Merge branch 'main' of ssh://gitlab.igem.org/2024/bielefeld-cebitec

src/contents/Home.tsx

 import { FadeIn } from "../components/FadeIn";
 import { Breathe } from "../components/Breathe";
 import { Problems } from "../components/Problems";
-import { AirbuddyAnim } from "../components/AirbuddyAnim";
-import { PrimeGuideAnimOne, PrimeGuideAnimTwo } from "../components/PrimeGuide";
 import { useTabNavigation } from "../utils/TabNavigation";
 import { H5 } from "../components/Headings";
 import PreCyse from "../components/precyse";
@@ -38,6 +36,11 @@ export function Home() {
                 </p>
               </div>
             <div className="col header-button-row">
+            <p>
+              <div className="col">
+                    <button onClick={() => goToPageAndScroll("scrollstart", "")}> <b>SCROLL</b> to see introductory animation.</button>  
+                  </div>
+              </p>
               <p> 
                   <div className="col">
                     <button  onClick={() => goToPageAndScroll("Abstract", "/description")} > <b>CLICK</b> to go directly to our Project Description.</button> 
@@ -45,15 +48,11 @@ export function Home() {
               </p>
               <p>
                 <div className="col">
-                    <button onClick={() => goToPageAndScroll("sciency", "")}> <b>SKIP</b> to jump straight to the scienicy part of the animation.</button>   
+                    <button onClick={() => goToPageAndScroll("sciency", "")}> <b>JUMP</b> straight to the science part of the animation.</button>   
                   </div>
               </p>
               
-              <p>
-              <div className="col">
-                    <button onClick={() => goToPageAndScroll("scrollstart", "")}> <b>SCROLL</b> to see whole animation.</button>  
-                  </div>
-              </p>
+              
             </div>
               
             </div>
@@ -100,9 +99,24 @@ export function Home() {
           <FadeIn filepath="https://static.igem.wiki/teams/5247/landing-page/lp-6-2.svg" bg='https://static.igem.wiki/teams/5247/landing-page/lp-6-2.svg'></FadeIn>
           <FadeIn filepath="https://static.igem.wiki/teams/5247/landing-page/lp-7-2.svg" bg='https://static.igem.wiki/teams/5247/landing-page/lp-7-2.svg'></FadeIn>
           <FadeIn filepath="https://static.igem.wiki/teams/5247/landing-page/lp-8-2.svg" bg='https://static.igem.wiki/teams/5247/landing-page/lp-8-2.svg'></FadeIn>
+          <FadeIn filepath="https://static.igem.wiki/teams/5247/landing-page/lp-9-2.svg" bg='https://static.igem.wiki/teams/5247/landing-page/lp-9-2.svg'></FadeIn>
+          <FadeIn filepath="https://static.igem.wiki/teams/5247/landing-page/lp-10.svg" bg='https://static.igem.wiki/teams/5247/landing-page/lp-10.svg'></FadeIn>
+          <FadeIn filepath="https://static.igem.wiki/teams/5247/landing-page/lp-11-2.svg" bg='https://static.igem.wiki/teams/5247/landing-page/lp-11-2.svg'></FadeIn>
+          <FadeIn filepath="https://static.igem.wiki/teams/5247/landing-page/lp-12.webp" bg='https://static.igem.wiki/teams/5247/landing-page/lp-12.webp'></FadeIn>
+          <FadeIn filepath="https://static.igem.wiki/teams/5247/landing-page/lp-13-2.webp" bg='https://static.igem.wiki/teams/5247/landing-page/lp-13-2.webp'></FadeIn>
+          <FadeIn filepath="https://static.igem.wiki/teams/5247/landing-page/lp-14.webp" bg='https://static.igem.wiki/teams/5247/landing-page/lp-14.webp'></FadeIn>
+          <FadeIn filepath="https://static.igem.wiki/teams/5247/landing-page/lp-15.webp" bg='https://static.igem.wiki/teams/5247/landing-page/lp-15.webp'></FadeIn>
+          <FadeIn filepath="https://static.igem.wiki/teams/5247/landing-page/lp-16.webp" bg='https://static.igem.wiki/teams/5247/landing-page/lp-16.webp'></FadeIn>
+          <FadeIn filepath="https://static.igem.wiki/teams/5247/landing-page/lp-17.svg" bg='https://static.igem.wiki/teams/5247/landing-page/lp-17.svg'></FadeIn>
+          <FadeIn filepath="https://static.igem.wiki/teams/5247/landing-page/lp-18-2.svg" bg='https://static.igem.wiki/teams/5247/landing-page/lp-18-2.svg'></FadeIn>
+          <FadeIn filepath="https://static.igem.wiki/teams/5247/landing-page/lp-19-2.svg" bg='https://static.igem.wiki/teams/5247/landing-page/lp-19-2.svg'></FadeIn>
+
+
+
+
 
 
-         
+         {/* 
           <FadeIn filepath="https://static.igem.wiki/teams/5247/landing/gifs/3k-anim-transparent-bg.gif" bg='https://static.igem.wiki/teams/5247/landing/backgrounds/background-3-text.webp'></FadeIn>
           
           
@@ -117,7 +131,7 @@ export function Home() {
           <PrimeGuideAnimTwo></PrimeGuideAnimTwo>
 
           <FadeIn filepath="https://static.igem.wiki/teams/5247/landing/precyse.gif" bg=''></FadeIn>
-          <FadeIn filepath="https://static.igem.wiki/teams/5247/landing/gifs/proofofconcept.gif" bg=''></FadeIn>
+          <FadeIn filepath="https://static.igem.wiki/teams/5247/landing/gifs/proofofconcept.gif" bg=''></FadeIn> */}
           
           {/* Spacing Block */}
           <div className='col' style={{ 'height': '100vh' }}></div>

src/contents/description.tsx

@@ -24,7 +24,16 @@ export function Description() {
       <div className="row mt-4">
         <div className="col">
             <Section title="Abstract" id="Abstract">
-                <p id="obenindescription" >We are proud to introduce <PreCyse/>, our next-generation Prime Editing technology aimed at developing an innovative gene therapy for cystic fibrosis, specifically targeting the most common mutation, <b>F508del</b> of the CFTR gene. PreCyse is designed to address key limitations in current treatments, including limited size, speed, precision, and long-term effectiveness. Our approach integrates <b>PrimeGuide</b>, a highly optimized Prime Editing system, with <b>AirBuddy</b>, a novel lipid nanoparticle (LNP) delivery platform. The <b>SORT LNPs</b> used in AirBuddy are optimized for pulmonary delivery, offering precise organ targeting and structural stability throughout the inhalation process. As a Postdoc at the Broad Institute of MIT and Havard—where Prime Editing was first pioneered—observed, “<i>Everyone is looking for smaller prime editors</i>” and PrimeGuide embodies this vision by utilizing a smaller, more efficient editing complex. Unlike current treatments, which often require frequent administration and provide only temporary relief, PreCyse is developed as a monthly applied therapy with the potential for longer-lasting results, reducing the frequency of use and improving patient outcomes. By lowering costs and improving accessibility, PreCyse aims to offer a more advanced and user-friendly cure for cystic fibrosis. </p>
+                <p id="obenindescription">We are proud to present <PreCyse/>, a next-generation Prime Editing technology, as innovative gene therapy approach for cystic fibrosis 
+                specifically targeting the most common mutation <b>F508del</b> of the CFTR gene. Cystic fibrosis is a severe disorder that primarily affects the lungs 
+                and for which only short-term symptomatic treatments exist. PreCyse aims to provide long-term relief by delivering a small genetic payload with speed 
+                and precision. Our approach integrates <b>PrimeGuide</b>, a highly optimized Prime Editing system, with <b>AirBuddy</b>, a novel lipid nanoparticle 
+                (LNP) delivery platform. The <b>SORT LNPs</b> used in AirBuddy are optimized for pulmonary delivery, offering precise organ targeting and structural 
+                stability throughout the inhalation process. Small payload size is key for effective delivery and compatibility with viral vectors, which have a 
+                limited capacity. PrimeGuide embodies this vision by utilizing a smaller, more efficient editing complex. Current treatments often require daily 
+                administration whereas PreCyse is currently developed as a monthly applied therapy. In addition, Prime Editing holds the promise to offer a causal cure, 
+                when mutations are corrected in stem cells. Our approach aims to reduce medication frequency while improving patient outcomes. 
+                By lowering costs and improving accessibility, PreCyse aspires to offer an advanced and user-friendly cure for cystic fibrosis.</p>
             </Section>
             <Section title="Our Motivation" id="Our Motivation">
                     <div className="row align-items-center">

src/contents/methods.tsx

@@ -11,6 +11,7 @@ export function Methods() {
     return (
       <>
       
+
       
         <Section title="Introduction" id="Introduction">
           <p>This section highlights the key materials and methods pivotal to advancing our project with the primary goal to develop an efficient prime editing technology to correct the F508del mutation in the CFTR gene by the delivery to lung epithelial cells using optimized lipid nanoparticles (LNPs) via pulmonary administration. We utilized patch clamp electrophysiology to precisely measure ion channel activity, providing crucial insights into cellular function and the impact of genetic modifications on CFTR performance. Additionally, our cell culture models of lung epithelial cells allowed us to test both the delivery and efficacy of our gene-editing system under conditions that closely mimic the <i>in vivo</i> environment. To ensure that our LNPs were both effective and safe, we performed extensive LNP cytotoxicity and characterization experiments, evaluating their biocompatibility, stability, and efficiency in delivering the editing technology. Each of these methodologies was carefully selected to optimize the delivery process and maximize the therapeutic potential of our approach.</p>

src/data/hptimelinedata.tsx

@@ -1440,11 +1440,14 @@ export const timelinedata: Array<TimelineDatenpunkt>  = [
     interviewtabid: "maxhygiene",
     cardtext: "",
     language: "de",
-    quote: "x",
-    aimofcontact: "",
-    insights: "",
-    implementation: "",
-    summary: "",
+    quoteNachname:"Beckmann, Patient",
+    quoteVorname: "Max",
+    quote: "It’s important to keep my hygiene practices practical and effective, focusing on regular cleaning rather than excessive measures that may create more risks for invection.",
+    summary: [<p>In the feedback on the hygiene concept, the author states that the number of toilets required can be reduced as only a marginal number of people will be present at the university. He praised the first four points of the concept as very good and well thought out.
+
+      With regard to points five and six, he clarifies that no special hygiene items are required for the stay as long as the toilets are cleaned regularly and there is an additional service for the washbasins. He explains that the sources of danger can be significantly reduced by regular cleaning and the presence of toilet lids, which eliminates the need for special hygiene measures.
+      
+      He also argues that contactless facilities are not necessary as people wash or sanitise their hands after using the toilet anyway. Finally, he asks whether sources are needed for the hygiene concept and offers his help to create a revised version, which he would then like to review again before it is forwarded to Mr Johannfunke.</p>],
     months: "August"
   },
   {