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Commit 12b68f2f authored by Alexander Diefes's avatar Alexander Diefes
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Edited success rates section

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......@@ -781,12 +781,12 @@
<p>
With its current construction, the model implies that the process goes
to completion; that is, both ligand-dependent and ligand-independent
pathways successfully yield a released transcription factor for every
pathways successfully yield a released transcription factor for every synNotch
receptor. The current parameters that represent these processes only
influence the time-scales on which they occur. However, we know this not
to be true. There exist experimental data that show a certain proportion
of antibody ectodomain expression in the absence of ligand (Roybal et
al., 2016; Morsut et al., 2016). Thus, there must be success terms
of antibody ectodomain expression in the absence of ligand (Morsut et
al., 2016; Roybal et al., 2016). Thus, there must be success terms
implemented somewhere in this process, since the activation pathways do
not release all transcription factor. We introduce success rates for
both ligand-dependent and ligand-independent activation in our model. To
......@@ -804,7 +804,7 @@
<p>We use the following table to outline our procedure:</p>
<table>
<tr>
<th>"ligand concentration</th>
<th>"ligand concentration"</th>
<th>mCherry response (relative to total)</th>
<th>Linear relationship between \(\alpha\) and \(\beta\)</th>
<th>Parameter space of \(\alpha\) and \(\beta\)</th>
......@@ -816,14 +816,14 @@
<td>\[(\alpha, \beta) \in (0.67, 1) \times (0.50, 1)\]</td>
</tr>
<tr>
<td>\[$10^0 = 1$\]</td>
<td>\[10^{0} = 1\]</td>
<td>50%</td>
<td>\[\beta = -4.54 \alpha + 2.77\]</td>
<td>\[(\alpha, \beta) \in (0.39, 0.61) \times (0, 1)\]</td>
</tr>
<tr>
<td>\[10^{0.5} = 3.162\]</td>
<td>75&</td>
<td>75%</td>
<td>\[\beta = -14.18 \alpha + 3.79\]</td>
<td>\[(\alpha, \beta) \in (0.20, 0.27) \times (0, 1)\]</td>
</tr>
......
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