<pstyle="font-style: italic; color: white; margin-left: 10%;">Figure 1. Our first of many meetings with the Sydney 2022 iGEM team.</p>
<p>We found out that Sydney's project was very similar to what we were doing with our modeling project. We were developing an in silico approach to test nanobody binding affinity. On one hand, we were developing a high throughput nanobody folding (using an alpha fold-like algorithm) and docking approach. On the other hand, we were developing a code which can find nanobodies that bind to a given antigen input. This code makes use of sequences and certain chemical features (pH and hydrophobicity). The bottleneck of our modelling project consisted of the big nanobody synthetic library, for which we were implementing a clustering and filtering algorithm to reduce the size of our database to a more manageable size.</p>
<p>The Sydney team had the same objective that we set out with our modelling in the sense that we both were looking to generate a nanobody library in order to find the best binder to a given antigen. However, they were developing a nanobody library through a gene shuffling approach.</p>
<p>Considering that our aims were highly similar, we organized a collaboration between our two teams. With our collaboration, we set out to:</p"color:white;">
<p>Considering that our aims were highly similar, we organized a collaboration between our two teams. With our collaboration, we set out to:</pstyle="color:white;">
<li"color:white;">Input their nanobodies in our algorithms and find out whether our model also predicts similar binding affinities.</li>
<li"color:white;">Find out which nanobodies bind best to a given antigen, and look into whether we receive similar results experimentally.</li>
<listyle="color: white;">Input their nanobodies in our algorithms and find out whether our model also predicts similar binding affinities.</li>
<listyle="color: white;">Find out which nanobodies bind best to a given antigen, and look into whether we receive similar results experimentally.</li>
</ul>
<p>We conducted structure generation and docking with the data that the Sydney team has sent us, and shared our results with the Sydney team. We then were able to align our results, and uncovered some interesting findings.</p>
<p>For this collaboration, we submitted a self-drawn character that represented our project. We chose to make a cartoon of our genetically modified bacteria: <i"color:white;">limosilactobacillus reuteri</i>. They are the knight in shiny armor for the poultry industry and for us! Our knight represents us at Groningen in the global iGEM map, created by the <b>iGem team NTHU_Taiwan</b>. The global map was created to promote the <b>importance of synthetic biology</b> and show where all the experiments take place. Once you navigate over the map and you click on a character, a project description will pop-up and provide more information about that certain iGEM project. Our contribution can be seen in (figure 2).</p>
<p>For this collaboration, we submitted a self-drawn character that represented our project. We chose to make a cartoon of our genetically modified bacteria: <istyle="color: white;">limosilactobacillus reuteri</i>. They are the knight in shiny armor for the poultry industry and for us! Our knight represents us at Groningen in the global iGEM map, created by the <b>iGem team NTHU_Taiwan</b>. The global map was created to promote the <b>importance of synthetic biology</b> and show where all the experiments take place. Once you navigate over the map and you click on a character, a project description will pop-up and provide more information about that certain iGEM project. Our contribution can be seen in (figure 2).</p>
<buttonclass="collapsible"style="width:70%"><i>Figure 2. Our contribution to the NTHU Taiwan team.
<p>We received a request from a group consisting of the <b>iGEM teams from McGill, Cornell and Queen’s universities</b> regarding an educational booklet. For this we’ve collected several electron microscope images of our favorite bacteria (<i"color:white;">limosilactobacillus reuteri</i>), and some interesting/fun facts about it. This information we’ve submitted to their questionnaire from which they would make an educational booklet containing all the favorite bacteria for all partaking iGEM teams.</p>
<p>We received a request from a group consisting of the <b>iGEM teams from McGill, Cornell and Queen’s universities</b> regarding an educational booklet. For this we’ve collected several electron microscope images of our favorite bacteria (<istyle="color: white;">limosilactobacillus reuteri</i>), and some interesting/fun facts about it. This information we’ve submitted to their questionnaire from which they would make an educational booklet containing all the favorite bacteria for all partaking iGEM teams.</p>
