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<p>My symptoms began in 2017, with stomach cramps that left me too ill to perform every couple of months. As the pain intensified, I realized something was seriously wrong. Every IBD patient endures significant suffering, and I am no exception. Yet, I refuse to let my illness waste my life.</p>
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<imgsrc="https://static.igem.wiki/teams/5187/wiki-home-fig/pic3.png"alt="IBD Patient Story 3">
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<p>I consider myself a fortunate IBD patient, as I've remained in remission. Unlike many others on strict diets, I enjoy a varied diet, avoiding only spicy foods and caffeine. My doctor recommends enteral nutritional powder to address potential deficiencies and advises not to stray too far from the hospital. However, I make my own choices. I even participated in an exchange program in the U.S. Thanks to Tsinghua University's medication subsidies, which alleviate my financial burdens. Aside from regular check-ups, life is generally good.</p>
<p>During our brainstorm for treating IBD, we were inspired by the wisdom of our ancestor. A non-invasive, convenient and aromatic medication is what the Chinese IBD patient could use of. We introduced a muscone detecting switch in the engineered yeast and activated the downstream pathway to express lactate dehydrogenase to produce lactic acid. Ultimately, the engineered bacteria will colonize the small intestine, enabling the patient to treat IBD by inhaling muscone gas in vitro therefore induces the yeast to synthesize a low amount of stabilized lactic acid in vivo.</p>