Professor Cui introduced to us the research undertaken by their group in the field of "computational-enzyme design." We reviewed the history of protein optimization and design,
highlighting areas such as rational design, semi-rational design, directed evolution, etc. She outlined the <strongstyle="color: #8a61ad;">various breakthroughs and ongoing challenges in the transition to the
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We listened to presentations from dozens of teams, both online and offline, as they shared their projects.
We also engaged in separate discussions with over ten teams. Through interactions with other teams, we gained
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When we were at CCiC, we had a preliminary understanding of PekingHSC's projects via poster and project sharing. Due to the geographical advantage, we visited Peking University's
main campus on July 24th and engaged in in-depth discussions with students from the School of Medicine at Peking University. We once again presented
<h1class="title"id="Header4">Responsibilities and Benefits</h1>
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In the process of our Human Practice, we had in-depth exchanges with biopharmaceutical companies such as VJTbio to understand the actual needs of the industry, and also discussed the direction of the project with researchers in the field of immunology.
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Our project hopes to help those groups who are committed to pet care and pet rescue. We hope to provide faster, AI-assisted antibody drug development auxiliary technology for cats, dogs and other pets.
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Our project hopes to help those groups who are committed to developing animal husbandry and developing animal husbandry drugs. We hope to accelerate the development of antibody drugs for various livestock and poultry such as cattle, sheep, pigs and chickens, and hope to use antibody drugs with fewer side effects and mild and long-lasting effects.
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Our project hopes to help all groups who care about animal drug experiments. We hope to use deep learning tools to accelerate the development of multi-species antibody drugs. We hope to maximize the role of existing antibody drugs and computer-assisted capabilities, and accelerate the development of antibody drugs as much as possible, and reduce inefficient animal experiments in antibody drug development.
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We have evaluated various types of risks, reflecting the responsible nature of our design. We have also fully validated the project, with a strong emphasis on the safety of training data and the reliability of output sequences. Antibody drugs generally do not pose a risk of drug-drug interactions with common small-molecule drugs. Due to their high specificity, they are less likely to have adverse effects on normal tissues, resulting in a lower risk of adverse reactions. Moreover, their lower immunogenicity reduces the risk of allergic reactions and immune-related adverse events. For example, in the case of antibiotics, which are widely used for animal treatments, their extensive use may not only kill beneficial bacteria but also lead to the development of antibiotic resistance in bacteria, making subsequent treatments more challenging. Antibody drugs, on the other hand, do not face these challenges and can also be used to treat diseases caused by other pathogens such as viral infections. Our project is also trying to reduce the immunogenicity of the output sequence to the target species as much as possible, making the drug safer.
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<h3class="title"style="color: #4d1288;">Public Survey: Animal Antibody Drug Awareness Survey</h3>
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We published questionnaires in Chinese and English and conducted extensive surveys. Of questionnaires collected 36% had some knowledge of how animals are treated and what happens to them, and 39% of the respondents had sought medical assistance for their animals.
But one does not exclude the use of antibody drugs as an alternative to antibiotic drugs for treatment, which are more harmful to both animals and the environment.
It can be seen from the survey that most people are willing to use antibody drugs to treat animals, and are even willing to pay more expensive prices for it. However, antibody drugs are still scarce. This reflects the significance of our project. In the questionnaires we received, there were no concerns about our project. Regarding possible hidden dangers, the drugs we design play a computer-assisted role for researchers, and drugs need to be fully verified before the drugs are actually approved for marketing.
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<h3class="title"style="color: #4d1288;">Team activity: Close contact with animals</h3>
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We also organized activities to create opportunities for team members to have close contact with animals. In early September we headed to a cat cafe and enjoyed a morning with the adorable cats. We also communicated with the cat cafe owner about the cats’ daily health. Cute cats inspire compassion and affection in us, and we feel even more deeply our responsibility and the benefits of our projects.
