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Commit 90481233 authored by Xujinsheng's avatar Xujinsheng
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<p>
<b>Programmable Logic Devices (PLDs)</b> are engineering chips that can be manually reconfigured after
<b>Programmable Logic Devices (PLDs)</b> are chips that can be manually reconfigured after
manufacturing, enabling them to perform a variety of logic functions. Inspired by PLDs, we have designed a
programmable synthetic biology framework, LANTERN, which allows users to customize logic gates tailored to
their specific scenarios.
specific scenarios.
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With the help of recombinases and CRISPRi, LANTERN can <b>switch between different types of logic gates based on
user requirements</b>. <b>Recombinases</b> are used as tools to reprogram the circuits, while <b>CRISPRi
functions</b>
as a NOT gate. By simply adjusting the inputs and outputs according to specific needs, LANTERN can be
reconfigured into virtually any desired logic gate.
</p>
<p><strong>Recombinases</strong> are used as tools to reprogram the circuits, while <strong>CRISPRi
functions</strong> as a NOT gate. LANTERN can be then reconfigured into virtually any desired logic gate by
simply adjusting the inputs and outputs according to specific needs.</p>
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<p>
LANTERN introduces the concept of <b>"programmable pathway synthetic biology"</b>, addressing the need to construct
and customize various logical relationships in the lab with potential applications in industrial
manufacturing. Drawing inspiration from PLDs in electrical engineering, LANTERN bridges the gap between
engineering and bioengineering. <b>This represents what we want to contribute to the iGEM community —
harnessing engineering principles to uncover the mysteries of biology.</b>
</p>
<p>LANTERN introduces the concept of &quot;programmable pathways,&quot; addressing the need to construct and
customize various logical relationships in the lab with potential applications in industrial manufacturing.
Drawing inspiration from PLDs in electrical engineering, this also represents the ideology we want to convey
to the iGEM community — <em>harnessing engineering principles to uncover the mysteries of biology</em>.</p>
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<img src="https://static.igem.wiki/teams/5276/wiki/pages/homepage/new-logic-gates.png" alt="placeholder"
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Why the name <b>LANTERN</b>?
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The digits "0" and "1" are fundamental to logic gates, and we noticed that their shapes can perfectly form the
pattern of a traditional Chinese lantern. This inspired us to name our system LANTERN, symbolizing both its
foundation in logic and its connection to cultural heritage.
</p>
<p>The digits &quot;0&quot; and &quot;1&quot; are fundamental to logic gates, and we noticed that their shapes
can perfectly form the pattern of a traditional Chinese lantern. This inspired us to name our system LANTERN,
symbolizing both its foundation in logic and its connection to cultural heritage.</p>
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<img src="https://static.igem.wiki/teams/5276/wiki/pages/homepage/whitelogo.png" alt="placeholder" id="p2image">
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