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Zhefu Li
Tsinghua
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3871ab68
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3871ab68
authored
6 months ago
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Zhefu Li
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@@ -159,6 +159,65 @@
of Life Sciences. The school currently has 129 professors and employees, around 600 undergraduates
(including the candidates of Tsinghua University – Peking Union Medical College joint MD program).
</p>
<h3>
Model Equations
</h3>
<h4>
Inhalation Equation for Muscone
</h4>
<p>
\( V_{\text{inhale}}(t) =\frac{Q_{\text{inhale}}}{5}(u(t)-u(t-5)) \)
</p>
<p><strong>
Explanation
</strong>
:This describes the rate equation for inhaling muscone over five seconds,
where the total amount \( Q \) remains constant. The function \( u(t) \) is a step function, which
takes the value of \( \frac{Q_{\text{inhale}}}{5} \) from \( t=0s \) to \( t=5s \), and is \( 0 \)
otherwise, simulating the scenario of resting human respiration.
</p>
<h4>
Compartment 0: \( Q_A(t) \)
</h4>
<p>
\( \frac{dQ_A(t)}{dt} = V_{\text{inhale}}(t) - \left( k_{\text{exhale}} + k_{\text{perm}} \right)
Q_A(t) \)
</p>
<p><strong>
Explanation
</strong>
: The amount of muscone in the alveoli increases through inhalation and
decreases due to exhalation, adhesion to the respiratory mucosa, and permeation into the alveolar
capillaries.
</p>
<p><strong>
Parameters
</strong>
:
</p>
<ul>
<li>
\( k_{\text{exhale}} \): Since most of the muscone is rapidly exhaled, this value is relatively
large, taken as \( 10 \ \text{min}^{-1} \)
</li>
<li>
\( k_{\text{perm}} \): The rate of muscone permeation into the capillaries, affected by its
physicochemical properties, is taken as \( 0.005 \ \text{min}^{-1} \)
</li>
</ul>
<h4>
Compartment 1: \( Q_M(t) \)
</h4>
<p>
\( \frac{dQ_M(t)}{dt} = 0.0005 \cdot k_{\text{adh}} V_{\text{inhale}}(t) - k_{\text{diffMC}} Q_M(t)
\)
</p>
<p><strong>
Explanation
</strong>
: The increase in muscone on the mucosa comes from adhesion in the
alveoli, and the decrease is due to diffusion into the systemic circulation.
</p>
<p><strong>
Parameters
</strong>
:
</p>
<ul>
<li>
\( k_{\text{adh}} \): The adhesion process is relatively slow, and only \( 0.5\% \) of muscone
enters the systemic circulation through this pathway, taken as \( 0.001 \ \text{min}^{-1} \)
</li>
<li>
\( k_{\text{diffMC}} \): Diffusion from the mucosa to the systemic circulation is slow, taken as
\( 0.01 \ \text{min}^{-1} \)
</li>
</ul>
</div>
</div>
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