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Commit dcd89f5d authored by Xingan Zhao's avatar Xingan Zhao
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Merge branch 'main' of https://gitlab.igem.org/2024/smu-gdmu-china 

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src/contents/model.tsx
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......@@ -59,7 +59,7 @@ const SideNavbar: React.FC<SideNavbarProps> = ({ activeLink }) => {
<Nav className="flex-column">
<Nav.Link as={Link} to="section1" smooth={true} duration={500} className={activeLink === 'section1' ? 'active' : 'notActive'}>ODE Model of Biochemical Reactions</Nav.Link>
<Nav.Link as={Link} to="section2" smooth={true} duration={500} className={activeLink === 'section2' ? 'active' : 'notActive'}>Metabolic Engineering Strategy to Reduce Ammonia Production</Nav.Link>
<Nav.Link as={Link} to="section3" smooth={true} duration={500} className={activeLink === 'section3' ? 'active' : 'notActive'}>part3</Nav.Link>
{/* 添加更多导航链接 */}
......@@ -143,21 +143,19 @@ export function Model() {
<MathJax.Provider>
<div className='indent formula_content' >
<span className='formula_line'><MathJax.Node formula={`{PEA_{gut}\\overset{k_{\\text{diff}}\\_{\\text{PEA}}}{\\underset{k_{\\text{diff}}\\_{\\text{PEA}}}{\\rightleftharpoons}} PEA_{peri}}`} /> </span>
<span className='formula_number'>1</span>
<span className='formula_number'>(1)</span>
</div>
</MathJax.Provider>
<p>According to the law of mass action, this process can be represented by an ordinary differential equation (ODE) as follows</p>
<MathJax.Provider>
<div className='indent formula_content' >
<span className='formula_line'> <MathJax.Node formula={`\\frac{\\mathrm{d}[PEA_{peri}]}{\\mathrm{d}t} = \\frac{k_{diff\\_PEA}}{V_{peri}}([PEA_{gut}] - [PEA_{peri}])`} /> </span>
<span className='formula_number'>2</span>
<span className='formula_number'>(2)</span>
</div>
<div className='indent formula_content'>
<span className='formula_line'> <MathJax.Node formula={`\\frac{\\mathrm{d}[PEA_{gut}]}{\\mathrm{d}t} = \\frac{k_{diff\\_PEA}}{V_{gut}}([PEA_{peri}] - [PEA_{gut}])`} /> </span>
<span className='formula_number'>3</span>
</div>
<span className='formula_number'>(3)</span> </div>
</MathJax.Provider>
<p>where <MathJax.Provider>
......@@ -169,8 +167,7 @@ export function Model() {
<MathJax.Provider>
<div className='indent formula_content'>
<span className='formula_line'><MathJax.Node formula={` PEA\\xrightarrow[K_{M\\_TynA},k_{cat\\_TynA}]{TynA} PA_{peri} + NH_{3\\_peri}`} /> </span>
<span className='formula_number'>4</span>
</div>
<span className='formula_number'>(4)</span> </div>
</MathJax.Provider>
<p>The Michaelis-Menten mechanism describes the enzymatic conversion of a substrate <MathJax.Provider>
<span>
......@@ -190,8 +187,7 @@ export function Model() {
<MathJax.Provider>
<div className='indent formula_content'>
<span className='formula_line'><MathJax.Node formula={`{{E+S}\\overset{k_{f1}}{\\underset{k_{r1}}{\\rightleftharpoons}} ES \\xrightarrow[]{k_{cat}}E + P}`} /> </span>
<span className='formula_number'>5</span>
</div>
<span className='formula_number'>(5)</span> </div>
</MathJax.Provider>
<p>where <MathJax.Provider>
<span>
......@@ -221,13 +217,11 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`k_{f1}[E][S] = \\left( k_{r1} + k_{\\mathrm{cat}} \\right) [ES]`} /> </span>
<span className='formula_number'>6</span>
</div>
<span className='formula_number'>(6)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`[ES] = \\frac{ k_{f1}[E][S] }{ k_{r1} + k_{\\mathrm{cat}} }`} /> </span>
<span className='formula_number'>7</span>
</div>
<span className='formula_number'>(7)</span> </div>
</MathJax.Provider>
......@@ -236,8 +230,7 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`[E_{\\text{total}}] = [E] + [ES]`} /> </span>
<span className='formula_number'>8</span>
</div>
<span className='formula_number'>(8)</span> </div>
</MathJax.Provider>
<p>Substitute <MathJax.Provider>
<span>
......@@ -255,8 +248,7 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`[ES] = \\frac{[E_{\\text{total}}] [S]}{\\frac{k_{r1} + k_{\\text{cat}}}{k_{f1}} + [S]}`} /> </span>
<span className='formula_number'>9</span>
</div>
<span className='formula_number'>(9)</span> </div>
</MathJax.Provider>
<p>The Michaelis constant <MathJax.Provider>
<span>
......@@ -268,8 +260,7 @@ export function Model() {
<span className='formula_line'>
<MathJax.Node formula={`K_M = \\frac{k_{r1} + k_{\\text{cat}}}{k_{f1}}
`} /> </span>
<span className='formula_number'>10</span>
</div>
<span className='formula_number'>(10)</span> </div>
</MathJax.Provider>
<p>This simplifies the expression for to</p>
......@@ -278,7 +269,7 @@ export function Model() {
<span className='formula_line'>
<MathJax.Node formula={`ES = \\frac{ {[E\\_total][S]} }{K_M + [S]}`} /> </span>
<span className='formula_number'>11</span> </div>
<span className='formula_number'>(11)</span> </div>
</MathJax.Provider>
<p>The rate of product formation is
......@@ -287,8 +278,7 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`v_0 = k_{cat}[ES]`} /> </span>
<span className='formula_number'>12</span>
</div>
<span className='formula_number'>(12)</span> </div>
</MathJax.Provider>
<p>Substituting <MathJax.Provider>
<span>
......@@ -300,8 +290,7 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`v_0 = \\frac{V_{max}[s]}{K_M+[S]}`} /> </span>
<span className='formula_number'>13</span>
</div>
<span className='formula_number'>(13)</span> </div>
</MathJax.Provider>
<p>where <MathJax.Provider>
......@@ -331,20 +320,17 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[PA_{peri}]}{\\mathrm{d}t} = \\frac{k_{cat\\_TynA}[TynA][PEA_{peri}]}{K_{M\\_TynA}+[PEA_{peri}]}`} /></span>
<span className='formula_number'>14</span>
<span className='formula_number'>(14)</span>
</div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[NH_{3\\_peri}]}{\\mathrm{d}t} = \\frac{k_{cat\\_TynA}[TynA][PEA_{peri}]}{K_{M\\_TynA}+[PEA_{peri}]}`} /> </span>
<span className='formula_number'>15</span>
<span className='formula_number'>(15)</span>
</div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[PEA_{peri}]}{\\mathrm{d}t} = -\\frac{k_{cat\\_TynA}[TynA][PEA_{peri}]}{K_{M\\_TynA}+[PEA_{peri}]}`} /></span>
<span className='formula_number'>16</span>
<span className='formula_number'>(16)</span>
</div>
</MathJax.Provider>
......@@ -353,14 +339,12 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`PA_{peri}\\overset{}{\\underset{}{\\rightleftharpoons}}PA_{cyto}`} /></span>
<span className='formula_number'>17</span>
<span className='formula_number'>(17)</span>
</div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`NH_{3\\_peri}\\overset{}{\\underset{}{\\rightleftharpoons}}NH_{3\\_cyto}`} /> </span>
<span className='formula_number'>18</span>
<span className='formula_number'>(18)</span>
</div>
</MathJax.Provider>
<p>According to the law of mass action</p>
......@@ -368,26 +352,22 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[PA_{cyto}]}{\\mathrm{d}t} = \\frac{k_{diff\\_PA}}{V_{cyto}}([PA_{peri}]-[PA_{cyto}])`} /></span>
<span className='formula_number'>19</span>
<span className='formula_number'>(19)</span>
</div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[PA_{peri}]}{\\mathrm{d}t} = \\frac{k_{diff\\_PA}}{V_{peri}}([PA_{cyto}]-[PA_{peri}])`} /> </span>
<span className='formula_number'>20</span>
<span className='formula_number'>(20)</span>
</div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[NH_{3\\_cyto}]}{\\mathrm{d}t} = \\frac{k_{diff\\_NH3}}{V_{cyto}}([NH_{3\\_peri}]-[NH_{3\\_cyto}])`} /></span>
<span className='formula_number'>21</span>
<span className='formula_number'>(21)</span>
</div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[NH_{3\\_peri}]}{\\mathrm{d}t} = \\frac{k_{diff\\_NH3}}{V_{peri}}([NH_{3\\_cyto}]-[NH_{3\\_peri}])`} /> </span>
<span className='formula_number'>22</span>
<span className='formula_number'>(22)</span>
</div>
</MathJax.Provider>
......@@ -398,20 +378,17 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`FeaR+PA_{cyto}\\overset{}{\\underset{}{\\rightleftharpoons}}FearR-PA`} /></span>
<span className='formula_number'>23</span>
<span className='formula_number'>(23)</span>
</div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`FeaR-PA\\xrightarrow{}FearR+PAA_{cyto}`} /> </span>
<span className='formula_number'>24</span>
<span className='formula_number'>(24)</span>
</div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`PAA_{cyto}\\overset{}{\\underset{}{\\rightleftharpoons}}PAA_{gut}`} /></span>
<span className='formula_number'>25</span>
<span className='formula_number'>(25)</span>
</div>
</MathJax.Provider>
<p>The FeaR-phenylacetaldehyde complex can bind and activate the PTynA promoter. In this case, the concentration of the enzyme-substrate complex <MathJax.Provider>
......@@ -439,8 +416,7 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`K_M = \\frac{k_{r1}+k_{cat}}{k_{f1}}`} /></span>
<span className='formula_number'>26</span>
<span className='formula_number'>(26)</span>
</div>
</MathJax.Provider>
......@@ -484,8 +460,7 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`k_{f1} \\approx \\frac{k_{cat}}{K_m}`} /></span>
<span className='formula_number'>27</span>
<span className='formula_number'>(27)</span>
</div>
</MathJax.Provider>
......@@ -494,29 +469,24 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[FeaR\\mathrm{-}PA]}{\\mathrm{d}t} = \\frac{k_{cat\\_FeaR}[FeaR][PA_{cyto}]}{K_{M\\_FeaR}} - k_{cat\\_FeaR}[FeaR\\mathrm{-}PA]`} /></span>
<span className='formula_number'>28</span>
</div>
<span className='formula_number'>(28)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[FeaR]}{\\mathrm{d}t} = - \\frac{k_{cat\\_FeaR}[FeaR][PA_{cyto}]}{K_{M\\_FeaR}} + k_{cat\\_FeaR}[FeaR\\mathrm{-}PA]`} /> </span>
<span className='formula_number'>29</span>
</div>
<span className='formula_number'>(29)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[PA_{cyto}]}{\\mathrm{d}t} = - \\frac{k_{cat\\_FeaR}[FeaR][PA_{cyto}]}{K_{M\\_FeaR}}`} /> </span>
<span className='formula_number'>30</span>
</div>
<span className='formula_number'>(30)</span> </div>
<div className='indent formula_content' id='long_formula'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[PAA_{cyto}]}{\\mathrm{d}t} = k_{cat\\_FeaR}[FeaR\\mathrm{-}PA] + \\frac{k_{diff\\_PAA}}{V_{cyto}}([PAA_{gut}]-[PAA_{cyto}])`} /> </span>
<span className='formula_number'>31</span>
</div>
<span className='formula_number'>(31)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[PAA_{gut}]}{\\mathrm{d}t} = \\frac{k_{diff\\_PAA}}{V_{gut}}([PAA_{cyto}]-[PAA_{gut}])`} /> </span>
<span className='formula_number'>32</span>
</div>
<span className='formula_number'>(32)</span> </div>
</MathJax.Provider>
......@@ -530,42 +500,35 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`P_{TynA\\_GS}+FeaR-PA\\overset{}{\\underset{}{\\rightleftharpoons}}P_{TynA\\_GS\\_active}`} /></span>
<span className='formula_number'>33</span>
</div>
<span className='formula_number'>(33)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`P_{TynA\\_TPH1}+FeaR-PA\\overset{}{\\underset{}{\\rightleftharpoons}}P_{TynA\\_TPH1\\_active}`} /> </span>
<span className='formula_number'>34</span>
</div>
<span className='formula_number'>(34)</span> </div>
</MathJax.Provider>
<p>The corresponding set of ODEs is</p>
<MathJax.Provider>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[P_{TynA\\_GS\\_active}]}{\\mathrm{d}t} = k_{f\\_PtynA}[P_{TynA\\_GS}][FeaR\\mathrm{-}PA] - k_{r\\_PtynA}[P_{TynA\\_GS\\_active}]`} /></span>
<span className='formula_number'>35</span>
</div>
<span className='formula_number'>(35)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[P_{TynA\\_TPH1\\_active}]}{\\mathrm{d}t} = k_{f\\_PtynA}[P_{TynA\\_TPH1}][FeaR\\mathrm{-}PA] - k_{r\\_PtynA}[P_{TynA\\_TPH1\\_active}]`} /> </span>
<span className='formula_number'>36</span>
</div>
<span className='formula_number'>(36)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[P_{TynA\\_GS}]}{\\mathrm{d}t} = -k_{f\\_PtynA}[P_{TynA\\_GS}][FeaR\\mathrm{-}PA] + k_{r\\_PtynA}[P_{TynA\\_GS\\_active}]`} /></span>
<span className='formula_number'>37</span>
</div>
<span className='formula_number'>(37)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[P_{TynA\\_TPH1}]}{\\mathrm{d}t} = -k_{f\\_PtynA}[P_{TynA\\_TPH1}][FeaR\\mathrm{-}PA] + k_{r\\_PtynA}[P_{TynA\\_TPH1\\_active}]`} /></span>
<span className='formula_number'>38</span>
</div>
<span className='formula_number'>(38)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[FeaR\\mathrm{-}PA]}{\\mathrm{d}t} = -k_{f\\_PtynA}[P_{TynA\\_GS}][FeaR\\mathrm{-}PA] - k_{f\\_PtynA}[P_{TynA\\_TPH1}][FeaR\\mathrm{-}PA] + k_{r\\_PtynA}[P_{TynA\\_GS\\_active}] + k_{r\\_PtynA}[P_{TynA\\_TPH1\\_active}]`} /></span>
<span className='formula_number'>39</span>
</div>
<span className='formula_number'>(39)</span> </div>
</MathJax.Provider>
<p>where <MathJax.Provider>
......@@ -587,71 +550,59 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`P_{TynA\\_GS\\_active} \\rightarrow P_{TynA\\_GS\\_active} + mRNA_{GS}`} /></span>
<span className='formula_number'>40</span>
</div>
<span className='formula_number'>(40)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`P_{TynA\\_TPH1\\_active} \\rightarrow P_{TynA\\_TPH1\\_active}+mRNA_{TPH1}`} /> </span>
<span className='formula_number'>41</span>
</div>
<span className='formula_number'>(41)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`mRNA_{GS}\\rightarrow \\varnothing`} /> </span>
<span className='formula_number'>42</span>
</div>
<span className='formula_number'>(42)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`mRNA_{TPH1}\\rightarrow \\varnothing`} /> </span>
<span className='formula_number'>43</span>
</div>
<span className='formula_number'>(43)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[mRNA_{GS}]}{\\mathrm{d}t} = k_{mRNA\\_GS}[P_{TynA\\_GS\\_active}] - d_{mRNA\\_GS}[mRNA_{GS}]`} /> </span>
<span className='formula_number'>44</span>
</div>
<span className='formula_number'>(44)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[mRNA_{TPH1}]}{\\mathrm{d}t} = k_{mRNA\\_TPH1}[P_{TynA\\_TPH1\\_active}] - d_{mRNA\\_TPH1}[mRNA_{TPH1}]`} /> </span>
<span className='formula_number'>45</span>
</div>
<span className='formula_number'>(45)</span> </div>
</MathJax.Provider>
<p>Next is the process of translation and degradation of the target protein.</p>
<MathJax.Provider>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`mRNA_{GS}\\rightarrow mRNA_{GS}+GS`} /></span>
<span className='formula_number'>46</span>
<span className='formula_number'>(46)</span>
</div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`mRNA_{TPH1}\\rightarrow mRNA_{TPH1}+TPH1`} /> </span>
<span className='formula_number'>48</span>
</div>
<span className='formula_number'>(48)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`GS\\rightarrow \\varnothing`} /> </span>
<span className='formula_number'>49</span>
</div>
<span className='formula_number'>(49)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`TPH1\\rightarrow \\varnothing`} /> </span>
<span className='formula_number'>50</span>
</div>
<span className='formula_number'>(50)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[GS]}{\\mathrm{d}t} = p_{GS}[mRNA_{GS}] - d_{GS}[GS]`} /> </span>
<span className='formula_number'>51</span>
</div>
<span className='formula_number'>(51)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[TPH1]}{\\mathrm{d}t} = p_{TPH1}[mRNA_{TPH1}] - d_{TPH1}[TPH1]`} /> </span>
<span className='formula_number'>52</span>
</div>
<span className='formula_number'>(52)</span> </div>
</MathJax.Provider>
......@@ -661,23 +612,19 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`Glu_{gut}\\overset{}{\\underset{}{\\rightleftharpoons}}Glu_{cyto}`} /></span>
<span className='formula_number'>53</span>
</div>
<span className='formula_number'>(53)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`NH_{3_{Peri}}\\overset{}{\\underset{}{\\rightleftharpoons}}NH_{3_{cyto}}`} /> </span>
<span className='formula_number'>54</span>
</div>
<span className='formula_number'>(54)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`Glu_{cyto}+ NH_{3\\_cyto}\\xrightarrow[] Gln_{cyto}`} /> </span>
<span className='formula_number'>55</span>
</div>
<span className='formula_number'>(55)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`Gln_{cyto}\\overset{}{\\underset{}{\\rightleftharpoons}} Gln_{gut}`} /> </span>
<span className='formula_number'>56</span>
</div>
<span className='formula_number'>(56)</span> </div>
</MathJax.Provider>
<p>For an enzyme-catalyzed reaction involving two substrates that form a single product, the Michaelis-Menten equation can be extended to account for the involvement of both substrates. The general reaction can be written as</p>
......@@ -685,16 +632,14 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`E+A+B\\overset{k_{f1}}{\\underset{k_{r1}}{\\rightleftharpoons}}EAB \\xrightarrow{k_{cat}}E+P]`} /></span>
<span className='formula_number'>57</span>
</div>
<span className='formula_number'>(57)</span> </div>
</MathJax.Provider>
<p>The Michaelis-Menten equation is</p>
<MathJax.Provider>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`v_0 = \\frac{V_{max} [A] [B]}{K_{M\\_A}[B] + K_{M\\_B}[A] + [A][B]}`} /></span>
<span className='formula_number'>58</span>
</div>
<span className='formula_number'>(58)</span> </div>
</MathJax.Provider>
<p>where <MathJax.Provider>
<span>
......@@ -727,28 +672,23 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[Glu_{gut}]}{\\mathrm{d}t} = \\frac{k_{diff\\_Glu}}{V_{gut}}([Glu_{cyto}]-[Glu_{gut}])`} /></span>
<span className='formula_number'>59</span>
</div>
<span className='formula_number'>(59)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[Glu_{cyto}]}{\\mathrm{d}t} = \\frac{k_{diff\\_Glu}}{V_{cyto}}([Glu_{gut}]-[Glu_{cyto}]) - \\frac{k_{cat\\_GS}[GS][Glu_{cyto}][NH_{3\\_cyto}]}{(K_{M\\_GS\\_Glu}+[Glu_{cyto}])(K_{M\\_GS\\_NH3}+[NH_{3\\_cyto}])}`} /></span>
<span className='formula_number'>60</span>
</div>
<span className='formula_number'>(60)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[NH_{3\\_cyto}]}{\\mathrm{d}t} = \\frac{k_{diff\\_NH3}}{V_{cyto}}([NH_{3\\_peri}]-[NH_{3\\_cyto}]) - \\frac{k_{cat\\_GS}[GS][Glu_{cyto}][NH_{3\\_cyto}]}{(K_{M\\_GS\\_Glu}+[Glu_{cyto}])(K_{M\\_GS\\_NH3}+[NH_{3\\_cyto}])}`} /> </span>
<span className='formula_number'>61</span>
</div>
<span className='formula_number'>(61)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[Gln_{cyto}]}{\\mathrm{d}t} = \\frac{k_{cat\\_GS}[GS][Glu_{cyto}][NH_{3\\_cyto}]}{(K_{M\\_GS\\_Glu}+[Glu_{cyto}])(K_{M\\_GS\\_NH3}+[NH_{3\\_cyto}])} + \\frac{k_{diff\\_Gln}}{V_{cyto}}([Gln_{gut}]-[Gln_{cyto}])`} /></span>
<span className='formula_number'>62</span>
</div>
<span className='formula_number'>(62)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[Gln_{gut}]}{\\mathrm{d}t} = \\frac{k_{diff\\_Gln}}{V_{gut}}([Gln_{cyto}]-[Gln_{gut}])`} /></span>
<span className='formula_number'>63</span>
</div>
<span className='formula_number'>(63)</span> </div>
</MathJax.Provider>
<p>TPH1 converts tryptophan that enters the cytoplasm into 5-hydroxytryptophan, which is then transported from the cytoplasm into the gut. The corresponding reaction equations and ODEs are as follows</p>
......@@ -757,38 +697,31 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`Trp_{gut}\\overset{}{\\underset{}{\\rightleftharpoons}}Trp_{cyto}`} /></span>
<span className='formula_number'>64</span>
</div>
<span className='formula_number'>(64)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`Trp_{cyto}\\xrightarrow{TPH1}5-HTP_{cyto}`} /></span>
<span className='formula_number'>65</span>
</div>
<span className='formula_number'>(65)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`5-HTP_{cyto}\\overset{}{\\underset{}{\\rightleftharpoons}}5-HTP_{gut}`} /></span>
<span className='formula_number'>66</span>
</div>
<span className='formula_number'>(66)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[Trp_{gut}]}{\\mathrm{d}t} = \\frac{k_{diff\\_Trp}}{V_{gut}}([Trp_{cyto}]-[Trp_{gut}])`} /> </span>
<span className='formula_number'>67</span>
</div>
<span className='formula_number'>(67)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[Trp_{cyto}]}{\\mathrm{d}t} = \\frac{k_{diff\\_Trp}}{V_{cyto}}([Trp_{gut}]-[Trp_{cyto}]) - \\frac{k_{cat\\_TPH1}[TPH1][Trp_{cyto}]}{K_{M\\_TPH1}+[Trp_{cyto}]}`} /></span>
<span className='formula_number'>68</span>
</div>
<span className='formula_number'>(68)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[5\\mathrm{-}HTP_{cyto}]}{\\mathrm{d}t} = \\frac{k_{cat\\_TPH1}[TPH1][Trp_{cyto}]}{K_{M\\_TPH1}+[Trp_{cyto}]} - \\frac{k_{diff\\_5-HTP}}{V_{cyto}}([5\\mathrm{-}HTP_{gut}]-[5\\mathrm{-}HTP_{cyto}])`} /></span>
<span className='formula_number'>69</span>
</div>
<span className='formula_number'>(69)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[5\\mathrm{-}HTP_{gut}]}{\\mathrm{d}t} = \\frac{k_{diff\\_5-HTP}}{V_{gut}}([5\\mathrm{-}HTP_{cyto}]-[5\\mathrm{-}HTP_{gut}])`} /></span>
<span className='formula_number'>70</span>
</div>
<span className='formula_number'>(70)</span> </div>
</MathJax.Provider>
<h3>1.4 Full ODE Model</h3>
......@@ -797,138 +730,112 @@ export function Model() {
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[PEA_{gut}]}{\\mathrm{d}t} = \\frac{k_{diff\\_PEA}}{V_{gut}}([PEA_{peri}]-[PEA_{gut}])`} /></span>
<span className='formula_number'>71</span>
</div>
<span className='formula_number'>(71)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[PEA_{peri}]}{\\mathrm{d}t} = \\frac{k_{diff\\_PEA}}{V_{peri}}([PEA_{gut}]-[PEA_{peri}]) -\\frac{k_{cat\\_TynA}[TynA][PEA_{peri}]}{K_{M\\_TynA}+[PEA_{peri}]}`} /> </span>
<span className='formula_number'>72</span>
</div>
<span className='formula_number'>(72)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[PA_{peri}]}{\\mathrm{d}t} = \\frac{k_{cat\\_TynA}[TynA][PEA_{peri}]}{K_{M\\_TynA}+[PEA_{peri}]} + \\frac{k_{diff\\_PA}}{V_{peri}}([PA_{cyto}]-[PA_{peri}])`} /> </span>
<span className='formula_number'>73</span>
</div>
<span className='formula_number'>(73)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[NH_{3\\_peri}]}{\\mathrm{d}t} = \\frac{k_{cat\\_TynA}[TynA][PEA_{peri}]}{K_{M\\_TynA}+[PEA_{peri}]} + \\frac{k_{diff\\_NH3}}{V_{peri}}([NH_{3\\_cyto}]-[NH_{3\\_peri}])`} /> </span>
<span className='formula_number'>74</span>
</div>
<span className='formula_number'>(74)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[PA_{cyto}]}{\\mathrm{d}t} = \\frac{k_{diff\\_PA}}{V_{cyto}}([PA_{peri}]-[PA_{cyto}]) - \\frac{k_{cat\\_FeaR}[FeaR][PA_{cyto}]}{K_{M\\_FeaR}}`} /> </span>
<span className='formula_number'>75</span>
</div>
<span className='formula_number'>(75)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[NH_{3\\_cyto}]}{\\mathrm{d}t} = \\frac{k_{diff\\_NH3}}{V_{cyto}}([NH_{3\\_peri}]-[NH_{3\\_cyto}]) - \\frac{k_{cat\\_GS}[GS][Glu_{cyto}][NH_{3\\_cyto}]}{(K_{M\\_GS\\_Glu}+[Glu_{cyto}])(K_{M\\_GS\\_NH3}+[NH_{3\\_cyto}])}`} /></span>
<span className='formula_number'>76</span>
</div>
<span className='formula_number'>(76)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[PAA_{cyto}]}{\\mathrm{d}t} = k_{cat\\_FeaR}[FeaR\\mathrm{-}PA] + \\frac{k_{diff\\_PAA}}{V_{cyto}}([PAA_{gut}]-[PAA_{cyto}])`} /> </span>
<span className='formula_number'>77</span>
</div>
<span className='formula_number'>(77)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[PAA_{gut}]}{\\mathrm{d}t} = \\frac{k_{diff\\_PAA}}{V_{gut}}([PAA_{cyto}]-[PAA_{gut}])`} /></span>
<span className='formula_number'>78</span>
</div>
<span className='formula_number'>(78)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[P_{TynA\\_GS\\_active}]}{\\mathrm{d}t} = k_{f\\_PtynA}[P_{TynA\\_GS}][FeaR\\mathrm{-}PA] - k_{r\\_PtynA}[P_{TynA\\_GS\\_active}]`} /> </span>
<span className='formula_number'>79</span>
</div>
<span className='formula_number'>(79)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[P_{TynA\\_TPH1\\_active}]}{\\mathrm{d}t} = k_{f\\_PtynA}[P_{TynA\\_TPH1}][FeaR\\mathrm{-}PA] - k_{r\\_PtynA}[P_{TynA\\_TPH1\\_active}]`} /> </span>
<span className='formula_number'>80</span>
</div>
<span className='formula_number'>(80)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[P_{TynA\\_GS}]}{\\mathrm{d}t} = -k_{f\\_PtynA}[P_{TynA\\_GS}][FeaR\\mathrm{-}PA] + k_{r\\_PtynA}[P_{TynA\\_GS\\_active}]`} /> </span>
<span className='formula_number'>81</span>
</div>
<span className='formula_number'>(81)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[P_{TynA\\_TPH1}]}{\\mathrm{d}t} = -k_{f\\_PtynA}[P_{TynA\\_TPH1}][FeaR\\mathrm{-}PA] + k_{r\\_PtynA}[P_{TynA\\_TPH1\\_active}]`} /></span>
<span className='formula_number'>82</span>
</div>
<span className='formula_number'>(82)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[FeaR]}{\\mathrm{d}t} = - \\frac{k_{cat\\_FeaR}[FeaR][PA_{cyto}]}{K_{M\\_FeaR}} + k_{cat\\_FeaR}[FeaR\\mathrm{-}PA]`} /> </span>
<span className='formula_number'>83</span>
</div>
<span className='formula_number'>(83)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[FeaR\\mathrm{-}PA]}{\\mathrm{d}t} = \\frac{k_{cat\\_FeaR}[FeaR][PA_{cyto}]}{K_{M\\_FeaR}} - k_{cat\\_FeaR}[FeaR\\mathrm{-}PA] -k_{f\\_PtynA}[P_{TynA\\_GS}][FeaR\\mathrm{-}PA] - k_{f\\_PtynA}[P_{TynA\\_TPH1}][FeaR\\mathrm{-}PA] + k_{r\\_PtynA}[P_{TynA\\_GS\\_active}] + k_{r\\_PtynA}[P_{TynA\\_TPH1\\_active}]`} /> </span>
<span className='formula_number'>84</span>
</div>
<span className='formula_number'>(84)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[mRNA_{GS}]}{\\mathrm{d}t} = k_{mRNA\\_GS}[P_{TynA\\_GS\\_active}] - d_{mRNA\\_GS}[mRNA_{GS}]`} /></span>
<span className='formula_number'>85</span>
</div>
<span className='formula_number'>(85)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[mRNA_{TPH1}]}{\\mathrm{d}t} = k_{mRNA\\_TPH1}[P_{TynA\\_TPH1\\_active}] - d_{mRNA\\_TPH1}[mRNA_{TPH1}]`} /> </span>
<span className='formula_number'>86</span>
</div>
<span className='formula_number'>(86)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[GS]}{\\mathrm{d}t} = p_{GS}[mRNA_{GS}] - d_{GS}[GS]`} /> </span>
<span className='formula_number'>87</span>
</div>
<span className='formula_number'>(87)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[TPH1]}{\\mathrm{d}t} = p_{TPH1}[mRNA_{TPH1}] - d_{TPH1}[TPH1]`} /> </span>
<span className='formula_number'>88</span>
</div>
<span className='formula_number'>(88)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[Glu_{gut}]}{\\mathrm{d}t} = \\frac{k_{diff\\_Glu}}{V_{gut}}([Glu_{cyto}]-[Glu_{gut}])`} /> </span>
<span className='formula_number'>89</span>
</div>
<span className='formula_number'>(89)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[Glu_{cyto}]}{\\mathrm{d}t} = \\frac{k_{diff\\_Glu}}{V_{cyto}}([Glu_{gut}]-[Glu_{cyto}]) - \\frac{k_{cat\\_GS}[GS][Glu_{cyto}][NH_{3\\_cyto}]}{(K_{M\\_GS\\_Glu}+[Glu_{cyto}])(K_{M\\_GS\\_NH3}+[NH_{3\\_cyto}])}`} /> </span>
<span className='formula_number'>90</span>
</div>
<span className='formula_number'>(90)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[Gln_{cyto}]}{\\mathrm{d}t} = \\frac{k_{cat\\_GS}[GS][Glu_{cyto}][NH_{3\\_cyto}]}{(K_{M\\_GS\\_Glu}+[Glu_{cyto}])(K_{M\\_GS\\_NH3}+[NH_{3\\_cyto}])} + \\frac{k_{diff\\_Gln}}{V_{cyto}}([Gln_{gut}]-[Gln_{cyto}])`} /> </span>
<span className='formula_number'>91</span>
</div>
<span className='formula_number'>(91)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[Gln_{gut}]}{\\mathrm{d}t} = \\frac{k_{diff\\_Gln}}{V_{gut}}([Gln_{cyto}]-[Gln_{gut}])`} /></span>
<span className='formula_number'>92</span>
</div>
<span className='formula_number'>(92)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[Trp_{gut}]}{\\mathrm{d}t} = \\frac{k_{diff\\_Trp}}{V_{gut}}([Trp_{cyto}]-[Trp_{gut}])`} /></span>
<span className='formula_number'>93</span>
</div>
<span className='formula_number'>(93)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[Trp_{cyto}]}{\\mathrm{d}t} = \\frac{k_{diff\\_Trp}}{V_{cyto}}([Trp_{gut}]-[Trp_{cyto}]) - \\frac{k_{cat\\_TPH1}[TPH1][Trp_{cyto}]}{K_{M\\_TPH1}+[Trp_{cyto}]}`} /></span>
<span className='formula_number'>94</span>
</div>
<span className='formula_number'>(94)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[5\\mathrm{-}HTP_{cyto}]}{\\mathrm{d}t} = \\frac{k_{cat\\_TPH1}[TPH1][Trp_{cyto}]}{K_{M\\_TPH1}+[Trp_{cyto}]} - \\frac{k_{diff\\_5-HTP}}{V_{cyto}}([5\\mathrm{-}HTP_{gut}]-[5\\mathrm{-}HTP_{cyto}])`} /> </span>
<span className='formula_number'>95</span>
</div>
<span className='formula_number'>(95)</span> </div>
<div className='indent formula_content'>
<span className='formula_line'>
<MathJax.Node formula={`\\frac{\\mathrm{d}[5\\mathrm{-}HTP_{gut}]}{\\mathrm{d}t} = \\frac{k_{diff\\_5-HTP}}{V_{gut}}([5\\mathrm{-}HTP_{cyto}]-[5\\mathrm{-}HTP_{gut}])`} /> </span>
<span className='formula_number'>96</span>
</div>
<span className='formula_number'>(96)</span> </div>
</MathJax.Provider>
<h3>Initial Conditions</h3>
<p>Except for the variables mentioned below, the initial values of all other variables are set to 0.</p>
<p>Placeholders</p>
<p>Placeholders</p>
</Element>
<Element name="section2" className="element" id='section2'>
<h2>PART2 Metabolic Engineering Strategy to Reduce Ammonia Production</h2>
......@@ -948,7 +855,7 @@ export function Model() {
<MathJax.Provider>
<div className='indent formula_content' >
<span className='formula_line'><MathJax.Node formula={`\\begin{align*}&\\max \\quad \\mathbf{c}^T \\mathbf{v}\\\\&\\begin{array}{r@{\\quad}l@{}l@{\\quad}l}\\text{s.t.} \\quad & \\mathbf{S} \\mathbf{v} = \\mathbf{0}\\\\&\\mathbf{v}_{\\text{min}} \\leq \\mathbf{v} \\leq \\mathbf{v}_{\\text{max}}\\end{array} \\end{align*}`} /> </span>
<span className='formula_number'>1</span>
<span className='formula_number'>(1)</span>
</div>
</MathJax.Provider>
<p>Where:</p>
......@@ -1081,8 +988,15 @@ export function Model() {
<p>In summary, our metabolic engineering analysis provided multiple knockout schemes, including single and multi-gene knockouts. Through gene knockout, ammonia production can be reduced to approximately <b>18% </b>of the wild-type levels, while the growth rate of the strain can be maintained at about <b>80%</b> of the wild-type. This finding offers significant directions for genetic modifications in the development of engineered strains intended for in vivo therapy.</p>
</Element>
<Element name="section3" className="element " id='section3'>
<img src='https://static.igem.wiki/teams/5378/model/model3.webp' className='responsive-img'/>
<p><figcaption className='caption' >Placeholders</figcaption></p>
<h2 className="center-text mt-5">part3 Placeholders</h2>
<div>
<img src='https://static.igem.wiki/teams/5378/model/model-flow-pic.png' className='responsive-img' style={{ maxWidth: '60%', margin: '0 auto', display: 'block', paddingRight: '20%' }} />
<p><figcaption className='caption' >Protein-Ligand Complex - Molecular Dynamics Simulation with GROMACS</figcaption></p>
</div>
<img src='https://static.igem.wiki/teams/5378/model/model3.webp' className='responsive-img' />
<p><figcaption className='caption' >Placeholders</figcaption></p>
</Element>
</div>
......
src/contents/parts.tsx
+ 17
− 15
View file @ dcd89f5d
......@@ -13,9 +13,7 @@ const SideNavbar: React.FC<SideNavbarProps> = ({ activeLink }) => {
<Nav className="flex-column">
<Nav.Link as={Link} to="section1" smooth={true} duration={500} className={activeLink === 'section1' ? 'active' : 'notActive'}>Basice Parts</Nav.Link>
<Nav.Link as={Link} to="section2" smooth={true} duration={500} className={activeLink === 'section2' ? 'active' : 'notActive'}>Composite Parts</Nav.Link>
<Nav.Link as={Link} to="section3" smooth={true} duration={500} className={activeLink === 'section3' ? 'active' : 'notActive'}>Section 3</Nav.Link>
<Nav.Link as={Link} to="section4" smooth={true} duration={500} className={activeLink === 'section4' ? 'active' : 'notActive'}>Section 4</Nav.Link>
<Nav.Link as={Link} to="section5" smooth={true} duration={500} className={activeLink === 'section5' ? 'active' : 'notActive'}>Section 5</Nav.Link>
<Nav.Link as={Link} to="section3" smooth={true} duration={500} className={activeLink === 'section3' ? 'active' : 'notActive'}>Contribution</Nav.Link>
</Nav>
</div>
);
......@@ -31,20 +29,24 @@ type TableRowData = {
};
const basicParts: TableRowData[] = [
{ id: 'BBa_K5378000', type: 'Coding', description: 'GS',class:"table-element-yellow",link:'' },
{ id: 'BBa_K5378001', type: 'Coding', description: 'TPH1',class:"table-element-orange",link:''},
{ id: 'BBa_K5378006', type: 'Coding', description: 'tynA-G494S',class:"table-element-yellow",link:''},
{ id: 'BBa_K5378007', type: 'Coding', description: 'feaR-A81L',class:"table-element-orange",link:''},
{ id: 'BBa_K5378009', type: 'Promoter', description: 'PtynA',class:"table-element-yellow",link:''},
{ id: 'BBa_K5378016', type: 'RBS', description: 'RBS',class:"table-element-orange",link:''},
{ id: 'BBa_K5378007', type: 'Coding', description: 'GFP',class:"table-element-yellow table-bottom-line",link:''},
{ id: 'BBa_K5378000', type: 'Coding', description: 'GS',class:"table-element-yellow",link:'https://parts.igem.org/Part:BBa_K5378000' },
{ id: 'BBa_K5378001', type: 'Coding', description: 'TPH1',class:"table-element-orange",link:'https://parts.igem.org/Part:BBa_K5378001'},
{ id: 'BBa_K5378006', type: 'Coding', description: 'tynA-G494S',class:"table-element-yellow",link:'https://parts.igem.org/Part:BBa_K5378006'},
{ id: 'BBa_K5378007', type: 'Coding', description: 'feaR-A81L',class:"table-element-orange",link:'https://parts.igem.org/Part:BBa_K5378007'},
{ id: 'BBa_K5378009', type: 'Promoter', description: 'PtynA',class:"table-element-yellow",link:'https://parts.igem.org/Part:BBa_K5378009'},
{ id: 'BBa_K5378011', type: 'Coding', description: 'CsgA',class:"table-element-orange",link:'https://parts.igem.org/Part:BBa_K5378011'},
{ id: 'BBa_K5378012', type: 'Coding', description: 'TFF3',class:"table-element-yellow",link:'https://parts.igem.org/Part:BBa_K5378012'},
{ id: 'BBa_K5378016', type: 'RBS', description: 'RBS',class:"table-element-orange",link:'https://parts.igem.org/Part:BBa_K5378016'},
{ id: 'BBa_K5378018', type: 'Coding', description: 'GFP',class:"table-element-yellow",link:'https://parts.igem.org/Part:BBa_K5378018' },
{ id: 'BBa_K5378020', type: 'Coding', description: '6xHis',class:"table-element-orange table-bottom-line",link:'https://parts.igem.org/partsdb/edit_seq.cgi?part=BBa_K5378020'},
];
const compositeParts: TableRowData[] = [
{ id: 'BBa_K5378002', type: 'Composite', description: 'PtynA-RBS-TPH1',class:"table-element-yellow",link:'' },
{ id: 'BBa_K5378003', type: 'Composite', description: 'PtynA-RBS-GS',class:"table-element-orange",link:''},
{ id: 'BBa_K5378004', type: 'Composite', description: 'feaR-A81L-G494S-PtynA-GS',class:"table-element-yellow",link:''},
{ id: 'BBa_K5378005', type: 'Composite', description: 'feaR-A81L-G494S-PtynA-TPH1',class:"table-element-orange",link:''},
{ id: 'BBa_K5378010', type: 'Composite', description: 'PtynA-RBS-GFP',class:"table-element-yellow table-bottom-line",link:''},
{ id: 'BBa_K5378002', type: 'Composite', description: 'PtynA-RBS-TPH1',class:"table-element-yellow",link:'https://parts.igem.org/Part:BBa_K5378002' },
{ id: 'BBa_K5378003', type: 'Composite', description: 'PtynA-RBS-GS',class:"table-element-orange",link:'https://parts.igem.org/Part:BBa_K5378003'},
{ id: 'BBa_K5378004', type: 'Composite', description: 'feaR-A81L-G494S-PtynA-GS',class:"table-element-yellow",link:'https://parts.igem.org/Part:BBa_K5378004'},
{ id: 'BBa_K5378005', type: 'Composite', description: 'feaR-A81L-G494S-PtynA-TPH1',class:"table-element-orange",link:'https://parts.igem.org/Part:BBa_K5378005'},
{ id: 'BBa_K5378019', type: 'Composite', description: 'PtynA-RBS-GFP',class:"table-element-yellow",link:'https://parts.igem.org/Part:BBa_K5378019'},
{ id: 'BBa_K5378021', type: 'Composite', description: 'CsgA-6xHis-TFF3',class:"table-element-orange table-bottom-line",link:'https://parts.igem.org/Part:BBa_K5378021'},
];
export function parts() {
......
src/contents/safety.tsx
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View file @ dcd89f5d
......@@ -94,6 +94,7 @@ The next page details the security measures and considerations our team has take
<p className="indent">Additionally, we recognize that abdominal infections are a significant cause of recurrent hepatic encephalopathy and can lead to death. In response, we aim to develop an engineered bacterium capable of resisting inflammation and repairing the intestinal barrier. </p>
<p className="indent">Insights from discussions with the Peking University Medical School team have inspired our approach to utilizing curli fibers.And we referred to a study published in Nature Communications And the PATCH system was used for plasmid design. </p>
<p className="indent">In the end, the safety module we designed can effectively prevent and treat abdominal infection in patients with liver disease, solve intestinal flora disorders, support intestinal barrier function repair and alleviate complications of hepatic encephalopathy.</p>
<p className="indent">For details, you can see our safety module design section.</p>
<div className='image-container'>
<img
src="https://static.igem.wiki/teams/5378/safety/2.webp"
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