From 9d3a3beda1a961bc067fb82d93eabc2a2e4dd826 Mon Sep 17 00:00:00 2001
From: HouTeng Chan <ht-chen21@mails.tsinghua.edu.cn>
Date: Tue, 1 Oct 2024 21:32:11 +0000
Subject: [PATCH] Update file contribution.html
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<h3>Muscone-gated molecular switch in <i>Saccharomyces cerevisiae</i></h3>
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<img src="https://static.igem.wiki/teams/5187/wiki-contribution-fig/2.jpg" alt="ibd_figure" class="shadowed-image" style="width: 45%; max-width: 400px;">
- <p style="text-align: center; font-size: 0.9em; margin-top: 10px;">fig 1 The design of Muscone-gated molecular switch in <i>Saccharomyces cerevisiae</i></p>
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- <p>One of our standout contributions to synthetic biology tools is the construction of a Muscone-gated molecular switch in <i>Saccharomyces cerevisiae</i> BBa_K5187006. The muscone receptor is a type of GPCR derived from mice. We designed the corresponding Gα protein by modifying the amino acid sequence so that it can trigger the mating pathway in <i>Saccharomyces cerevisiae</i>, thereby further inducing the expression of downstream genes.</p>
+ <p>One of our standout contributions to synthetic biology tools is the construction of a Muscone-gated molecular switch in <i>Saccharomyces cerevisiae</i> <a href="https://parts.igem.org/Part:BBa_K5187006" style="color: #FF5151">BBa_K5187006</a>. The muscone receptor is a type of GPCR derived from mice. We designed the corresponding Gα protein by modifying the amino acid sequence so that it can trigger the mating pathway in <i>Saccharomyces cerevisiae</i>, thereby further inducing the expression of downstream genes.</p>
<p>It is worth noting that this molecular switch in <i>Saccharomyces cerevisiae</i> is an original contribution from our team. Although in our experiment it was applied to secrete lactic acid for the treatment of IBD, this downstream element can be replaced with any other gene to achieve different biological functions. We believe that this minute, efficient, and cost-effective molecular switch will have broad application scenarios in related industries.</p>
<p>Simultaneously, we have conducted molecular dynamics simulations to predict the binding of muscone molecules to their receptors, providing a more detailed and quantitative explanation of the biological process of the muscone-gated molecular switch. This aims to assist future research teams in obtaining more molecular dynamics information about this molecular switch and developing more functions of the switch. For more information, please refer to <a href="https://2024.igem.wiki/Tsinghua/model#topic2" style="color: #FF5151" >Model: Binding</a>.</p>
<p>For more information about the Muscone-gated molecular switch in <i>Saccharomyces cerevisiae</i>, please refer to <a href="https://2024.igem.wiki/Tsinghua/parts" style="color: #FF5151">Parts</a>.</p>
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