Skip to content
Snippets Groups Projects

Compare revisions

Changes are shown as if the source revision was being merged into the target revision. Learn more about comparing revisions.

Source

Select target project
No results found

Target

Select target project
  • 2023/iit-madras
1 result
Show changes
Commits on Source (6)
Hide whitespace changes
Inline Side-by-side
wiki/pages/education.html
View file @ 9b457dc6
......@@ -11,11 +11,11 @@ with new communities by discussing public values and the science behind syntheti
</div>
<div class="hpText row">
<p class="col-lg-8">
Team iGEM IIT-Madras believes education is the strongest tool one can possess to combat the problems that the
Team iGEM IIT Madras believes education is the strongest tool one can possess to combat the problems that the
world is facing today. Throughout the course of our project, we conducted events targeting audiences from
university students and newly joined freshers to school students to teach them about basic synthetic biology
concepts and apply the knowledge they’ve accumulated to solve a crisis. Apart from this, we have continued the
Language Project started by Team iGEM IIT-Madras in 2018 by translating educational videos on our YouTube
Language Project started by Team iGEM IIT Madras in 2018 by translating educational videos on our YouTube
channel to break the barrier that language creates for information spread. We have also held hands-on sessions
for school students to create bio-art and teach them about bioethics to pique their interest in synthetic
biology and create the problem-solvers of tomorrow.
......@@ -94,6 +94,7 @@ with new communities by discussing public values and the science behind syntheti
the chance to have lunch amidst the greenery of the campus! The feedback we received was hugely positive. The
students got to have a fun and informative time. We plan to conduct more such visits, especially for schools in
underdeveloped regions.
<br><br>
<object data="https://static.igem.wiki/teams/4931/wiki/bioart-and-bioethics-school-session.pdf"
type="application/pdf" width="100%" height="850px">
<p>Unable to display PDF file. <a
......@@ -136,6 +137,7 @@ with new communities by discussing public values and the science behind syntheti
biology, participants received a comprehensive individual evaluation of their solutions, along with constructive
feedback to address any gaps in their reasoning or information. Needless to say, the event managed to ignite a
newfound interest in synthetic biology among many young undergraduates through an interactive game.
<br><br>
<object data="https://static.igem.wiki/teams/4931/wiki/synbio-auction.pdf" type="application/pdf" width="100%"
height="850px">
<p>Unable to display PDF file. <a
......@@ -164,14 +166,14 @@ with new communities by discussing public values and the science behind syntheti
Vice President for Biologics and Tumor Targeted Delivery, Ms. Anna Asberg, Vice President for R&D, IT, and Ms.
Hebe Midlemiss, Director, AI and Product Strategy, who spearheaded discussions during the offline event.
<br><br>
<strong>RESEARCH PITCH</strong><br>
<strong>RESEARCH PITCH</strong><br><br>
The event offered a platform for students to submit synopsis proposals on a range of pertinent topics,
including: <br>
1) Unleashing the Potential of Biologics through AI, ML, and Bioinformatics. <br>
2) Revolutionizing Drug Discovery through AI and In silico Methods. <br>
2) Revolutionizing Drug Discovery through AI and in <i>silico</i> Methods <br>
3) The Convergence of Synthetic Biology and Precision Medicine. <br>
4) In silico Approaches for Protein Engineering. <br>
<br><br>
4) In <i>silico</i> Approaches for Protein Engineering. <br>
<br>
Following a rigorous evaluation process by the AstraZeneca team, the top three submissions were chosen, and the
selected students had the privilege of presenting their research during the onground event in IIT Madras.
<br><br>
......@@ -179,14 +181,14 @@ with new communities by discussing public values and the science behind syntheti
event commenced with the students presenting their selected synopses, followed by an insightful Q&A session with
the judging panel, which included members of the AstraZeneca team.
<br><br>
<strong>PANEL DISCUSSION</strong> <br>
<strong>PANEL DISCUSSION</strong> <br> <br>
Subsequently, a panel discussion was held on the subject of unlocking the potential of biologics through AI, ML,
and Bioinformatics. This discussion was chaired by Dr. Puja Sapra and Ms. Anna Asberg, alongside Prof. Karthik
Raman and Prof. Meiyappan Lakshmanan from the Department of Biotechnology at IIT Madras, and students from the
departments of Computer Science and Biotechnology. It served as a platform for a rich exchange of insights into
the current applications of AI/ML in biology and the promising future prospects.
the current applications of AI/ML in biology and the promising future prospects. <br><br>
<strong>DEBATE</strong> - Does Science Drive Technology or is it the other way?
<br><br>
<br>
The event's highlight was an engaging debate session, moderated by Ms. Hebe Middlemiss, where participants,
including the AstraZeneca team, professors, and students, passionately debated whether science drives technology
or vice versa. Both sides presented compelling arguments, ultimately arriving at a consensus that science plays
......@@ -268,7 +270,7 @@ with new communities by discussing public values and the science behind syntheti
</div>
<div class="hpText row">
<p class="col-lg-8">
As part of an orientation program for aspiring IIT-M students, team iGEM had the opportunity to showcase the
As part of an orientation program for aspiring IITM students, team iGEM had the opportunity to showcase the
product of our yearlong efforts to a team of enthusiastic young minds, and introduce them to the world of
synthetic biology. As a team representing the cutting edge biological innovation, it was our privilege to
demonstrate to our peers and aspirants just what iGEM and more broadly, synthetic biology, entailed. Moreover,
......@@ -277,7 +279,7 @@ with new communities by discussing public values and the science behind syntheti
towards biology within an engineering framework was a hurdle all of us at iGEM IITM had to face at some point
within our campus lives. Therefore the opportunity to defend our work, and by extension display the sheer extent
and unimaginable capability of “bio”-tech enabled us to change quite a few minds on their perspective towards
biological engineering as a field. <br>
biological engineering as a field. <br><br>
<img src="https://static.igem.wiki/teams/4931/wiki/aspirants.jpeg" class="eduimgs synaut1">
<img src="https://static.igem.wiki/teams/4931/wiki/aspirants-1.jpeg" class="eduimgs synaut2">
</p>
......
wiki/pages/human-practices.html
View file @ 9b457dc6
......@@ -13,7 +13,7 @@ the world. Consider how the world affects your work and how your work affects th
</div>
<div class="hpText row">
<p class="col-lg-8">
As team iGEM IIT-Madras, we value how our project impacts the research being conducted in labs worldwide as well
As team iGEM IIT Madras, we value how our project impacts the research being conducted in labs worldwide as well
as how we can apply it to various industrial domains including food and cosmetic technology, production of
recombinant proteins for therapeutic purposes and biomanufacturing. To ensure that our project for this year’s
iGEM is relevant for scientists and industries, we took initiatives to meet them and get their feedback as
......@@ -21,7 +21,7 @@ the world. Consider how the world affects your work and how your work affects th
Salis who worked on developing the popularly used RBS Calculator. Based on his inputs, we detailed our model
further. To ensure that our project can be scaled up, we had talks with various well known companies like Biocon
and incorporated their inputs. We are optimistic that our project will greatly help researchers and
industrialists in fine tuning gene expression and getting higher product yields.
industrialists in fine-tuning gene expression and getting higher product yields.
</p>
</div>
<div class="hpHeading">
......@@ -47,7 +47,7 @@ the world. Consider how the world affects your work and how your work affects th
species, may play a significant role in translation efficiency and
including their effect in the model could lead to more accurate
predictions. Additionally, Dr. de Lorenzo proposed the utilization of
an in vivo recombineering tool to expand the size and diversity of our
an <i>in vivo</i> recombineering tool to expand the size and diversity of our
ribosome binding site (RBS) library. This would enable us to diversify
our toolkit more effectively.
<br><br>
......@@ -60,7 +60,7 @@ the world. Consider how the world affects your work and how your work affects th
<img src="https://static.igem.wiki/teams/4931/wiki/a-meeting-with-professor-victor-de-lorenzo.png"
class="eduimgs synaut3">
</p>
</div>
......@@ -70,10 +70,10 @@ the world. Consider how the world affects your work and how your work affects th
<div class="hpText row">
<p class="col-lg-8">
Our team has the broad goal to develop a library of synthetic ribosome binding site (RBS) sequences for
fine-tuning protein expression in Lactococcus lactis. The project also included the creation of an in silico tool
to predict the expression level of a gene and optimize its RBS sequence to achieve a desired expression level.
fine-tuning protein expression in <i>Lactococcus lactis</i>. The project also included the creation of an in <i>silico</i> tool
to predict the expression level of a gene and optimise its RBS sequence to achieve a desired expression level.
Additionally, we wanted to explore applications of RBS engineering in the development of a probiotic treatment for
homocystinuria and in the modulation of the molecular weight of hyaluronic acid produced by recombinant L. lactis.
homocystinuria and in the modulation of the molecular weight of hyaluronic acid produced by recombinant <i>L. lactis</i>.
<br><br>
Seeking expert guidance, we reached out to Professor Howard Salis, a prominent figure in the field of synthetic
biology, and the creator of the widely used RBS Calculator. The correspondence between our team and Prof. Salis
......@@ -148,13 +148,13 @@ the world. Consider how the world affects your work and how your work affects th
<p class="col-lg-8">
Biocon, a leading and innovative biopharmaceutical company known for its development of affordable biosimilars,
generic formulations, and complex APIs, warmly received our project presentation. During our presentation, we
introduced them to our RBS calculator and optimizer software, providing insights into their development,
introduced them to our RBS calculator and optimiser software, providing insights into their development,
parameter choices, and advantages over existing standards. <br> <br>
We discussed the development process, emphasizing the precision and reliability of our RBS calculator and
optimizer software. We also explained the key parameters and algorithms used to fine-tune gene expression,
optimiser software. We also explained the key parameters and algorithms used to fine-tune gene expression,
highlighting how our software offers improved control and predictability in bioengineering. <br> <br>
Our presentation showcased how our software surpasses current industry standards, offering a more efficient and
streamlined approach to optimizing gene expression. This is particularly crucial in biopharmaceutical research
streamlined approach to optimising gene expression. This is particularly crucial in biopharmaceutical research
and production. <br><br>
We engaged in a discussion about the potential for advancing our project and collaborating with Biocon for
real-world applications, especially due to their research in the field of recombinant proteins like
......@@ -162,7 +162,7 @@ the world. Consider how the world affects your work and how your work affects th
Biocon's representatives expressed their enthusiasm for our project and its potential impact, and they offered
to sponsor further research and development efforts to support innovation in the biopharmaceutical industry.
<br><br>
Biocon also extended an invitation to IIT Madras for an industry visit to their Headquarters in Bangalore,
Biocon also extended an invitation to IIT Madras for an industry visit to their headquarters in Bangalore,
providing us with an opportunity to witness their research action and explore potential synergies in person.
<br><br>
Distinguished individuals from Biocon, including Dr. Nagaraj, Dr. Krishna Rao Kamisetty, Dr. Naga Sirisha
......@@ -174,11 +174,11 @@ the world. Consider how the world affects your work and how your work affects th
</p>
</div>
<div class="hpHeading">
<h1>Conversing with Hushhai</h1>
<h1>Conversing with hushh.ai</h1>
</div>
<div class="hpText row">
<p class="col-lg-8">
As part of our efforts in making the tech-bio intersection accessible, iGEM IIT-M reached out to Manish Sainani,
As part of our efforts in making the tech-bio intersection accessible, iGEM IITM reached out to Manish Sainani,
ex–Director of Product Management at Google and founder of hushh.ai. In an in-person session, our team laid out
our perspective of the synthetic biology landscape, and where we hoped our in-house tools would make a
significant impact. As a founder in the tech-AI sphere, Mr. Sainani’s expert opinion on the potential
......@@ -242,9 +242,9 @@ the world. Consider how the world affects your work and how your work affects th
Advantages and disadvantages of various recombinant protein expression systems were discussed. She emphasized on
the importance of choosing the right chassis based on speed, cost, yield, post-translational modifications,
process development and scalability regulation approval. After receiving this insightful knowledge from her, we
discussed with her the scope of using Lactococcus lactis as an expression system since it is a GRAS organism and
discussed with her the scope of using <i>Lactococcus lactis</i> as an expression system since it is a GRAS organism and
has always been used in food technology. She greatly appeciated our initiatives in expanding the genetic
engineering toolkit for L. lactis.
engineering toolkit for <i>L. lactis</i>.
<br><br>
Finally the session concluded with an insightful discussion on whether synthetic meat proteins can ever truly
replace meat-derived proteins considering the social significance of meat. Even though it may not be widely
......