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    <h2>what are we doing for?</h2>
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    <p>Inflammatory Bowel Disease (IBD) is an indeterminate colitis and autoimmune inflammatory bowel disease that involves the ileum, rectum, and colon. Due to its unknown pathogenesis, it is difficult to cure and prone to relapse, which is then referred to as the “green cancer”. As the incidence of IBD is increasing globally, the poor therapeutic experience, which the patients are required to receive long-term hormone injection and biologic combination therapy, is determined to seek a breakthrough. Our team stands to develop a more favorable treatment experience. Relevant studies have shown that lactic acid has an inhibitory effect on abnormally activated dendritic cells and cytotoxic T-cells in autoimmune diseases, and thus is expected to improve the symptoms of IBD patients. Based on the research, we designed a yeast engineered bacterium. We introduced a muscone detecting switch in the engineered yeast and activated the downstream pathway to express lactate dehydrogenase to produce lactic acid. Ultimately, the engineered bacteria will colonize the small intestine, enabling the patient to treat IBD by inhaling muscone gas in vitro therefore induces the yeast to synthesize a low amount of stabilized lactic acid in vivo. Aroma therapy has the potential to be a new trend in long-term treatment for IBD as it can reduce the discomfort of treatment and improve the long-term treatment experience. </p>
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    <img src="https://static.igem.wiki/teams/5187/figure/ibd-figure.jpg" alt="ibd_figure" style="max-width: 100%; height: auto; width: 50%;">
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    <h2>What should this page contain?</h2>
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    <ul>
      <li>A clear and concise description of your project.</li>
      <li>A detailed explanation of why your team chose to work on this particular project.</li>
      <li>References and sources to document your research.</li>
      <li>Use illustrations and other visual resources to explain your project.</li>
    </ul>
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    <h2>Inspirations</h2>
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    <ul>
      <li><a href="https://2022.igem.wiki/dtu-denmark/description">2022 DTU-Denmark</a></li>
      <li><a href="https://2019.igem.org/Team:ITESO_Guadalajara/Description">2019 ITESO Guadalajara</a></li>
      <li><a href="https://2020.igem.org/Team:Technion-Israel/Description">2020 Technion Israel</a></li>
      <li><a href="https://2020.igem.org/Team:Botchan_Lab_Tokyo/Description">2020 Botchan Lab Tokyo</a></li>
      <li><a href="https://2020.igem.org/Team:St_Andrews/Description">2020 St Andrews</a></li>
      <li><a href="https://2020.igem.org/Team:MIT/Description">2020 MIT</a></li>
    </ul>
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    <h2>Some advice</h2>
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    <p>We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be concise, accurate, and unambiguous in your achievements. Your Project Description should include more information than your project abstract.</p>
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    <h2>References</h2>
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    <p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.</p>
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