heading:"Development of a multidisciplinary team structure",
interviewtabid:"recruiting",
cardtext:"",
quoteNachname:"Zimmermann, Instructor",
quoteVorname:"Sinan",
quote:"My first challenge was selecting the iGEM team 2024. I focused on choosing candidates with strong technical skills and the ability to work well in an interdisciplinary setting, aiming to create a diverse team with complementary strengths.",
heading:"Getting Acquainted with Cystic Fibrosis",
interviewtabid:"firstpresi",
cardtext:"",
quoteNachname:"Köhler, Teammember",
quoteVorname:"Vera",
quote:"Firstly, we discussed various project ideas, including the use of magnetic microswimmers for targeted medical applications, gene editing approaches for Cystic Fibrosis, treatments for muscular dystrophy and combating cyanobacteria with algae.",
heading:"Brainstorming and selection of ideas and concepts at team weekend in Hamburg",
interviewtabid:"ideas",
cardtext:"",
quote:"Thanks to our in-depth research phase, we were able to gather many insightful ideas. The workshop was highly productive and moved us significantly forward, allowing us to gain a clear vision of our project by the end of the day.",
heading:"Two teammembers visited the fair to talk with potential stakeholder and sponsors",
interviewtabid:"hannovermesse",
cardtext:"",
quote:"Visiting Hannover Messe was inspiring! We connected with industry leaders and discovered exciting innovations in synthetic biology that could shape our future projects.",
heading:"Identifying key experts in Cystic Fibrosis and prime editing",
interviewtabid:"experts",
cardtext:"",
quote:"Focusing on gene therapy for Cystic Fibrosis has been a meaningful journey for our team. Collaborating with experts has enriched our understanding and helped us refine our approach, especially in exploring prime editing. We're eager to turn our plans into reality and make a real impact",
heading:"Two team members connected with prospective stakeholders and sponsors.",
interviewtabid:"labsupply",
cardtext:"",
quote:"LabSupply in Münster was a fantastic opportunity to connect with passionate professionals and explore cutting-edge research tools. We're excited about the potential collaborations ahead!",
heading:"Tracking progress in expert search and idea development",
interviewtabid:"progress",
cardtext:"",
quote:"I believe our focus on a human-centric approach is crucial. It ensures that our research not only advances science but also prioritizes the needs and safety of the patients we aim to help.",
heading:"From Insights to Impact: Enhancing Awareness and Prime Editing for Cystic Fibrosis",
interviewtabid:"inisghts",
cardtext:"",
quoteNachname:"Baack, Teammember",
quoteVorname:"Anna",
quote:"I’m excited about our partnership with Mukoviszidose e.V. Deutschland to raise awareness in our community. Educating people about Cystic Fibrosis and gene therapy is essential, and I believe our scientific advancements will have a broader impact beyond just this condition.",
heading:"Educational city tour for young and old",
interviewtabid:"teuto",
type:"meta",
cardtext:"",
quoteNachname:"Sahami Moghaddam, Teammember",
quoteVorname:"Asal",
quote:"I had a great time educating the kids about gene therapy and CF in a playful way, and there were some very interesting conversations with the parents.",
heading:"Influence of research by David Liu on our design decisions ",
interviewtabid:"liu",
cardtext:"",
quote:"X",
aimofcontact:[<p>David Liu is the principal investigator responsible for the development of the prime editing systems and his laboratory is actively working on improving prime editors, also for application in CFTR mutation F508del. </p>],
insights:[<p>The talk and papers from David Liu not only introduced advances for prime editors, but also included valuable data for us to decide on which method might work best for our project. Because of this we decided to use an advanced system based on the PE6c and PE4 systems, both of which were published by the laboratory of David Liu. </p>,
heading:"Discussion on how health insurance companies manage Cystic Fibrosis patients and gene therapy treatments",
interviewtabid:"nicole",
cardtext:"",
language:"de",
quote:"Public health insurance operates under an economic efficiency principle, meaning the most cost-effective treatments are preferred. But if gene therapies become the only treatment option for certain conditions, they will likely have to be included in the coverage, which could be a challenge for the system.",
aimofcontact:"The main objective of the contact was to learn from the discussion on issues related to Cystic Fibrosis (CF), gene therapy, health insurance processes and regulatory pathways. In particular, we wanted to understand the real-world challenges and technical aspects of gene editing, especially prime editing, as well as the complexities of approval and reimbursement of gene therapies for CF patients.",
heading:"Some of our team members attended the fair in Frankfurt to network with industry leaders",
interviewtabid:"frankfurtmesse",
cardtext:"",
quote:"Achema was a great experience. I got to meet a lot of interesting people and learn about their projects. It really motivated me for my own work.",
heading:"In-Depth Visit to Specialized Physiotherapist for CF Breathing Therapy",
interviewtabid:"westhoffvisit",
cardtext:"",
language:"de",
quote:"Children are the world's best “mucus hiders”.",
aimofcontact:[<a>During the last interview with <HPLinktoOtherHPTabtab="westhoffinv"text="Katrin Westhoff"/>, she invited us to join a few physiotherapy sessions – not just as spectators but as participants. We gladly accepted and visited her in her practice. Over a few hours, we took part in four sessions with different children – not all of them CF patients. </a>],
heading:"Interview with a CF Parent and Global Advocate on Worldwide Support and Perspectives",
interviewtabid:"joshua",
cardtext:"",
language:"en",
quote:"We’ve had to sit by and watch people die, knowing that better treatment exists but is inaccessible. ",
aimofcontact:[<p>We contacted the organization <ahref="https://www.cfvww.org/">CF vests worldwide</a> with the aim to hear more diverse perspectives beyond Germany.
heading:"Enhancing Delivery Strategies and Collaboration for Prime Editing",
interviewtabid:"loop",
cardtext:"",
quoteNachname:"Wiesner, Teammember",
quoteVorname:"Lisa",
quote:"I’m thrilled with the progress we’re making in optimizing our delivery strategies. The collaboration with industry experts has opened our eyes to new possibilities, and I believe our work will significantly impact Cystic Fibrosis treatment.",
heading:"Lipid Nanoparticles in Gene Therapy: perspectives from Corden Pharma ",
interviewtabid:"corden",
cardtext:"",
language:"en",
quote:"The stability of LNPs depends on the specific lipid and RNA components used, but ensuring the overall stability of a new formulation requires rigorous empirical testing under various conditions.",
aimofcontact:[<p>The primary aim of the communication with Steffen Bira and Serra Gürcan from Corden Pharma was to explore the technical aspects and practical applications of Lipid Nanoparticles (LNPs) in advanced medical therapies, including gene therapy and inhalation treatments. The conversation focused on the possibility of using Corden Pharma’s LNP starter kits, understanding the factors affecting the stability of LNPs, and exploring options for incorporating antibodies into LNPs to target specific cells. </p>],
heading:"Innovative minds unite: iGEM's participation in 'MINT Sommer'",
interviewtabid:"minthptime",
type:"meta",
cardtext:"",
quoteNachname:"Lange, Teammember",
quoteVorname:"Kaya",
quote:"It was amazing to see how exciting the conversations were with future STEM scientists and to hear the fresh perspectives from young minds. The entire experience was both inspiring and energizing.",
heading:"Insights on the Feasibility of PACE for Prime Editing Optimization",
interviewtabid:"svenja",
cardtext:"",
language:"de",
quote:"The Safety and Security Award at iGEM underscores commitment to responsible research and innovation, ensuring that the projects prioritize the well-being of people and the environment while advancing synthetic biology.",
quoteNachname:"Vinke ,Member of the Safety and Security Committee at iGEM HQ ",
heading:"Bioethics: Best Practices for Handling Patient Data and Primary Cells",/* Guidance from Ethics Committee on Best Practices for Patient Data and Primary Cells */
interviewtabid:"berens",
cardtext:"",
language:"de",
quote:"The most important thing is a detailed letter of consent and a detailed privacy policy. This must explain to the patient as precisely as possible what happens to their cells and data, as well as the time span, which people are involved or have access to the cells and how.",
aimofcontact:"The aim of the interview was to get an answer to the question of whether we need an ethics vote for our project or not and to obtain guidelines for dealing with patient cells regarding ethical issues and data protection. ",
quote:"We were genuinely excited when Linköping University approached us for collaboration. From the very beginning, their ideas resonated with us, and our shared enthusiasm laid a strong foundation for a productive partnership. We're happy to work together, also with the other teams, and explore new possibilities.",
heading:"Discussed the processes involved in the storage, processing, and security of patient samples.",
interviewtabid:"timm",
cardtext:"",
quoteVorname:"Dr. Timm",
quoteNachname:"Weber, Scientist Project- and Quality Management Biobank",
quote:"A biobank is not just a collection of samples; it's a bridge between patient trust and scientific discovery, ensuring that valuable biological data is safeguarded while contributing to future research.",
heading:"Empowering students through synthetic biology",
interviewtabid:"schueler",
type:"meta",
cardtext:"",
quoteVorname:"Kaya",
quoteNachname:"Lange, Teamm",
quote:"It was wonderful to be part of the Student Academy and to experience how much we learned while teaching. Sharing our knowledge and seeing the students' enthusiasm was incredibly rewarding, even though we couldn't convey everything in just one session.",
heading:"Brainstorming and selection of ideas and concepts",
interviewtabid:"evidence",
cardtext:"",
quoteNachname:"Lenger, Teammember",
quoteVorname:"Malte",
quote:"Our collaborations have not only enhanced our technical capabilities but have also reinforced the importance of ethical standards in our research. Together, we are paving the way for innovative solutions in gene therapy.",
heading:"Successful participation of a team member in a 5 day GxP course",
interviewtabid:"gxpcourse",
cardtext:"",
quote:"The GXP course was extremely useful as it provided us with important knowledge that supports our entire team in complying with quality standards. This knowledge will help us to organise our processes efficiently and in accordance with regulations in the future.",
heading:"Building Connections: The Power of Collaboration and Communication",
interviewtabid:"connect",
cardtext:"",
quote:"Sharing our project updates and ideas with a diverse audience has been enlightening. The feedback we receive drives our innovation and reinforces the value of collaboration in tackling the challenges of Cystic Fibrosis.",
heading:"Hygiene concept for students with disabilities and immunocompromised employees",
interviewtabid:"johannfunke",
cardtext:"",
quote:"The implementation of the hygiene concept is proving more difficult than expected due to the bureaucracy at the university. Nevertheless, the interview gave us a good insight into this labyrinth of regulations and we got started the prozess of implementation.",
heading:"Improvement of our culture protocols and experimental outcomes, particularly in maintaining ALI cultures",
interviewtabid:"pkuehnel",
cardtext:"",
quote:"Connecting with Philipp Kühnel, an expert in nasal cell cultivation, has been invaluable. His insights and expertise in ALI techniques have significantly enhanced our understanding and approach in this crucial area of research.",
heading:"Shaping CF Therapies: Lessons Learned from Patients' Real-World Experiences",
interviewtabid:"dino",
cardtext:"",
quote:"Living with Cystic Fibrosis has been a journey of perseverance and adaptation. Despite the challenges, I've learned that taking personal responsibility for my health, staying informed, and embracing the advancements in research can lead to a much-improved quality of life.",
aimofcontact:[<p>Our goal in reaching out to Cystic Fibrosis (CF) patients was to gain a firsthand understanding of their day-to-day experiences living with the condition. We aimed to explore how recent advancements in treatments have impacted their lives and transformed their approach to managing the disease. This initiative is vital for our project, as it helps us comprehend the significance of these treatments and their broader implications. A key aspect of our outreach was partnering with the <ahref="https://www.instagram.com/accounts/login/?next=https%3A%2F%2Fwww.instagram.com%2Fmukodino%2F&is_from_rle">MukoDino</a>
who has extensive reach within the CF community. This collaboration enabled us to distribute our survey widely among those affected, as we recognized that we could not conduct as many interviews as we could reach through the survey. We also sought to gather insights on research priorities and the future direction of CF therapies. </p>],
quote:"Minimum requirement: Acute toxicity study on animals - important for calculating the starting dose for humans. In addition, pharmacological studies, genotoxic studies and immunotoxic studies. In your case also chronic toxicity studies.",
heading:"Helping and conducting experiments with yeast cells",
interviewtabid:"hakan",
cardtext:"",
quote:"Just hand me over the strain and the vector, I will try to take care of the rest.",
aimofcontact:[<p>After our interview with <HPLinktoOtherHPTabtab="saito"text="Makoto Saito"/>
we learned, that he was not able to express the SpuFz1 protein in E. coli and recommended we used yeast to produce it. We were provided with a yeast expression strain and a suitable vector to clone the coding sequence into, but we lacked the necessary know-how and the facilities to transform yeast, select for positive transformants and cultivate the yeast. </p>],
heading:"Gathering information about Chitosan coating for RNA protection",
interviewtabid:"moorlach",
cardtext:"",
language:"de",
quote:"Chitosan can stabilize RNA effectively, making it ideal for our formulations, but we must ensure the right charge ratio and particle size for successful LNP encapsulation.",
quoteNachname:"Moorlach, Expert for Chitosan coding",
heading:"Preparations for the Grand Jambooree in Paris",
interviewtabid:"jamboree",
cardtext:"",
quote:"I’m really nervous about the judging session. It feels like all our hard work is leading up to this moment, and I just hope we make a strong impression!",
