Peking iGEM 2023 has designed and characterized a large number of basic parts and composite parts, and the relevant parts have been uploaded to http://parts.igem.org.
We would like to thank everyone who has helped with this project and are willing to have friendly exchanges with anyone who is interested in this project.
The Peking iGEM 2023 team's project is a specially designed bacterial therapy for pancreatic cancer. We note that pancreatic cancer is difficult to detect early, has fewer drug options, and has a low five-year survival rate. To better understand the current status of pancreatic cancer treatment and the problems that need to be solved, we have communicated with physicians, medical journal editors, and pancreatic cancer patients.
The Peking iGEM 2023 team's project is a specially designed bacterial therapy for pancreatic cancer. We note that pancreatic cancer is difficult to detect at an early stage, has fewer drug options, and has a low five-year survival rate. To better understand the current status of pancreatic cancer treatment and the problems that need to be solved, we have communicated with physicians, medical journal editors, and pancreatic cancer patients.
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In interviews with doctors and editors, we learned that the current surgical resection of pancreatic cancer is very difficult, the treatment effect of traditional radiotherapy and chemotherapy is not good, and there are few drugs to choose from. Also, based on the characteristics of pancreatic cancer, the rapid development of targeted therapy and immunotherapy in recent years is not good enough for its treatment. The above interviews made us fully realize the difficulty in the treatment of pancreatic cancer, suggesting that a new treatment approach is needed for pancreatic cancer. Based on the current situation, Peking 2023 proposed an intelligent bacterial therapy for pancreatic cancer, which is expected to play a role in the treatment of pancreatic cancer.
In interviews with doctors and editors, we learned that the current surgical resection of pancreatic cancer is very difficult, the treatment effect of traditional radiotherapy and chemotherapy is away from ideal, and there are few drugs to choose from. Although targeted therapy and immunotherapy have made rapid progress in recent years, they still seem a bit impotent against the characteristics of pancreatic cancer, which makes the disease hard to be cured based on existing therapies. From the interviews above we have gained the knowledge that there are still barriers to conquer in the field of pancreatic cancer treatment, and a new treatment method is in urgent need. Based on the current situation, Peking 2023 proposed an intelligent bacterial therapy for pancreatic cancer, which is expected to play a role in the treatment of pancreatic cancer.
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In communication with pancreatic cancer patients, we fully understand the psychological activities of patients and their living conditions. In the interview, we learned that most patients are worried and anxious when they know they aresick, and it is difficult to regain the courage to live. However, attitude is one of the key factors in cancer treatment, and studies have shown that patients who have a positive attitude about the future do far better than those who have a negative attitude under the same treatment plan. In summary, we believe that the advancement of pancreatic cancer treatment requires the joint development of treatment programs and psychological education. We understand contemporary Chinese citizens' views on life and death through a questionnaire survey and find that the vast majority of people hold a negative attitude towards death, which may be influenced by the taboo of death in traditional Chinese culture. At the same time, the vast majority of people believe that the death education they have received in the past is not enough, and the future needs to popularize the philosophy of life and death. Based on the current situation, Peking 2023 conducted interviews with medical students and university professors and added life-and-death education to its publicity and education for high school students and other social groups. We hope that with our efforts, the importance of lifeanddeath education can be paid attention to, and the concept of life of citizens can be improved.
While communicating with pancreatic cancer patients, we came to understand the mental trials and tribulations of patients and their living conditions. In the interview, we learned that upon being diagnosed with pancreatic cancer, most patients showed signs of anxiety and depression, and it is difficult to regain the courage to live. Unfortunately, attitude is one of the key factors in cancer treatment, and studies have shown that patients who have a positive attitude about the future do far better than those who have a negative attitude under the same treatment plan. Therefore, we believe that the advancement of pancreatic cancer treatment requires the joint development of treatment programs and mental health support. We conducted a survey on contemporary Chinese citizens' views on life and death and find that the vast majority of people hold a negative attitude towards death, which may be influenced by the taboo of death in traditional Chinese culture. At the same time, the vast majority of people believe that the death education they have received in the past is subpar, and the need for future popularization of the philosophy of life and death lies desperate. Based on the current situation, Peking 2023 conducted interviews with medical students and university professors and brought up life-and-death education in its publicity and in educational events targeting high school students and other social groups. We hope that with our efforts, the importance of life-and-death education can be paid attention to, and the conception of life among citizens would advance.
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Dr.Zhou Yu specializes in pancreatic cancer surgery, which is challenging due to the location of important blood vessels. Only 20% of patients can be treated with surgery, while chemotherapy has limited effectiveness and side effects. New treatments or drugs may be needed in the future due to the complex nature of pancreatic cancer.
Dr.Zhou Yu specializes in pancreatic cancer surgery, which is challenging because important vesicles such as celiac trunk and superior mesenteric artery. Only 20% of patients can be treated with surgery, while chemotherapy has limited effectiveness and side effects. New treatments or drugs may be needed in the future due to the complex nature of pancreatic cancer.
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### **Patients**
**——Meilu‘s sharing her own exprience**
**——Mei Lu‘s sharing her own exprience**
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Miss Mei Lu (not her real name) is a pancreatic cancer patient who has been undergoing treatment since May 2022. She underwent open surgery and started chemotherapy in June. Despite the painful process and side effects, Mei Lu has shown strength and bravery in facing the challenges. She has experienced hair loss but found wearing a wig to be a natural solution. Mei Lu also tried traditional Chinese medicine and found it to alleviate pain and improve her appetite. She emphasized the importance of facing difficulties head-on and expressed gratitude for the opportunity to live. Mei Lu's story serves as an inspiration to others and highlights the need for advancements in pancreatic cancer treatment.
Miss Mei Lu (not her real name) is a pancreatic cancer patient who has been undergoing treatment since May 2022. She underwent open surgery and has started chemotherapy since June 2023. Despite the painful process and side effects, Mei Lu has shown strength and bravery in facing the challenges. She has experienced hair loss but found wearing a wig acceptable for all. Mei Lu also tried traditional Chinese medicine and discovered its effects to alleviate pain and improve her appetite. She emphasized the importance of facing difficulties with a head-on attitude and expressed gratitude towards the opportunity to live. Mei Lu's story serves as an inspiration to others and highlights the need for advancements in pancreatic cancer treatment.
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The representative was impressed by China Cancer Prevention Magazine's focus on cancer prevention and research. They discussed pancreatic cancer, which has a low survival rate. The magazine expressed interest in publishing the representative's research on bacteria-targeted tumor therapies. They also shared data on the increasing trend of pancreatic cancer deaths in China. The representative hopes to collaborate with the magazine in the future.
Our team was impressed by China Cancer Prevention Magazine's focus on cancer prevention and research. During the session with the editor of the journal, one of our members discussed about pancreatic cancer, which has a low survival rate, and our efforts to overcome it. The editor expressed interest in publishing our research on bacteria-targeted tumor therapies. We also shared data on the increasing trend of pancreatic cancer deaths in China. We hope to collaborate with the magazine in the future.
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Mr. Yang Zhao, a teacher at Peking University Health Science Center, discussed the innovation in pancreatic cancer treatment, including immunotherapy, targeted therapy, and gene therapy. He emphasized the importance of tumor research in drug development and recommended seeking guidance from experienced teachers. In drug administration and approval, he suggested collaborating with professional companies. The interview provided valuable insights for the research team's program.
Mr. Yang Zhao, a teacher at Peking University Health Science Center, discussed with us about the innovation in pancreatic cancer treatment, including immunotherapy, targeted therapy, and gene therapy. He emphasized the importance of tumor research in drug development and recommended seeking guidance from experts. In drug administration and approval, he suggested collaborating with professional companies. The interview provided valuable insights for the research team's program.
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### **Yu Chao**
**——Technological innovation and development trends in health based on synthetic biology**
**——Technological innovation and developmental trends in health-related technologies based on synthetic biology**
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Synthetic biology uses chemical reactions in living organisms to produce useful compounds. It is an improvement over traditional chemical synthesis due to its environmental benefits. In health, it has potential for personalized treatments, improved food production, and precise medical services. With innovative technologies, synthetic biology can bring breakthroughs to the health sector and benefit humanity.
Synthetic biology uses chemical reactions in living organisms to produce useful compounds. It is an advantage over traditional chemical synthesis due to its environmental benefits. In health, it has the potential to promote personalized treatments, improved food production, and precise medical services. With innovative technologies, synthetic biology can bring breakthroughs to the health sector and benefit humanity.
