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Commit 9e892b32 authored by Aishik Nath's avatar Aishik Nath
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......@@ -32,15 +32,18 @@ def listblogs():
bloglist = {}
for filename in filenames:
with open(f'./wiki/blogs/{filename}', 'r') as file:
bloglist[filename]= markdown2.markdown(file.read(), extras=[
try:
bloglist[filename]= markdown2.markdown(file.read(), extras=[
"metadata",
]).metadata
except:
bloglist[filename]= "No Metadata"
return bloglist
@app.route('/blogs')
def blogs():
return render_template(str(Path('pages')) + '/' + 'bloglist.html', bloglist=listblogs())
return render_template(str(Path('pages')) + '/' + 'blogs.html', bloglist=listblogs())
def readblog(blog):
......@@ -56,7 +59,8 @@ def readblog(blog):
"target-blank-links",
"numbering",
"tag-friendly",
"cuddled-lists",])
"cuddled-lists",
"latex",])
except FileNotFoundError:
return 'Blog Not Found'
......
File suppressed by a .gitattributes entry or the file's encoding is unsupported.
......@@ -2,7 +2,7 @@
title: Cell
author: Soham Paul
title: 7 September 2024
date: 7 September 2024
---
#### Introduction:
......
......@@ -11,17 +11,17 @@ Since DNA is a double stranded helix, the process is initiated by the enzyme **h
The precision of the enzymes that synthesise new DNA strands is extremely high, since errors in DNA replication can result in [mutations](#), which may be harmful for the organism. By the time the replication is complete, we have two identical DNA molecules, each containing one old strand and a newly synthesised one – thus making the process **semi-conservative.**
A quote from Watson and Cricks landmark 1953 paper suggests the motivation behind this discovery:
A quote from Watson and Crick's landmark 1953 paper suggests the motivation behind this discovery:
<p align = "center">
_"It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanisms for the genetic material._
_"It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanisms for the genetic material."_
</p>
DNA replication can also be performed artificially, outside the cell. One such way of doing this is by **[Polymerase Chain Reaction (PCR)](#)**. This is useful when you have a limited amount of DNA sample and need to analyse or use it further.
#### References:
1. Crick, F. H. S. Codon-anticodon pairing: The wobble hypothesis. Journal of Molecular Biology 19, 548555 (1966)
2. Johnson, R. E., et al. Fidelity of human DNA polymerase η. Journal of Biological Chemistry 275, 74477450 (2000)
3. Watson, J. D., & Crick, F. H. S. Molecular structure of nucleic acids. Nature 171, 737738 (1953)
1. Crick, F. H. S. Codon-anticodon pairing: The wobble hypothesis. Journal of Molecular Biology 19, 548-555 (1966)
2. Johnson, R. E., et al. Fidelity of human DNA polymerase $\eta$. Journal of Biological Chemistry 275, 7447-7450 (2000)
3. Watson, J. D., & Crick, F. H. S. Molecular structure of nucleic acids. Nature 171, 737-738 (1953)
......@@ -4,7 +4,7 @@ author: Vidhi Chauhan
date: 7 September 2024
---
<p align = center>
<p align = "center">
Isothermal Titration Calorimetry is often considered the gold standard for studying interactions between molecules, primarily because of its capability to measure thermodynamic and kinetic quantities with one experiment.
......
......@@ -7,15 +7,15 @@ date: 7 September 2024
<p align = "center">
_It is not the strongest of the species that survives,_
_"It is not the strongest of the species that survives,_
_nor the most intelligent,_
_but the one that is most adaptable to change._
_but the one that is most adaptable to change."_
</p>
**Charles Darwin**
**~Charles Darwin**
It would be only fair to credit Hugo de Vries, author of the book Mutation Theory, and who suggested the concept of genes, for first proposing the concept of mutations – single step but large changes in [DNA](#) – as the mechanism for evolution . One of his famous quotes says, “The main principle of the mutation theory is that species and varieties have originated by mutation, but are, at present, not known to have originated in any other way.
It would be only fair to credit Hugo de Vries, author of the book Mutation Theory, and who suggested the concept of genes, for first proposing the concept of mutations – single step but large changes in [DNA](#) – as the mechanism for evolution . One of his famous quotes says, “The main principle of the mutation theory is that species and varieties have originated by mutation, but are, at present, not known to have originated in any other way."
So, what exactly are mutations and why should study them?
......
......@@ -4,9 +4,9 @@ title: Neurons
author: Ritik Ravichandran
date: 7 September 2024
---
<p align = center>
<p align = "center">
_It is the little grey cells, mon ami, on which one must rely._
_"It is the little grey cells, mon ami, on which one must rely."_
</p>
......@@ -22,7 +22,7 @@ The neuron consists of a **cell body** or soma which houses the [nucleus](#) of
The way the neuron fires is through a longer process from the cell body known as the **axon**. The axon is primarily responsible for the transmission of impulses away from the neuron towards the dendrites of other neurons. They can be really long, sometimes even around a meter in length! Axons sometimes have a discontinuous layer of insulating fat known as the **myelin sheath.** Gaps in the myelin sheath are called **Nodes of Ranvier.** This helps in increasing the speed of transmission of the nerve impulses, as impulses jump from node to node instead of traversing the whole distance.
Impulses travel through a neuron using electrical signals. These signals arise from a difference in charge created by ion channels, which act as invite only highways for sodium and potassium ions. This charge difference is manifested as a change in potential difference across the neuron membrane – called an **action potential,** the impulse that moves along the axon.
Impulses travel through a neuron using electrical signals. These signals arise from a difference in charge created by ion channels, which act as "invite only highways" for sodium and potassium ions. This charge difference is manifested as a change in potential difference across the neuron membrane – called an **action potential,** the impulse that moves along the axon.
This still doesn’t explain how neurons communicate with each other. Our nerves employ usage of specialised chemicals called **neurotransmitters** - the FedEx of our nervous system! These transmit the signal through a gap between neurons called a **synapse,** and cause excitation or inhibition of the next neuron. Axon terminals are the endpoints of the axon where neurotransmitters are released.
......
......@@ -5,7 +5,7 @@ author: Creetika Dahal
date: 7 September 2024
---
Plasmids are **extrachromosomal** [DNA](#) (apart from the main genetic material) present as circular structures in cells. They contain accessory [genes](#) that express specific proteins. In bacteria, these genes may code for antibiotic resistance, [enzymes](#) to utilise unique nutrient sources, virulence (the ability to cause disease), degradation of toxic compounds, and much more. Think about plasmids in cells as accessory apps on your phone: while an antivirus is not strictly required for the phone to function, it is definitely beneficial.
Plasmids are **extrachromosomal** [DNA](#) (apart from the main genetic material) present as circular structures in cells. They contain "accessory" [genes](#) that express specific proteins. In bacteria, these genes may code for antibiotic resistance, [enzymes](#) to utilise unique nutrient sources, virulence (the ability to cause disease), degradation of toxic compounds, and much more. Think about plasmids in cells as accessory apps on your phone: while an antivirus is not strictly required for the phone to function, it is definitely beneficial.
Plasmids mobilise these genes via horizontal transfer; that is, by methods other than traditional reproduction. This includes **conjugation** (cell-cell contact), **transduction** (bacteriophage, a virus which infects bacteria, carries the DNA and infects another bacterium), and **[transformation](#)** (uptake of free plasmid DNA by organisms), among others.
......
......@@ -6,7 +6,7 @@ author: Vidhi Chauhan
date: 7 September 2024
---
<p align = center>
<p align = "center">
_"Ribosomes are the key piece of the puzzle: they take the genetic blueprint and make the main actors of the biological world, the proteins"_
......
......@@ -6,7 +6,7 @@ author: Chandana Valaboju
date: 7 September 2024
---
Bacterial Transformation is a process by which a bacterium takes up foreign [DNA](#) from its surroundings through the cell membrane, and integrates it into its own DNA. The foreign DNA material may be present as partially degraded fragments of dead cells or can be artificially introduced to it. For this process to occur, the bacterium cell must be in a state called [competent state](#) (that is, the cell membrane must be permeable), which, again, can occur naturally, or be artificially induced by physical chemical methods or electrical methods. The most common way of creating competent cells is by treating them with salts of divalent cations (such as calcium and magnesium chloride) followed by rapid heating and cooling (called **heat shock**).
Bacterial Transformation is a process by which a bacterium takes up foreign [DNA](#) from its surroundings through the cell membrane, and integrates it into its own DNA. The foreign DNA material may be present as partially degraded fragments of dead cells or can be artificially introduced to it. For this process to occur, the bacterium cell must be in a state called "[competent state](#)" (that is, the cell membrane must be permeable), which, again, can occur naturally, or be artificially induced by physical chemical methods or electrical methods. The most common way of creating competent cells is by treating them with salts of divalent cations (such as calcium and magnesium chloride) followed by rapid heating and cooling (called **heat shock**).
Transformation was first discovered by Frederick Griffith in 1928, who observed that non-damaging bacteria could be ‘transformed’ into damage-inducing ones by exposing them to heat-killed strains of the latter.
......
{% extends "layout.html" %}
{% block title %}Blogs{% endblock %}
{% block lead %}Document the dates you worked on your project. This should be a detailed account of the work done each day for your project.{% endblock %}
{% block page_content %}
<link href="{{ url_for('static', filename = 'blog.css') }}" rel="stylesheet">
<div class="d-flex gap-3">
{% for blog in bloglist: %}
<div class="card-mb-4 col-3">
<div class="card-body">
<h5 class="card-title">{{ bloglist[blog]['title'] }}</h5>
<p class="card-text">{{ bloglist[blog]['author'] }}</p>
<a class="btn btn-primary" href="{{ url_for('blog', blog=blog) }}">Read</a>
</div>
</div>
{% endfor %}
</div>
{% endblock %}
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