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Commit 716ed140 authored by Liliana Sanfilippo's avatar Liliana Sanfilippo
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Description Sections

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src/contents/description.tsx
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......@@ -78,7 +78,8 @@ export function Description() {
<Subesction title="Symptoms" id="Cystic Fibrosis4">
<p>Text about symptoms</p>
<Collapsible id="symptoms-collapsible" title="How the symptoms affect different parts of the body" > Child </Collapsible>
<div id="CF5"><h3>Diagnosis</h3> </div>
</Subesction>
<Subesction title="Diagnosis" id="Cystic Fibrosis5">
<p>About the ways one can be diagnosed <LoremMedium/></p>
<div className="row align-items-center">
<div className="col" >
......@@ -90,7 +91,7 @@ export function Description() {
</div>
</div>
</Subesction>
<Subesction title="Treatment" id="Cystic Fibrosis5">
<Subesction title="Treatment" id="Cystic Fibrosis6">
<img src="https://static.igem.wiki/teams/5247/placeholders/placehilderperson.jpeg"/>
<Collapsible id="drugs-collapsible" title="Different types of drugs" >
<TabButtonRow data={medibuttonrowdata} opentype="meditabs" closing=""/>
......@@ -134,25 +135,14 @@ export function Description() {
About the Riboswitch
</InfoBox>
</Section>
<div className="col">
<section className="section">
<H2 id="Approach" text="Approach"></H2>
</section>
</div>
<div className="col">
<section className="section">
<H2 text="Delivery" id="Delivery"></H2>
<Section title="Delivery" id="Delivery">
<img className="img-left img-half spin" src="https://static.igem.wiki/teams/5247/scientific-figures/lnp.png" height={"200vw"}/>
<div>
<p>We chose LNPs as the delivery system of our Next-Generation Prime Editing Technology. Because of their large capacity and less immunogenic side effects compared to other delivery systems like Adeno-associated Viruses (AVV)<SupScrollLink label="6"/>. Our aim is to optimize the LNP formulation to improve delivery to lung tissue via inhalation. Because of our collaborations, we are able to test and optimize different delivery systems to improve our organ specific therapeutic approach. Therefore, our LNP design focusses on stability and targeting. Stability is achieved by a polyethylene glycol (PEG) coating that protects the LNPs from degradation by the immune system<SupScrollLink label="7"/>. Moreover, we use capsaicin in combination with chitosan to improve the uptake of our construct through their mucus-adhesive properties<SupScrollLink label="8"/>. </p>
</div>
<div className="row align-items-center">
<div className="col">
LAgertemperatur der Parts <LoremShort/>
Lagertemperatur der Parts <LoremShort/>
</div>
<div className="col">
Trocknung <LoremShort/>
......@@ -160,321 +150,306 @@ export function Description() {
</div>
<br/>
<p>We are furthermore optimising the LNPs for pulmonary therapy and investigating delivery by nebulisation as a non-invasive method compared to systemic approaches to make the therapy more convenient for patients. For specific targeting, we are focussing on marker proteins of basal cells and ionocytes that produce particularly high levels of CFTR protein and which we want to target with appropriate antibodies<SupScrollLink label="9"/>. Our workflow includes testing our next generation Prime Editing Technology delivered by our optimized LNPs in cell culture lines but also in primary nasal epithelial cells of CF patients to evaluate our optimizations and further improvements in vitro. We can also provide the outlook on the adaptation of the delivery system enabling systemic applications as well. </p>
</section>
</div>
<div className="col">
<section className="section">
<H2 text="Our vision" id="Our-vision"></H2>
</Section>
<Section title="Our Vision" id="Our Vision">
<p>We are envisioning a potential integration into a broader therapeutic framework involving customized gene editing tools for various genetic disorders, that present similar problems/difficulties to the F508del mutation, as well as other genetic diseases of different causes. This could include collaborations with pharmaceutical companies to develop new treatment modalities for genetic diseases beyond cystic fibrosis, utilizing advanced delivery systems and personalized medicine approaches. </p>
<H2 text="Editing Statistics"/>
<PieChart /> {/* Render the PieChart component */}
</section>
</div>
{/* Sources */}
<div className="col">
<section className="section">
<H2 text="References" id="References"></H2>
<ol>
{/* <!-- Citation num 1--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-1">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">Scotet, V.</span>,
<span property="schema:Name">Gutierrez, H.</span>,
<span property="schema:Name">Farrell, P. </span>
</span>
<span property="schema:name">Newborn Screening for CF across the Globe—Where Is It Worthwhile? </span>
<i property="schema:publisher" typeof="schema:Organization">Int J Neonatal Screen </i>
<b property="issueNumber" typeof="PublicationIssue">6</b>,
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2020">2020</time>).
<a className="doi" href="https://doi.org/10.3390/ijn6010018"> doi: 10.3390/ijn6010018</a>
</li>
{/* <!-- Citation num 2--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-2">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">Anzalone, A.V.</span>,
<span property="schema:Name">Randolph, P.B.</span>,
<span property="schema:Name">Davis, J.R.</span>,
<span property="schema:Name">Sousa, A.A.</span>,
<span property="schema:Name">Koblan, L.W.</span>,
<span property="schema:Name">Levy, J.M.</span>,
<span property="schema:Name">Newby, G.A.</span>,
<span property="schema:Name">Raguram, A.</span>,
<span property="schema:Name">Liu, D.R. </span>
</span>
<span property="schema:name">Search-and-replace genome editing without double-strand breaks or donor DNA. </span>
<i property="schema:publisher" typeof="schema:Organization">Nature </i>
<b property="issueNumber" typeof="PublicationIssue">574</b>,
<span property="schema:pageBegin"> 589</span>-<span property="schema:pageEnd">594 </span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2019">2019</time>).
<a className="doi" href="https://doi.org/10.1038/s41586-019-1711-4"> doi: 10.1038/s41586-019-1711-4</a>
</li>
{/* <!-- Citation num 3--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-3">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">Broad Institute of MIT and Harvard. </span>
</span>
<span property="schema:name">Researchers engineer in vivo delivery system for prime editing, partially restoring vision in mice. </span>
<i property="schema:publisher" typeof="schema:Organization">Phys.org </i>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2024">2024</time>).
</li>
{/* <!-- Citation num 4--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-4">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">Gaudelli, N.</span>,
<span property="schema:Name">Komor, A.</span>,
<span property="schema:Name">Rees, H.</span>,
<span property="schema:Name">Packer, M.</span>,
<span property="schema:Name">Badran, A.</span>,
<span property="schema:Name">Bryson, D.</span>,
<span property="schema:Name">Liu, D. </span>
</span>
<span property="schema:name">Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. </span>
<i property="schema:publisher" typeof="schema:Organization">Nature </i>
<b property="issueNumber" typeof="PublicationIssue">533</b>,
<span property="schema:pageBegin"> 420</span>-<span property="schema:pageEnd">424 </span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2016">2016</time>).
<a className="doi" href="https://doi.org/10.1038/nature17946"> doi: 10.1038/nature17946</a>
</li>
</Section>
<Section title="References" id="References">
<ol>
{/* <!-- Citation num 1--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-1">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">Scotet, V.</span>,
<span property="schema:Name">Gutierrez, H.</span>,
<span property="schema:Name">Farrell, P. </span>
</span>
<span property="schema:name">Newborn Screening for CF across the Globe—Where Is It Worthwhile? </span>
<i property="schema:publisher" typeof="schema:Organization">Int J Neonatal Screen </i>
<b property="issueNumber" typeof="PublicationIssue">6</b>,
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2020">2020</time>).
<a className="doi" href="https://doi.org/10.3390/ijn6010018"> doi: 10.3390/ijn6010018</a>
</li>
{/* <!-- Citation num 5--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-5">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">OpenEd CUNY. </span>
</span>
<span property="schema:name">RNA Stability and the Role of RNA-Binding Proteins. </span>
<i property="schema:publisher" typeof="schema:Organization">OpenEd CUNY </i>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2024">2024</time>).
</li>
{/* <!-- Citation num 2--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-2">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">Anzalone, A.V.</span>,
<span property="schema:Name">Randolph, P.B.</span>,
<span property="schema:Name">Davis, J.R.</span>,
<span property="schema:Name">Sousa, A.A.</span>,
<span property="schema:Name">Koblan, L.W.</span>,
<span property="schema:Name">Levy, J.M.</span>,
<span property="schema:Name">Newby, G.A.</span>,
<span property="schema:Name">Raguram, A.</span>,
<span property="schema:Name">Liu, D.R. </span>
</span>
<span property="schema:name">Search-and-replace genome editing without double-strand breaks or donor DNA. </span>
<i property="schema:publisher" typeof="schema:Organization">Nature </i>
<b property="issueNumber" typeof="PublicationIssue">574</b>,
<span property="schema:pageBegin"> 589</span>-<span property="schema:pageEnd">594 </span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2019">2019</time>).
<a className="doi" href="https://doi.org/10.1038/s41586-019-1711-4"> doi: 10.1038/s41586-019-1711-4</a>
</li>
{/* <!-- Citation num 6--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-6">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">Sahay, G.</span>,
<span property="schema:Name">Alakhova, D.Y.</span>,
<span property="schema:Name">Kabanov, A.V. </span>
</span>
<span property="schema:name">Endocytosis of nanomedicines. </span>
<i property="schema:publisher" typeof="schema:Organization">Journal of Controlled Release </i>
<b property="issueNumber" typeof="PublicationIssue">145</b>,
<span property="schema:pageBegin"> 182</span>-<span property="schema:pageEnd">195 </span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2010">2010</time>).
<a className="doi" href="https://doi.org/10.1016/j.jconrel.2010.01.036"> doi: 10.1016/j.jconrel.2010.01.036</a>
</li>
{/* <!-- Citation num 3--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-3">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">Broad Institute of MIT and Harvard. </span>
</span>
<span property="schema:name">Researchers engineer in vivo delivery system for prime editing, partially restoring vision in mice. </span>
<i property="schema:publisher" typeof="schema:Organization">Phys.org </i>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2024">2024</time>).
</li>
{/* <!-- Citation num 7--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-7">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">Ramachandran, S.</span>,
<span property="schema:Name">Satapathy, S.R.</span>,
<span property="schema:Name">Dutta, T. </span>
</span>
<span property="schema:name">Delivery Strategies for mRNA Vaccines. </span>
<i property="schema:publisher" typeof="schema:Organization">Pharmaceutical Medicine </i>
<b property="issueNumber" typeof="PublicationIssue">36</b>,
<span property="schema:pageBegin"> 11</span>-<span property="schema:pageEnd">20 </span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2022">2022</time>).
<a className="doi" href="https://doi.org/10.1007/s40290-021-00417-5"> doi: 10.1007/s40290-021-00417-5</a>
</li>
{/* <!-- Citation num 4--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-4">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">Gaudelli, N.</span>,
<span property="schema:Name">Komor, A.</span>,
<span property="schema:Name">Rees, H.</span>,
<span property="schema:Name">Packer, M.</span>,
<span property="schema:Name">Badran, A.</span>,
<span property="schema:Name">Bryson, D.</span>,
<span property="schema:Name">Liu, D. </span>
</span>
<span property="schema:name">Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. </span>
<i property="schema:publisher" typeof="schema:Organization">Nature </i>
<b property="issueNumber" typeof="PublicationIssue">533</b>,
<span property="schema:pageBegin"> 420</span>-<span property="schema:pageEnd">424 </span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2016">2016</time>).
<a className="doi" href="https://doi.org/10.1038/nature17946"> doi: 10.1038/nature17946</a>
</li>
{/* <!-- Citation num 8--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-8">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">Bandi, S.P.</span>,
<span property="schema:Name">Bhatnagar, S.</span>,
<span property="schema:Name">Venuganti, V.V.K. </span>
</span>
<span property="schema:name">Advanced materials for drug delivery across mucosal barriers. </span>
<i property="schema:publisher" typeof="schema:Organization">Acta Biomaterialia </i>
<b property="issueNumber" typeof="PublicationIssue">119</b>,
<span property="schema:pageBegin"> 13</span>-<span property="schema:pageEnd">29 </span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2021">2021</time>).
<a className="doi" href="https://doi.org/10.1016/j.actbio.2020.10.031"> doi: 10.1016/j.actbio.2020.10.031</a>
</li>
{/*<!-- Citation num 9--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-9">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Anzalone, A.</span>;
<span property="schema:Name"> Randolph, P.</span>;
<span property="schema:Name"> Davis, J.</span>;
<span property="schema:Name"> Sousa, A.</span>;
<span property="schema:Name"> Koblan, L.</span>;
<span property="schema:Name"> Levy, J.</span>;
<span property="schema:Name"> Chen, P.</span>;
<span property="schema:Name"> Wilson, C.</span>;
<span property="schema:Name"> Newby, G.</span>;
<span property="schema:Name"> Raguram, A.</span>;
<span property="schema:Name"> Liu, D.</span>
</span>
<span property="schema:name">&nbsp;Search-and-replace genome editing without double-strand breaks or donor DNA. </span>
<i property="schema:publisher" typeof="schema:Organization"> Nature</i>
<b property="issueNumber" typeof="PublicationIssue"> 576</b>,&nbsp;
<span property="schema:pageBegin">149–157</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2019">2019</time>).
<a className="doi" href="https://doi.org/10.1038/s41586-019-1711-4"> doi: 10.1038/s41586-019-1711-4</a>
</li>
{/* <!-- Citation num 5--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-5">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">OpenEd CUNY. </span>
</span>
<span property="schema:name">RNA Stability and the Role of RNA-Binding Proteins. </span>
<i property="schema:publisher" typeof="schema:Organization">OpenEd CUNY </i>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2024">2024</time>).
</li>
{/*<!-- Citation num 10--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-10">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Doman, J.</span>;
<span property="schema:Name"> Pandey, S.</span>;
<span property="schema:Name"> Neugebauer, M.</span>;
<span property="schema:Name"> An, M.</span>;
<span property="schema:Name"> Davis, J.</span>;
<span property="schema:Name"> Randolph, P.</span>;
<span property="schema:Name"> McElroy, A.</span>;
<span property="schema:Name"> Gao, X.</span>;
<span property="schema:Name"> Raguram, A.</span>;
<span property="schema:Name"> Richter, M.</span>;
<span property="schema:Name"> Everette, K.</span>;
<span property="schema:Name"> Banskota, S.</span>;
<span property="schema:Name"> Tian, K.</span>;
<span property="schema:Name"> Tao, Y.</span>;
<span property="schema:Name"> Tolar, J.</span>;
<span property="schema:Name"> Osborn, M.</span>;
<span property="schema:Name"> Liu, D.</span>
</span>
<span property="schema:name">&nbsp;Phage-assisted evolution and protein engineering yield compact, efficient prime editors. </span>
<i property="schema:publisher" typeof="schema:Organization"> Cell</i>
<b property="issueNumber" typeof="PublicationIssue"> 186</b>,&nbsp;
<span property="schema:pageBegin"> 3983</span>-<span property="schema:pageEnd">4002.e26</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2023">2023</time>).
<a className="doi" href="https://doi.org/10.1016/j.cell.2023.07.039"> doi: 10.1016/j.cell.2023.07.039</a>
</li>
{/* <!-- Citation num 6--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-6">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">Sahay, G.</span>,
<span property="schema:Name">Alakhova, D.Y.</span>,
<span property="schema:Name">Kabanov, A.V. </span>
</span>
<span property="schema:name">Endocytosis of nanomedicines. </span>
<i property="schema:publisher" typeof="schema:Organization">Journal of Controlled Release </i>
<b property="issueNumber" typeof="PublicationIssue">145</b>,
<span property="schema:pageBegin"> 182</span>-<span property="schema:pageEnd">195 </span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2010">2010</time>).
<a className="doi" href="https://doi.org/10.1016/j.jconrel.2010.01.036"> doi: 10.1016/j.jconrel.2010.01.036</a>
</li>
{/*<!-- Citation num 11--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-11">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Jinek, M.</span>;
<span property="schema:Name"> Chylinski, K.</span>;
<span property="schema:Name"> Fonfara, I.</span>;
<span property="schema:Name"> Hauer, M.</span>;
<span property="schema:Name"> Doudna, J.</span>;
<span property="schema:Name"> Charpentier, E.</span>
</span>
<span property="schema:name">&nbsp;A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity. </span>
<i property="schema:publisher" typeof="schema:Organization"> Science (New York, N.Y.)</i>
<b property="issueNumber" typeof="PublicationIssue"> 337</b>,&nbsp;
<span property="schema:pageBegin">816–821</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2012">2012</time>).
<a className="doi" href="https://doi.org/10.1126/science.1225829"> doi: 10.1126/science.1225829</a>
</li>
{/* <!-- Citation num 7--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-7">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">Ramachandran, S.</span>,
<span property="schema:Name">Satapathy, S.R.</span>,
<span property="schema:Name">Dutta, T. </span>
</span>
<span property="schema:name">Delivery Strategies for mRNA Vaccines. </span>
<i property="schema:publisher" typeof="schema:Organization">Pharmaceutical Medicine </i>
<b property="issueNumber" typeof="PublicationIssue">36</b>,
<span property="schema:pageBegin"> 11</span>-<span property="schema:pageEnd">20 </span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2022">2022</time>).
<a className="doi" href="https://doi.org/10.1007/s40290-021-00417-5"> doi: 10.1007/s40290-021-00417-5</a>
</li>
{/*<!-- Citation num 12--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-12">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Nelson, J.</span>;
<span property="schema:Name"> Randolph, P.</span>;
<span property="schema:Name"> Shen, S.</span>;
<span property="schema:Name"> Everette, K.</span>;
<span property="schema:Name"> Chen, P.</span>;
<span property="schema:Name"> Anzalone, A.</span>;
<span property="schema:Name"> An, M.</span>;
<span property="schema:Name"> Newby, G.</span>;
<span property="schema:Name"> Chen, J.</span>;
<span property="schema:Name"> Hsu, A.</span>;
<span property="schema:Name"> Liu, D.</span>
</span>
<span property="schema:name">&nbsp;Engineered pegRNAs improve prime editing efficiency. </span>
<i property="schema:publisher" typeof="schema:Organization"> Nature Biotechnology</i>
<b property="issueNumber" typeof="PublicationIssue"> 40</b>,&nbsp;
<span property="schema:pageBegin">402–410</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2022">2022</time>).
<a className="doi" href="https://doi.org/10.1038/s41587-021-01039-7"> doi: 10.1038/s41587-021-01039-7</a>
</li>
{/* <!-- Citation num 8--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-8">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name">Bandi, S.P.</span>,
<span property="schema:Name">Bhatnagar, S.</span>,
<span property="schema:Name">Venuganti, V.V.K. </span>
</span>
<span property="schema:name">Advanced materials for drug delivery across mucosal barriers. </span>
<i property="schema:publisher" typeof="schema:Organization">Acta Biomaterialia </i>
<b property="issueNumber" typeof="PublicationIssue">119</b>,
<span property="schema:pageBegin"> 13</span>-<span property="schema:pageEnd">29 </span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime="2021">2021</time>).
<a className="doi" href="https://doi.org/10.1016/j.actbio.2020.10.031"> doi: 10.1016/j.actbio.2020.10.031</a>
</li>
{/*<!-- Citation num 9--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-9">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Anzalone, A.</span>;
<span property="schema:Name"> Randolph, P.</span>;
<span property="schema:Name"> Davis, J.</span>;
<span property="schema:Name"> Sousa, A.</span>;
<span property="schema:Name"> Koblan, L.</span>;
<span property="schema:Name"> Levy, J.</span>;
<span property="schema:Name"> Chen, P.</span>;
<span property="schema:Name"> Wilson, C.</span>;
<span property="schema:Name"> Newby, G.</span>;
<span property="schema:Name"> Raguram, A.</span>;
<span property="schema:Name"> Liu, D.</span>
</span>
<span property="schema:name">&nbsp;Search-and-replace genome editing without double-strand breaks or donor DNA. </span>
<i property="schema:publisher" typeof="schema:Organization"> Nature</i>
<b property="issueNumber" typeof="PublicationIssue"> 576</b>,&nbsp;
<span property="schema:pageBegin">149–157</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2019">2019</time>).
<a className="doi" href="https://doi.org/10.1038/s41586-019-1711-4"> doi: 10.1038/s41586-019-1711-4</a>
</li>
{/*<!-- Citation num 13--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-13">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Sousa, A.</span>;
<span property="schema:Name"> Hemez, C.</span>;
<span property="schema:Name"> Lei, L.</span>;
<span property="schema:Name"> Traore, S.</span>;
<span property="schema:Name"> Kulhankova, K.</span>;
<span property="schema:Name"> Newby, G.</span>;
<span property="schema:Name"> Doman, J.</span>;
<span property="schema:Name"> Oye, K.</span>;
<span property="schema:Name"> Pandey, S.</span>;
<span property="schema:Name"> Karp, P.</span>;
<span property="schema:Name"> McCray, P.</span>;
<span property="schema:Name"> Liu, D.</span>
</span>
<span property="schema:name">&nbsp;Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells. </span>
<i property="schema:publisher" typeof="schema:Organization"> Nature Biomedical Engineering</i>
<b property="issueNumber" typeof="PublicationIssue"> </b>,&;
<span property="schema:pageBegin">1–15</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2024">2024</time>).
<a className="doi" href="https://doi.org/10.1038/s41551-024-01233-3"> doi: 10.1038/s41551-024-01233-3</a>
</li>
{/*<!-- Citation num 14--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-14">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Rodrigues, R.</span>
</span>
<span property="schema:name">&nbsp;Cystic fibrosis and neonatal screening. </span>
<i property="schema:publisher" typeof="schema:Organization"> Cadernos de Saúde Pública</i>
<b property="issueNumber" typeof="PublicationIssue"> 24</b>,&nbsp;
<span property="schema:pageBegin"> 475</span>-<span property="schema:pageEnd">484</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2008">2008</time>).
<a className="doi" href="https://doi.org/10.1590/S0102-311X2008001600002"> doi: 10.1590/S0102-311X2008001600002</a>
</li>
{/*<!-- Citation num 10--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-10">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Doman, J.</span>;
<span property="schema:Name"> Pandey, S.</span>;
<span property="schema:Name"> Neugebauer, M.</span>;
<span property="schema:Name"> An, M.</span>;
<span property="schema:Name"> Davis, J.</span>;
<span property="schema:Name"> Randolph, P.</span>;
<span property="schema:Name"> McElroy, A.</span>;
<span property="schema:Name"> Gao, X.</span>;
<span property="schema:Name"> Raguram, A.</span>;
<span property="schema:Name"> Richter, M.</span>;
<span property="schema:Name"> Everette, K.</span>;
<span property="schema:Name"> Banskota, S.</span>;
<span property="schema:Name"> Tian, K.</span>;
<span property="schema:Name"> Tao, Y.</span>;
<span property="schema:Name"> Tolar, J.</span>;
<span property="schema:Name"> Osborn, M.</span>;
<span property="schema:Name"> Liu, D.</span>
</span>
<span property="schema:name">&nbsp;Phage-assisted evolution and protein engineering yield compact, efficient prime editors. </span>
<i property="schema:publisher" typeof="schema:Organization"> Cell</i>
<b property="issueNumber" typeof="PublicationIssue"> 186</b>,&nbsp;
<span property="schema:pageBegin"> 3983</span>-<span property="schema:pageEnd">4002.e26</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2023">2023</time>).
<a className="doi" href="https://doi.org/10.1016/j.cell.2023.07.039"> doi: 10.1016/j.cell.2023.07.039</a>
</li>
{/*<!-- Citation num 15--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-15">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Farrell, P.</span>
</span>
<span property="schema:name">&nbsp;The Impact of the CFTR Gene Discovery on Cystic Fibrosis Diagnosis, Counseling, and Preventive Therapy. </span>
<i property="schema:publisher" typeof="schema:Organization"> Genes</i>
<b property="issueNumber" typeof="PublicationIssue"> 11(4)</b>,&nbsp;
<span property="schema:pageBegin">401</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2020">2020</time>).
<a className="doi" href="https://doi.org/10.3390/genes11040401"> doi: 10.3390/genes11040401</a>
</li>
{/*<!-- Citation num 11--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-11">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Jinek, M.</span>;
<span property="schema:Name"> Chylinski, K.</span>;
<span property="schema:Name"> Fonfara, I.</span>;
<span property="schema:Name"> Hauer, M.</span>;
<span property="schema:Name"> Doudna, J.</span>;
<span property="schema:Name"> Charpentier, E.</span>
</span>
<span property="schema:name">&nbsp;A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity. </span>
<i property="schema:publisher" typeof="schema:Organization"> Science (New York, N.Y.)</i>
<b property="issueNumber" typeof="PublicationIssue"> 337</b>,&nbsp;
<span property="schema:pageBegin">816–821</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2012">2012</time>).
<a className="doi" href="https://doi.org/10.1126/science.1225829"> doi: 10.1126/science.1225829</a>
</li>
{/*<!-- Citation num 16--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-16">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Lukacs, G.</span>
</span>
<span property="schema:name">&nbsp; CFTR: folding, misfolding and correcting the ΔF508 conformational defect. </span>
<i property="schema:publisher" typeof="schema:Organization"> Trends in molecular medicine</i>
<b property="issueNumber" typeof="PublicationIssue"> 18(2)</b>,&nbsp;
<span property="schema:pageBegin"> 81</span>-<span property="schema:pageEnd">91</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2012">2012</time>).
<a className="doi" href="https://doi.org/10.1016/j.molmed.2011.10.003"> doi: 10.1016/j.molmed.2011.10.003</a>
</li>
{/*<!-- Citation num 12--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-12">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Nelson, J.</span>;
<span property="schema:Name"> Randolph, P.</span>;
<span property="schema:Name"> Shen, S.</span>;
<span property="schema:Name"> Everette, K.</span>;
<span property="schema:Name"> Chen, P.</span>;
<span property="schema:Name"> Anzalone, A.</span>;
<span property="schema:Name"> An, M.</span>;
<span property="schema:Name"> Newby, G.</span>;
<span property="schema:Name"> Chen, J.</span>;
<span property="schema:Name"> Hsu, A.</span>;
<span property="schema:Name"> Liu, D.</span>
</span>
<span property="schema:name">&nbsp;Engineered pegRNAs improve prime editing efficiency. </span>
<i property="schema:publisher" typeof="schema:Organization"> Nature Biotechnology</i>
<b property="issueNumber" typeof="PublicationIssue"> 40</b>,&nbsp;
<span property="schema:pageBegin">402–410</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2022">2022</time>).
<a className="doi" href="https://doi.org/10.1038/s41587-021-01039-7"> doi: 10.1038/s41587-021-01039-7</a>
</li>
{/*<!-- Citation num 17--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-17">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Amico, G.</span>
</span>
<span property="schema:name">&nbsp;Unravelling the Regions of Mutant F508del-CFTR More Susceptible to the Action of Four Cystic Fibrosis Correctors. </span>
<i property="schema:publisher" typeof="schema:Organization"> International Journal of Molecular Sciences</i>
<b property="issueNumber" typeof="PublicationIssue"> 20(21)</b>,&nbsp;
<span property="schema:pageBegin">5463</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2019">2019</time>).
<a className="doi" href="https://doi.org/10.3390/ijms20215463"> doi: 10.3390/ijms20215463</a>
</li>
{/*<!-- Citation num 13--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-13">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Sousa, A.</span>;
<span property="schema:Name"> Hemez, C.</span>;
<span property="schema:Name"> Lei, L.</span>;
<span property="schema:Name"> Traore, S.</span>;
<span property="schema:Name"> Kulhankova, K.</span>;
<span property="schema:Name"> Newby, G.</span>;
<span property="schema:Name"> Doman, J.</span>;
<span property="schema:Name"> Oye, K.</span>;
<span property="schema:Name"> Pandey, S.</span>;
<span property="schema:Name"> Karp, P.</span>;
<span property="schema:Name"> McCray, P.</span>;
<span property="schema:Name"> Liu, D.</span>
</span>
<span property="schema:name">&nbsp;Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells. </span>
<i property="schema:publisher" typeof="schema:Organization"> Nature Biomedical Engineering</i>
<b property="issueNumber" typeof="PublicationIssue"> </b>,&;
<span property="schema:pageBegin">1–15</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2024">2024</time>).
<a className="doi" href="https://doi.org/10.1038/s41551-024-01233-3"> doi: 10.1038/s41551-024-01233-3</a>
</li>
{/*<!-- Citation num 14--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-14">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Rodrigues, R.</span>
</span>
<span property="schema:name">&nbsp;Cystic fibrosis and neonatal screening. </span>
<i property="schema:publisher" typeof="schema:Organization"> Cadernos de Saúde Pública</i>
<b property="issueNumber" typeof="PublicationIssue"> 24</b>,&nbsp;
<span property="schema:pageBegin"> 475</span>-<span property="schema:pageEnd">484</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2008">2008</time>).
<a className="doi" href="https://doi.org/10.1590/S0102-311X2008001600002"> doi: 10.1590/S0102-311X2008001600002</a>
</li>
{/*<!-- Citation num 15--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-15">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Farrell, P.</span>
</span>
<span property="schema:name">&nbsp;The Impact of the CFTR Gene Discovery on Cystic Fibrosis Diagnosis, Counseling, and Preventive Therapy. </span>
<i property="schema:publisher" typeof="schema:Organization"> Genes</i>
<b property="issueNumber" typeof="PublicationIssue"> 11(4)</b>,&nbsp;
<span property="schema:pageBegin">401</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2020">2020</time>).
<a className="doi" href="https://doi.org/10.3390/genes11040401"> doi: 10.3390/genes11040401</a>
</li>
{/*<!-- Citation num 16--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-16">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Lukacs, G.</span>
</span>
<span property="schema:name">&nbsp; CFTR: folding, misfolding and correcting the ΔF508 conformational defect. </span>
<i property="schema:publisher" typeof="schema:Organization"> Trends in molecular medicine</i>
<b property="issueNumber" typeof="PublicationIssue"> 18(2)</b>,&nbsp;
<span property="schema:pageBegin"> 81</span>-<span property="schema:pageEnd">91</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2012">2012</time>).
<a className="doi" href="https://doi.org/10.1016/j.molmed.2011.10.003"> doi: 10.1016/j.molmed.2011.10.003</a>
</li>
{/*<!-- Citation num 17--> */}
<li typeof="schema:ScolarlyArticle" role="doc-biblioentry" property="schema:citation" id="desc-17">
<span property="schema:author" typeof="schema:Person">
<span property="schema:Name"> Amico, G.</span>
</span>
<span property="schema:name">&nbsp;Unravelling the Regions of Mutant F508del-CFTR More Susceptible to the Action of Four Cystic Fibrosis Correctors. </span>
<i property="schema:publisher" typeof="schema:Organization"> International Journal of Molecular Sciences</i>
<b property="issueNumber" typeof="PublicationIssue"> 20(21)</b>,&nbsp;
<span property="schema:pageBegin">5463</span>
(<time property="schema:datePublished" datatype="xsd:gYear" dateTime=" 2019">2019</time>).
<a className="doi" href="https://doi.org/10.3390/ijms20215463"> doi: 10.3390/ijms20215463</a>
</li>
</ol>
</Section>
</ol>
</section>
</div>
</div>
......
src/sidebars/descS.tsx
+ 5
− 1
View file @ 716ed140
......@@ -13,5 +13,9 @@ export function DescSidebar(){
const tabs = [
{ tab: "Abstract" },
{ tab: "Cystic Fibrosis", subtabs: ["Overview", "The CFTR Protein", "ΔF508", "Symptoms", "Diagnosis", "Treatment"]},
{tab: "Our Motivation"}
{tab: "Our Motivation"},
{tab: "Approach"},
{tab: "Delivery"},
{tab: "Our Vision"},
{tab: "References"}
];
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