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Commit 9e6cbbda authored by sky's avatar sky
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static/description.css
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font-size: 1.1rem;
font-weight: 700;
margin: 20px 0 0 0;
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.content-div > strong {
.content-div strong {
font-weight: 700;
}
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wiki/pages/index.html
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<meta http-equiv="X-UA-Compatible" content="IE=edge">
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<title>Home | Sesame_Shenzhen - iGEM 2022</title>
<link rel="stylesheet" href="{{ url_for('static', filename='index.css') }}" />
<link rel="stylesheet" href="{{ url_for('static', filename='description.css') }}" />
{% include 'link.html' %}
</head>
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{% include 'menu.html' %}
<!-- 封图 -->
<div class="index-cover-box">
<img class="cover-img" src="https://static.igem.wiki/teams/4299/wiki/home/img1.jpg">
<div class="content-div">
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<p>In recent years, hyperuricemia in China has shown a significant increase and a younger trend. Complications that hyperuricemia and ventilation are highly likely to cause include hypertension, fatty liver, chronic kidney disease, and cardiovascular diseases.</p>
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<p>Our plan is to introduce the gene sequence encoding uric acid oxidase into E. coli and to introduce these microorganisms into some food products such as yogurt or probiotic lyophilized powder. When a patient takes these drinks, a portion of the E. coli in the drink will reside in the patient's intestine, and the strain will secrete uric acid oxidase and other cofactors. In this way, it can respond to uric acid concentrations over a long period of time. It decomposes the uric acid in the intestine, thus reducing the uric acid value in the body.</p>
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<img class="descrption-article-img" src="https://static.igem.wiki/teams/4299/wiki/home/img2.jpg">
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<p><strong>Sesame_Shenzhen</strong> consists of a total of 14 outstanding high school students from various schools. We have a strong interest in synthetic biology, and everyone on the team is an individual who can excel in various fields. We have a even distribution of tasks and complementary specialties, each with its own strengths.</p>
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<img class="descrption-article-img" src="https://static.igem.wiki/teams/4299/wiki/home/img3.jpg">
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<p>Our <strong>wet team</strong> is mainly responsible for participating in lab work, organizing experimental data, reading relevant literature, writing papers, and participating in collaborative exchanges in the experimental part. </p>
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<p>Our <strong>dry team</strong> is in charge of artwork design, PPT production, as well as a project-related human practice, education, questionnaire survey, creating mathematical modeling, and running social media of the team. </p>
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<iframe style="margin: 0 auto;" title="Sesame_Shenzhen: Uric acid lowering probiotic (2022) - Project Promotion [English]" width="784" height="441" src="https://video.igem.org/videos/embed/97d42ec4-e8ca-49d8-a753-7c7e668a2baa" frameborder="0" allowfullscreen="" sandbox="allow-same-origin allow-scripts allow-popups"></iframe>
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</div>
<!-- <div class="index-cover-box">
<img class="index-cover-gif" src="https://static.igem.wiki/teams/4299/wiki/home/75-share-lineal.gif" />
<div class="index-cover-title">HOME</div>
</div>
</div> -->
<!-- 内容 -->
<div data-aos="fade-up" class="index-content-box">
<!-- <div data-aos="fade-up" class="index-content-box">
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<div class="index-content-text-title">Sub TITLE</div>
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losses and serious disasters to all mankind. The novel coronavirus pandemic could
cost the global economy <b>82 trillion</b> in five years in a "recession" scenario,
according to the Risk Research Center at Cambridge Judges Business School.<b> More
than 230 million</b> people have been infected with COVID-19 and <b>more than 4
million</b> have died from it so far.
<p>In recent years, hyperuricemia in China has shown a significant increase and a younger trend. Complications that hyperuricemia and ventilation are highly likely to cause include hypertension, fatty liver, chronic kidney disease, and cardiovascular diseases.</p>
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<img class="index-content-gif" src="https://static.igem.wiki/teams/4299/wiki/home/75-share-lineal.gif" />
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million</b> have died from it so far.
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wiki/pages/model.html
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<!-- 侧边栏 -->
<div id="description-article-sidebar" class="">
<a class="article-sidebar-a" href="">
<!-- <a class="article-sidebar-a" href="">
<div class="">
Part.1
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<div class="">
Part.6
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</a>
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<!-- 内容 -->
<div class="content-div">
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<div class="descrption-article-text">
&nbsp;&nbsp;&nbsp;&nbsp;At present, people all over the world is facing a pandemic of novel coronavirus
pneumonia (COVID-19) caused
by novel coronavirus(SARS-CoV-2)[1]. The number of pademic cases and deaths worldwide is increasing, while
traditional vaccines and drug treatments are inevitably lagging behind. Therefore, in order to ensure human
life safety, this new threat makes people in urgen need of flexible and targeted protection measures. The
potential of CRISPR-Cas13d for novel coronavirus protection can provide us with new strategies to replace
traditional drugs or vaccines. According to recent research reports, several SARS-CoV-2 strains with
different genome sequences are spreading and evolving [2,3], which further highlights the need for targeted
strategies of coronavirus.
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<img class="descrption-article-img"
src="https://static.igem.wiki/teams/4299/wiki/bg1.jpeg">
<div class="article-img-description">
Fig.1. Novel coronavirus (from National Institutes of Health)
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<div class="descrption-article-text">
&nbsp;&nbsp;&nbsp;&nbsp;SARS-CoV-2 is also known as a novel coronavirus because of its numerous granular
processes at the edge of the virus particles. These granular processes are essentially a protein: Spike
Protein (S protein). This protein is closely related to the mechanism of coronavirus infection in
cells[2,3].
</div>
<img class="descrption-article-img"
src="https://static.igem.wiki/teams/4299/wiki/bg1.jpeg">
<div class="article-img-description">
Fig.2. Novel coronavirus structure
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<div class="descrption-article-text">
&nbsp;&nbsp;&nbsp;&nbsp;SARS-CoV-2 relies on ACE2 on human cells in the process of entering cells [4,5].
Angiotensin-converting enzyme 2 (ACE2) is widely expressed in the renal, cardiovascular and gastrointestinal
systems in humans, and also expressed in alveolar epithelial cells. ACE2 is involved in biological processes
such as blood pressure lowering, coagulation system balance, nutrient absorption and intestinal inflammatory
reactions. Receptor-Binding Domain (RBD) of S protein binds to ACE2 on the surface of human cells through
conformational matching, and then enters cells.
</div>
<img class="descrption-article-img"
src="https://static.igem.wiki/teams/4299/wiki/bg1.jpeg">
<div class="article-img-description">
Fig.3. S protein binding ACE2
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<div class="descrption-article-text">
&nbsp;&nbsp;&nbsp;&nbsp;In the process of virus infection, the spike protein binds to ACE2, and the host
cell secretes the corresponding protease to cut the spike protein of the virus, releasing the fusion peptide
and allowing the virus to enter the host cells. The cell membrane then adsorbs and internalizes the virus,
and the virus enters the cytoplasm, where it uncoats and releases its genome. After the genome is released
into the cytoplasm, the viral RNA binds to the ribosome of host cell and translates into proteins. The
proteins are then processed by protein hydrolase cleavage, and then assembled into new viruses.
</div>
<img class="descrption-article-img"
src="https://static.igem.wiki/teams/4299/wiki/bg1.jpeg">
<div class="article-img-description">
Fig.4. Hypothetical novel coronavirus life cycle
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<div class="article-refences">
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References
<script src="https://cdn.lordicon.com/xdjxvujz.js"></script>
<lord-icon src="https://cdn.lordicon.com/txmlvqat.json" trigger="hover" style="width:60px;height:60px">
</lord-icon>
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<div class="article-refences-item">
[1]X. Zhao et al., Polydatin protects against carbon tetrachloride-induced liver fibrosis in mice. Arch
Biochem Biophys 629, 1-7 (2017).
</div>
<div class="article-refences-item">
[2]X. Tang et al., On the origin and continuing evolution of SARS-CoV-2. National Science Review,
(2020).
</div>
<div class="article-refences-item">
[3]L. Du et al., The spike protein of SARS-CoV — a target for vaccine and therapeutic development.
Nature Reviews Microbiology 7, 226-236 (2009).
</div>
<div class="article-refences-item">
[4]H. Zhang et al., Digestive system is a potential route of COVID-19: an analysis of single-cell
coexpression pattern of key proteins in viral entry process. Gut 69, 1010 (2020).
</div>
</div>
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<embed src="https://static.igem.wiki/teams/4299/wiki/model/model.pdf">
<p>This browser does not support PDFs. Please download the PDF to view it: <a href="https://static.igem.wiki/teams/4299/wiki/model/model.pdf">Download PDF</a>.</p>
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