<h4class="mb-4">Main key contributions: A part collection</h4>
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<p>WOur iGEM project focuses on developing microbial strains capable of producing glycoproteins decorated with glycan structures, particularly Man3GlcNAc2, which is essential for therapeutic proteins. We have worked on both yeast and E. coli systems for glycoprotein production, as well as introducing new strategies to enhance glycosylation efficiency using archaeal enzymes. We are contributing several engineered parts, including oligosaccharyltransferase and glucocerebrosidase genes that can be helpful to other iGEMs teams, which have been optimized for expression in various microbial hosts. This collection of parts will be useful for research into glycosylation and the production of therapeutic enzymes.</p>
<p>Our iGEM project focuses on developing microbial strains capable of producing glycoproteins decorated with glycan structures, particularly Man3GlcNAc2, which is essential for therapeutic proteins. We have worked on both yeast and E. coli systems for glycoprotein production, as well as introducing new strategies to enhance glycosylation efficiency using archaeal enzymes. We are contributing several engineered parts, including oligosaccharyltransferase and glucocerebrosidase genes that can be helpful to other iGEMs teams, which have been optimized for expression in various microbial hosts. This collection of parts will be useful for research into glycosylation and the production of therapeutic enzymes.</p>
