<pclass="content">We plan to deliver our circuit subcutaneously to generate a localized “tattoo” like pattern. This delivery can be achieved by either virus, which engineers somatic cells directly, or by injecting encapsulated engineered cells. And the following figure shows the specific working principle of these two methods.
<pclass="content"style="text-align:left;text-indent:0;"><emstyle="font-style:normal; font-size:0.7em; font-family:Comfortaa"><b>Figure 1 The working principle of implantation of encapsulated engineered cells and recombinant adeno-associated virus cells</b></em>
<pclass="content"style="text-align:left;text-indent:0;"><emstyle="font-style:normal; font-size:0.7em; font-family:Comfortaa"><b>Figure 1 The working principle of implantation of encapsulated engineered cells and recombinant adeno-associated virus cells.</b></em>
</p>
<pclass="content">Direct injection of encapsulated engineered cells is another widely-used approach to deliver synthetic gene circuits for therapeutic or diagnostic purposes. It has been reported that encapsulated designer cells can maintain functionality for months. Compared to the virus-based approaches, direct injection of encapsulated cells allows the pre-selection and testing of the engineered cells before actual injection, ensuring the robustness and effectiveness of the implant. However, the long-term survival of these designer cells and the potential inflammation raised by the encapsulated implant remains problematic.
