From 2b62ef9cb60c5827427dd49880b8158f91e3f2fd Mon Sep 17 00:00:00 2001
From: HouTeng Chan <ht-chen21@mails.tsinghua.edu.cn>
Date: Tue, 1 Oct 2024 12:37:25 +0000
Subject: [PATCH] Update file colonization.html
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<h2>Design</h2>
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<div class="image-container" style="display: flex; flex-direction: column; align-items: center;">
- <img src="https://static.igem.wiki/teams/5187/wiki-colonization-fig/pic1.jpg" alt="ibd_figure" class="shadowed-image" style="width: 100%; max-width: 1000px;">
+ <img src="https://static.igem.wiki/teams/5187/wiki-colonization-fig/1.png" alt="ibd_figure" class="shadowed-image" style="width: 80%; max-width: 800px;">
<p style="text-align: center; font-size: 0.9em; margin-top: 10px;">fig 1 Schematic Representation of colonization Experimental Design</p>
</div>
<p>To enable our engineered bacteria to specifically function at the small intestinal lesions in IBD patients, we designed the colonization system. This system consists of two main components: one is the tetrathionate sensor TtrSR, and the other is the adhesion protein Als3. TtrSR is a two-component system from the marine bacterium Shewanella halifaxensis HAW-EB4, which can detect extracellular tetrathionate chemical signals and promote the expression of downstream genes in the signaling pathway. Als3 is a cell surface protein from Candida albicans, which acts as an adhesin, mediating adhesion to epithelial cells, endothelial cells, and extracellular matrix proteins. We chose Saccharomyces cerevisiae as the chassis organism for engineering the bacteria. By expressing the TtrSR system and Als3 protein in Saccharomyces cerevisiae, we will achieve specific colonization at the small intestinal lesions in IBD patients.</p>
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