<p>Biosafety is an important part of project design. In the case of Muscure, a clinical application project, we primarily focus on project safety design from four aspects: biological design, production, transportation, and use.</p>
<p>We have also consulted relevant professionals regarding project safety. To learn more, enter Human Practices. </p>
<p>According to our design, therapeutic engineered yeast will be produced in a large-scale specialized microbiological facility. Specialized facilities must have the appropriate equipment and trained personnel. What’s more, the laboratory and premises during the production process must adhere to international biosafety standards and ensure strict biosafety levels, such as BSL-2 or BSL-3. The cultivation of Saccharomyces cerevisiae must take place in controlled bioreactors to minimize the risk of leakage. Personnel must undergo specialized training and strictly follow operating procedures, including wearing protective gear and using biosafety cabinets. Waste must be handled and disposed of in accordance with the standards for biohazardous waste to prevent any leakage of biological materials.</p>
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<h3>Transportation</h3>
<p>We consider the transportation process to be one of the most crucial aspects of biosafety in bacterial therapy projects. After thorough investigation and research, we have determined that using lyophilized yeast powder for transportation is the optimal choice. Lyophilized yeast powder has the advantage of being transported at room temperature without loss of activity. Moreover, such yeasts are less prone to leakage and contamination.</p>
<p>During transportation, double-sealed containers should be employed to minimize the risk of bacterial leakage. Continuous monitoring must be carried out throughout the transportation process to ensure that no leakage or contamination occurs.</p>
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<h3>Use</h3>
<p>For patients, they must use this strain under the guidance of a medical professional or pharmacist and inhale muscone as prescribed. Patients undergoing the therapy must undergo regular monitoring to detect any potential adverse reactions or leaks.</p>
<p>For hospitals, the handling of engineered yeasts is also crucial. Healthcare professionals, including doctors and nurses, should receive specialized training to understand the proper use of engineered yeasts. Hospitals should also procure specialized equipment for storing or resuscitating these strains. Additionally, medical waste such as syringes used during treatment should be separately disinfected to prevent the leakage of engineered yeasts into the environment.</p>
