Newer
Older
<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="UTF-8">
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<link rel="icon" type="image/x-icon" href="https://static.igem.wiki/teams/5187/art/icon.png">
<title>Inclusivity | Tsinghua - IGEM 2024</title>
line-height: 1.6;
margin: 0;
padding: 0;
}
.content {
padding: 20px;
max-width: 800px;
margin: 0 auto;
}
.row.mt-4 {
margin-right: 100px;
margin-left: 130px;
<div class="row mt-4">
<div class="col-lg-12">
<p>Synthetic biology empowers us with the ability to assemble complex biological systems much like assembling building blocks, with biological parts at the heart of this assembly process. Against this backdrop, we offer a glimpse into the diverse array of components utilized in the MuSecure project.</p>
<p>Among these components, you will find foundational elements that serve as the cornerstone of our work. For instance, we employ some basic parts, including MOR215 (<a href="https://parts.igem.org/Part:BBa_K5187000" style="color: #FF5151;">BBa_K5187000</a>), Gα (<a href="https://parts.igem.org/Part:BBa_K5187001" style="color: #FF5151;">BBa_K5187001</a>), pFUS1 promoter (<a href="https://parts.igem.org/Part:BBa_K5187002" style="color: #FF5151;">BBa_K5187002</a>), and ldhA (<a href="https://parts.igem.org/Part:BBa_K5187003" style="color: #FF5151;">BBa_K5187003</a>), to construct the core design of MuSecure.</p>
<p>Furthermore, we would like to highlight our impressive Muscone-gated molecular switch in Saccharomyces cerevisiae (<a href="https://parts.igem.org/Part:BBa_K5187006" style="color: #FF5151;">BBa_K5187006</a>), which was pioneered and characterized by Tsinghua University in 2024. This system forms the core of our project and holds great potential for widespread applications in the field of synthetic biology.</p>
<p>Our components have been designed to integrate muscone induction and the therapeutic capabilities of lactate. These parts embody our collective effort and wisdom, enabling us to achieve success in the laboratory work of our project.</p>
<div class="table-container">
<h3 class="table-title">Table 1. Basic Parts</h3>
<table class="w-full border-collapse" style="background-color: #FFE4E1; border: 1px solid black;">
<tr class="bg-gray-200">
<th class="border border-gray-300 p-2">Part name</th>
<th class="border border-gray-300 p-2">Part type</th>
<th class="border border-gray-300 p-2">Short description</th>
</tr>
<tr>
<td class="border border-gray-300 p-2">BBa_K5187000</td>
<td class="border border-gray-300 p-2">Protein Domain</td>
<td class="border border-gray-300 p-2">MOR215-1: Receptor of Muscone</td>
</tr>
<tr>
<td class="border border-gray-300 p-2">BBa_K5187001</td>
<td class="border border-gray-300 p-2">Protein Domain</td>
<td class="border border-gray-300 p-2">GPA1-GNAI3: Synthetic Gα protein that responds to MOR215-1</td>
</tr>
<tr>
<td class="border border-gray-300 p-2">BBa_K5187002</td>
<td class="border border-gray-300 p-2">Regulatory</td>
<td class="border border-gray-300 p-2">pFUS1: Downstream promoter for our artificial signaling pathway</td>
</tr>
<tr>
<td class="border border-gray-300 p-2">BBa_K5187003</td>
<td class="border border-gray-300 p-2">Protein Domain</td>
<td class="border border-gray-300 p-2">ldhA: lactate dehydrogenase</td>
</tr>
<tr>
<td class="border border-gray-300 p-2">BBa_K5187004</td>
<td class="border border-gray-300 p-2">Protein Domain</td>
<td class="border border-gray-300 p-2">ALS3: an adhesion protein</td>
</tr>
<tr>
<td class="border border-gray-300 p-2">BBa_K5187005</td>
<td class="border border-gray-300 p-2">Regulatory</td>
<td class="border border-gray-300 p-2">GAL1, 10 promoter: Bidirectional promoter</td>
</tr>
<div class="table-container">
<h3 class="table-title">Table 2. Composite Parts</h3>
<table class="w-full border-collapse" style="background-color: #FFE4E1; border: 1px solid black; margin-top: 20px;">
<tr class="bg-gray-200">
<th class="border border-gray-300 p-2">Part name</th>
<th class="border border-gray-300 p-2">Part type</th>
<th class="border border-gray-300 p-2">Short description</th>
</tr>
<tr>
<td class="border border-gray-300 p-2">BBa_K5187006</td>
<td class="border border-gray-300 p-2">Composite</td>
<td class="border border-gray-300 p-2">Muscone-gated molecular switch in Saccharomyces cerevisiae</td>
</tr>
<tr>
<td class="border border-gray-300 p-2">BBa_K5187009</td>
<td class="border border-gray-300 p-2">Composite</td>
<td class="border border-gray-300 p-2">Tetrathionate Sensing Colonization System</td>
</tr>
<p>Our aspiration extends beyond our immediate project goals. We envision these meticulously designed parts not only playing a pivotal role in advancing our project but also making significant contributions to the broader iGEM community and the ongoing development of synthetic biology as a comprehensive discipline.</p>