight:normal; padding:0.2cm; border-bottom:1px solid black; text-align:left; ">ID</th>
-<th style="border-top: double; text-align:center; font-style:italic; font-weight:normal; padding:0.2cm; border-bottom:1px solid black; ">Name</th>
-<th style="border-top: double; text-align:center; font-style:italic; font-weight:normal; padding:0.2cm; border-bottom:1px solid black; ">Formula</th>
-<th style="border-top: double; text-align:center; font-style:italic; font-weight:normal; padding:0.2cm; border-bottom:1px solid black; ">Flux..mmol..gDW.hr..</th>
-<th style="border-top: double; text-align:center; font-style:italic; font-weight:normal; padding:0.2cm; border-bottom:1px solid black; ">Strategy</th>
-</tr>
-<tr>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:left; ">CBMKr</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Carbamate kinase</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">{"atp_c + co2_c + nh4_c <=> adp_c + cbp_c + 2.0 h_c"}</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">0.55</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Maximize</td>
-</tr>
-<tr>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:left; ">GMPS</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">GMP synthase</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">{"atp_c + nh4_c + xmp_c --> amp_c + gmp_c + 2.0 h_c + ppi_c"}</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">0.21</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Maximize</td>
-</tr>
-<tr>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:left; ">ASNS2</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Asparagine synthetase</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">{"asp__L_c + atp_c + nh4_c -->amp_c + asn__L_c + h_c + ppi_c"}</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">0.21</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Maximize</td>
-</tr>
-<tr>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:left; ">GLYCL</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Glycine Cleavage System</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">{"gly_c + nad_c + thf_c --'{'>'}' co2_c + mlthf_c + nadh_c + nh4_c"}</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">0.05</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Minimize</td>
-</tr>
-<tr>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:left; ">TRPAS2</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Tryptophanase (L-tryptophan)</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">{"h2o_c + trp__L_c <=> indole_c + nh4_c + pyr_c"}</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">-0.05</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; ">Minimize</td>
-</tr>
-<tr>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:left; border-bottom: double; ">GLUDy</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; border-bottom: double; ">Glutamate dehydrogenase (NADP)</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; border-bottom: double; ">{"glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c"}</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; border-bottom: double; ">-7.53</td>
-<td style=" padding:0.2cm; text-align:left; vertical-align:top; text-align:center; border-bottom: double; ">Minimize</td>
-</tr>
-</table>
-
+
<h3>2.3 Target Gene Search Based on Evolutionary Algorithms</h3>
--
GitLab