<pclass="text-center home-paragraph">Engineering non-model organisms, such as<i>M. aeruginosa</i>, is challenging due to the targeting of foreign DNA by restriction-modification (R-M) systems. TABI has developed a pipeline that identifies underrepresented motifs in non-model species like <i>M. aeruginosa</i>. By removing these motifs during plasmid synthesis, we can evade the restriction modification systems, improving transformation efficiency and enabling us to target large-scale HABs.
<pclass="text-center home-paragraph">Engineering non-model organisms, such as<i>M. aeruginosa</i>, is challenging due to the targeting of foreign DNA by restriction-modification (R-M) systems. TABI has developed a pipeline that identifies underrepresented motifs in non-model species like <i>M. aeruginosa</i>. By removing these motifs during plasmid synthesis, we can evade the restriction modification systems, improving transformation efficiency and enabling us to target large-scale HABs.