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Commit b685ee77 authored by Sishir Sivakumar's avatar Sishir Sivakumar
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{% extends "layout.html" %}
{% block title %}Human Practices{% endblock %}
{% block lead %}We ask every team to think deeply and creatively about whether their project is responsible and good for the world. Consider how the world affects your work and how your work affects the world.{% endblock %}
{% block lead %}We ask every team to think deeply and creatively about whether their project is responsible and good for
the world. Consider how the world affects your work and how your work affects the world.{% endblock %}
{% block page_content %}
<div class="row mt-4">
<div class="col">
<div class="bd-callout bd-callout-info">
<h4>Silver Medal Criterion #2</h4>
<p>Explain how you have determined your work is responsible and good for the world.</p>
<hr>
<p>Please see the <a href="https://competition.igem.org/judging/medals">2023 Medals Page</a> for more information.</p>
</div>
<div class="bd-callout bd-callout-info">
<h4>Best Integrated Human Practices</h4>
<p>To compete for the Best Integrated Human Practices prize, please describe your work on this page and also fill out the description on the <a href="https://competition.igem.org/deliverables/judging-form">judging form</a>.</p>
<p>How does your project affect society and how does society influence the direction of your project? How might ethical considerations and stakeholder input guide your project purpose and design and the experiments you conduct in the lab? How does this feedback enter into the process of your work all through the iGEM competition? Document a thoughtful and creative approach to exploring these questions and how your project evolved in the process to compete for this award!</p>
<hr>
<p>Please see the <a href="https://competition.igem.org/judging/awards">2023 Awards Page</a> for more information.</p>
</div>
<div class="hp">
<div class="hpTitle">
<h1>Human Practices</h1>
</div>
</div>
<div class="hpHeading">
<h1>SynBio Auction</h1>
</div>
<div class="hpText row">
<p class="col-lg-8">
We, iGEM IIT Madras, strongly believe that education is the only way
to empower self and society. In this mission of introducing synthetic
biology to middle and high school students to educate them about the
immense potential and the advancements going on currently, we
organized a half day visit for the students of Chennai Public School,
housed inside our very own Institute, to show them the various
facilities in the Department of Biotechnology.
<br /><br />
We started off the day with a short information session, where we
presented synthetic biology through very simple slides and gave them a
gist of genetic engineering. This was followed by an interactive
session in which the students got to know about various fields of
Biotechnology and exciting developments in the field like CRISPR-Cas.
<br /><br />
We then proceeded to introduce them to microbiology lab techniques
following a session on Good Lab Practices. A simple streaking
experiment was demonstrated to them by our lab members after which all
the students tried it on their own. Some students even tried their
hand at some Bio Art! The results of which were later shown to them
after 24 hours of incubation.
<br /><br />
As responsible scientists and engineers, it is important to understand
ethical practices and follow them religiously. We planned out an
informal debate to bring up various caveats in ethics, especially
concerns of gene modification and consent. Several students keenly
participated in the debate and brought up very insightful points. We
were moved by their conviction and clarity.
<br /><br />
To end the day on a high note, we distributed some goodies for them to
keep as souvenirs. The students also had the chance to have lunch
amidst the greenery of the campus! The feedback we received was
hugely positive. The students got to have a fun and informative time.
We plan to conduct more such visits, especially for schools in
underdeveloped regions.
</p>
</div>
<div class="hpHeading">
<h1>
A talk on recombinant proteins for food <br />
technology by the Good Food Institute
</h1>
</div>
<div class="hpText row">
<p class="col-lg-8">
Using synthetic biology to improve the quality of life and reaching
sustainable development goals is the spirit of iGEM. Keeping this goal
in mind, we conducted a session with Ms. Chandana Tekkatte, a stem
cell biologist from the Good Food Institute.
<br /><br />
<div class="row mt-4">
<div class="col-lg-8">
<h2>Overview</h2>
<hr>
<p>At iGEM we believe societal considerations should be upfront and integrated throughout the design and execution of synthetic biology projects. “Human Practices” refers to iGEM teams' efforts to actively consider how the world affects their work and their work affects the world. Through your Human Practices activities, your team should demonstrate how you have thought carefully and creatively about whether your project is responsible and good for the world. We invite you to explore issues relating (but not limited) to the ethics, safety, security, and sustainability of your project, and to show how this exploration feeds back into your project purpose, design, and execution.</p>
<p>Please note you can compete for the Silver Medal criterion #2 and the Best Integrated Human Practices prize with this page.</p>
<p>For more information, please see the <a href="https://responsibility.igem.org/human-practices/what-is-human-practices">Human Practices Hub</a>.
<p>On this page, your team should document all of your Human Practices work and activities. You should write about the Human Practices topics you considered in your project, document any activities you conducted to explore these topics (such as engaging with experts and stakeholders), describe why you took a particular approach (including referencing any work you built upon), and explain if and how you integrated takeaways from your Human Practices work back into your project purpose, design and/or execution.</p>
</div>
<div class="col-lg-4">
<h2>Inspirations</h2>
<hr>
<ul>
<li><a href="https://2019.igem.org/Team:Thessaly/Human_Practices">2019 Thessaly</a></li>
<li><a href="https://2019.igem.org/Team:Linkoping_Sweden/Human_Practices">2019 Linkoping Sweden</a></li>
<li><a href="https://2019.igem.org/Team:FDR-HB_Peru/Human_Practices">2019 FDR HB Peru</a></li>
<li><a href="https://2020.igem.org/Team:William_and_Mary/Human_Practices">2020 William and Mary</a></li>
<li><a href="https://2020.igem.org/Team:Rochester/Human_Practices">2020 Rochester</a></li>
<li><a href="https://2020.igem.org/Team:Leiden/Human_Practices">2020 Leiden</a></li>
<li><a href="https://2020.igem.org/Team:Baltimore_BioCrew/Human_Practices">2020 Baltimore BioCrew</a></li>
</ul>
The meat industry is associated with environmental degradation, animal
welfare concerns, and health implications, including antibiotic
resistance and increased risk of chronic diseases.Good Food Institute
India is a community for entrepreneurs, scientists, students, and
subject matter experts who are driving innovation in smart protein.
Their aim is to replace meat-derived proteins with sustainable plant
based synthetic proteins.
<br /><br />
Ms. Chandana Tekkate gave a talk on the importance of recombinant
protein technology in the area of food technology which will provide a
solution for the food crisis. She walked us through the different
methods of producing synthetic edible protein which use plant based
sources to make meat-like proteins along with types of fermentation
process which are used in the food industry, namely traditional
fermentation, biomass fermentation, and precision fermentation.The
proteins achieved through these methodologies are called smart
proteins.
<br /><br />
Advantages and disadvantages of various recombinant protein expression
systems were discussed. She emphasized on the importance of choosing
the right chassis based on speed, cost, yield, post-translational
modifications, process development and scalability regulation
approval. After receiving this insightful knowledge from her, we
discussed with her the scope of using Lactococcus lactis as an
expression system since it is a GRAS organism and has always been used
in food technology. She greatly appeciated our initiatives in
expanding the genetic engineering toolkit for L. lactis.
<br /><br />
Finally the session concluded with an insightful discussion on whether
synthetic meat proteins can ever truly replace meat-derived proteins
considering the social significance of meat. Even though it may not be
widely embraced at the moment, recombinant protein technology seems to
be the sustainable solution for an ever rising demand for food
proteins.
</p>
</div>
<div class="hpHeading">
<h1>A Session with AstraZeneca’s Senior Leaders</h1>
</div>
<div class="hpText row">
<p class="col-lg-8">
Artificial intelligence (AI) is currently transforming the landscape
of biologics and drug discovery, facilitating research acceleration,
target enhancement, and drug repurposing. At iGEM IIT Madras, we
firmly believe that discussions centered around AI in the realms of
biology and drug discovery are indispensable in harnessing its
potential and catalyzing innovative solutions within the healthcare
and biotechnology sectors.
<br /><br />
Our engagement with distinguished leaders, esteemed professors, and
fellow students in the domain of AI and machine learning convergence
with biologics and drug discovery was exemplified during a visit by a
prominent delegation from AstraZeneca to our campus. This delegation
featured dignitaries such as Dr. Puja Sapra, Senior Vice President for
Biologics and Tumor Targeted Delivery, Ms. Anna Asberg, Vice President
for R&D, IT, and Ms. Hebe Midlemiss, Director, AI and Product
Strategy, who spearheaded discussions during the offline event.
<br /><br />
<strong>RESEARCH PITCH </strong>
<br /><br />
The event offered a platform for students to submit synopsis proposals
on a range of pertinent topics, including: <br />
1) Unleashing the Potential of Biologics through AI, ML, and
Bioinformatics. <br />
2) Revolutionizing Drug Discovery through AI and In silico Methods.
<br />
3) The Convergence of Synthetic Biology and Precision Medicine. <br />
4) In silico Approaches for Protein Engineering. <br />
<br />
Following a rigorous evaluation process by the AstraZeneca team, the
top three submissions were chosen, and the selected students had the
privilege of presenting their research during the onground event in
IIT Madras.
<br /><br />
On September 18th, the AstraZeneca team arrived at IIT Madras for the
highly anticipated offline event. The event commenced with the
students presenting their selected synopses, followed by an insightful
Q&A session with the judging panel, which included members of the
AstraZeneca team.
<br /><br />
<strong>PANEL DISCUSSION </strong>
<br /><br />
Subsequently, a panel discussion was held on the subject of unlocking
the potential of biologics through AI, ML, and Bioinformatics. This
discussion was chaired by Dr. Puja Sapra and Ms. Anna Asberg,
alongside Prof. Karthik Raman and Prof. Meiyappan Lakshmanan from the
Department of Biotechnology at IIT Madras, and students from the
departments of Computer Science and Biotechnology. It served as a
platform for a rich exchange of insights into the current applications
of AI/ML in biology and the promising future prospects.
<br /><br />
<strong>DEBATE - Does Science Drive Technology or is it the other
way?</strong>
<br /><br />
The event's highlight was an engaging debate session, moderated by Ms.
Hebe Middlemiss, where participants, including the AstraZeneca team,
professors, and students, passionately debated whether science drives
technology or vice versa. Both sides presented compelling arguments,
ultimately arriving at a consensus that science plays a pivotal role
in enabling technology to drive research forward.
<br /><br />
To conclude the event, prizes were awarded to the winners of the
presentation segment, and memorable photos were captured with the
AstraZeneca team, marking a successful and enlightening event.
</p>
</div>
<div class="hpHeading">
<h1>An Introductory session on Genetic Circuits</h1>
</div>
<div class="hpText row">
<p class="col-lg-8">
As a part of our education and public outreach initiatives, we
organized an introductory educational event about genetic circuits.
The event was planned to be entirely beginner friendly and was divided
into two parts: an interactive presentation and an immersive problem
statement for attendees to reinforce their newly acquired concepts and
knowledge.
<br /><br />
The presentation was aimed at building upon concepts from level zero.
We went over basics of molecular biology like DNA structure,
complementary base pairing, the central dogma, the genetic code and
transcriptional regulation. This was done to bring everyone on the
same page prior to the discussion on genetic circuits.The latter part
of the presentation involved introducing simple examples like a
protein generator, an inverter, and the toggle switch. The discussion
then continued to acquaint the attendees with synthetic genetic logic
gates, the repressilator and the edge detector.
<br /><br />
A simple exercise was given to the participants for them to apply
their recently learned concepts on genetic circuits, it also served as
an outlet for them to acquaint themselves with the iGEM registry of
parts. The challenge involved designing a genetic circuit using the
iGEM Registry of Parts to build a biosensor sensitive to copper
contamination in water.
<br /><br />
Applications of genetic circuits in synthetic biology were discussed
in great depth along with the importance of synthetic biology in
solving real world problems. This was crucial in helping the attendees
truly appreciate the power of synthetic biology
</p>
</div>
<div class="hpHeading">
<h1>A meeting with Professor Victor de Lorenzo</h1>
</div>
<div class="hpText row">
<p class="col-lg-8">
Our lab team had the opportunity to interact with Dr. Victor de
Lorenzo, a highly esteemed synthetic biologist from the National
Biotechnology Center in Madrid, Spain. During the discussion we
presented our project idea in order to obtain his invaluable feedback
and insights.
<br /><br />
We were pleased to find that Dr. de Lorenzo was enthusiastic about our
proposal to develop a novel genetic engineering toolkit for an
unconventional chassis. Further, he expressed his satisfaction with
the progress our team had made up to that point in terms of laboratory
work as well as computational analysis.
<br /><br />
One of the key insights from the discussion was his suggestion to
incorporate the effect of species-specific RNases while building a
predictive model. These RNases, which are unique for different
species, may play a significant role in translation efficiency and
including their effect in the model could lead to more accurate
predictions. Additionally, Dr. de Lorenzo proposed the utilization of
an in vivo recombineering tool to expand the size and diversity of our
ribosome binding site (RBS) library. This would enable us to diversify
our toolkit more effectively.
<br /><br />
The meeting was an invaluable experience for our lab team and we are
deeply appreciative of his generosity in sharing his insights and
suggestions. The team is grateful for his enthusiasm and guidance,
which has not only enhanced the scope and relevance of our project but
has also left us inspired and motivated to further explore the
boundaries of synthetic biology.
</p>
</div>
<div class="hpHeading">
<h1>All-India iGEM Meet</h1>
</div>
<div class="hpText row">
<p class="col-lg-8">
Team iGEM IIT Madras along with teams from other institutes across the
country came together at the All India iGEM Meet 2023, held between
28th to 30th July at IISER Bhopal. It was a platform for the teams to
exchange ideas, receive feedback and foster collaboration, before the
Jamboree.
<br /><br />
During the judging session, the teams presented their project ideas
and progress. The feedback provided by the judges highlighted areas of
improvement and provided guidance for the further course of our
project.
<br /><br />
A poster presentation and interaction event was organized where the
teams discussed their project ideas and experiences. It involved
offering suggestions, asking questions, and providing constructive
feedback on each other's projects. This exchange of knowledge helped
teams to learn from each other's experiences and fostered a
collaborative environment, leading to new perspectives and
improvements in project design.
<br /><br />
During the convention, we had the opportunity to interact with
esteemed members of the iGEM community such as Dr. Lavanya
Bhagavatula, professor at IISER Bhopal, former Co-PI iGEM IISER Bhopal
as well as founder and CEO of Anvaya Biotech, Mr. Jeevan Subodh, iGEM
ambassador, Ms Shreya Kulkarni, member of iGEM startups and Ms. Sana
Jalili, former judge and iGEM promoter Asia and Oceania 23’.Their
invaluable insights and recommendations immensely contributed to the
enhancement of our project. One of the suggestions was to include a
proof of concept in the project explicitly in order to demonstrate the
feasibility and functionality of the project. They also recommended
validating our model software by comparing the predictions to actual
experimental data from the wet lab.
<br /><br />
It was a great networking opportunity, enabling us to build
connections with individuals from other institutes and experts in the
field, paving way for further collaborations and fostering a sense of
community among the iGEM teams.
</p>
</div>
</div>
</div>
{% endblock %}
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