@@ -55,11 +55,11 @@ At the beginning, Peking 2023 conducted a four-day laboratory professional train
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At the beginning of the project, Peking 2023 intended to select VNP20009 (a strain of *Salmonella*) as our chassis due to its high affinity to tumor tissues. However, it is modified by a pathogenic bacterium, which is not conducive to our experimental operation and future applications.
At the beginning of the project, Peking 2023 intended to select VNP20009 (a strain of *Salmonella*) as our chassis due to its high affinity to tumour tissues. However, it is modified by a pathogenic bacterium, which is not conducive to our experimental operation and future applications.
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Therefore, we chose *Escherichia coli* Nissle 1917 (EcN) as the main microbial chassis. EcN is considered a non-pathogenic strain of *E. coli* and is often used as a probiotic. Many microbial therapies use EcN as a chassis. Peking 2023 hopes to make EcN obtain tumor affinity close to VNP20009 through precise AND gate design.
Therefore, we chose *Escherichia coli* Nissle 1917 (EcN) as the main microbial chassis. EcN is considered a non-pathogenic strain of *E. coli* and is often used as a probiotic. Many microbial therapies use EcN as a chassis. Peking 2023 hopes to make EcN obtain tumour affinity close to VNP20009 through precise AND gate design.
