<p>We hope to improve the treatment experience for IBD patients, so we have chosen gas signals as the therapeutic switch for the engineered bacterial secretion system. Drawing inspiration from the research of the Ye Haifeng team<sup>[1]</sup>, we selected the muscone molecular receptor they developed and designed it to be transferred into <i>Saccharomyces cerevisiae</i>, to create an engineered <i>Saccharomyces cerevisiae</i> muscone molecular switch.</p>
<p>The muscone receptor is a G protein-coupled receptor derived from mouse olfactory epithelial cells, and we need to integrate the muscone receptor with the existing G protein signaling pathway in <i>Saccharomyces cerevisiae</i>. Referencing the research of the Benjamin M Scott team<sup>[2]</sup>, we have modified the signaling pathways in <i>Saccharomyces cerevisiae</i> according to their operational methods and achieved the creation of a muscone molecular switch in this model organism.</p>
<p>For more information, please refer to <ahref="https://2024.igem.wiki/Tsinghua/description"style="color: #FF5151">Description</a>.</p>