<p>In addition, we have produced a popular science manual aimed at popularizing scientific knowledge and improving the scientific literacy of the public. The manual provides a detailed introduction to the basic concepts, symptoms, and causes of Inflammatory Bowel Disease (IBD), helping readers understand this complex medical issue and thereby raising awareness for early recognition and treatment. At the same time, it explains the scientific principles involved in the diagnosis and treatment of IBD, such as blood tests and imaging examinations, enhancing readers' understanding of the medical process. Furthermore, the manual delves into synthetic biology and the iGEM competition, stimulating interest in this emerging field of science, and showcases the application of synthetic biology in the treatment of IBD, such as the "MuScure"project,highlightingitsinnovationandpotentialeffectiveness.ThemanualalsodescribestheworkflowoftheiGEMteam,conveyingthebasicmethodsofscientificresearchandcultivatingreaders'scientificthinkingandproblem-solvingabilities.ByshowcasingthepracticalapplicationsoftheTsinghuaiGEMteam,themanualencouragesreaderstoconsidertheapplicationofscientificprinciplesindailylifeandcareerdevelopment.Visualelementssuchaschartsandflowchartshelpreadersunderstandcomplexconceptsmoreintuitively,andtheprovidedcontactinformationencouragesinteractionandfurtherexplorationofscientificknowledge.Insummary,thismanual,withitsrichcontentanddiverseforms,notonlyprovidesknowledgeaboutIBDandsyntheticbiologybutalsostimulatesthepublic'sinterestinscience,playingasignificantroleinenhancingscientificliteracyandeducationlevels.</p>