From c0118d0fa10d1fab92e52f1afb9b3ccaeb8d8c11 Mon Sep 17 00:00:00 2001
From: Isabell Guckes <isabell.guckes@uni-bielefeld.de>
Date: Sun, 29 Sep 2024 10:45:09 +0200
Subject: [PATCH] =?UTF-8?q?=C3=BCbergabe?=
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---
src/contents/engineering.tsx | 7 ++++---
1 file changed, 4 insertions(+), 3 deletions(-)
diff --git a/src/contents/engineering.tsx b/src/contents/engineering.tsx
index 9fcb632d..c158a093 100644
--- a/src/contents/engineering.tsx
+++ b/src/contents/engineering.tsx
@@ -521,7 +521,7 @@ export function Engineering() {
<H4 text="Conclusion" id="text" />
We use DMG-PEG2000 in our SORT LNP-based AirBuddy because of its superior biodegradability, enhanced stability, and reduced risk of immune system activation. By building on insights from experts and incorporating principles from Wang’s LNP work, we’ve tailored our nanoparticles for lung-specific delivery. This choice ensures that our formulations remain stable long enough to deliver the therapeutic payload effectively while minimizing potential long-term toxicity. This balance is crucial for pulmonary applications, where DMG-PEG2000 outperforms alternatives like mPEG-2000-DSPE, making it the ideal choice for treating CFTR-related lung diseases.
{/* <H4 text="text" id="text" />
- erster absatz
+ <p>erster absatz</p>
<p>zweiter absatz</p> */}
</p>
</Collapsible>
@@ -534,8 +534,9 @@ export function Engineering() {
</figcaption>
</figure>
<Collapsible id="Col2" open={false} title="Composition of our SORT LNP called Airbuddy">
- <H4 text="text" id="text" />
- erster absatz
+ <p>Our lung-specific formulation uses <strong>Selective Organ-Targeting (SORT) LNPs</strong> [1], optimized for stability, targeting, and delivery efficiency. Combined with the <strong>spray-drying technique</strong>, our LNP <strong>AirBuddy</strong> offers an efficient way to deliver mRNA therapeutics to the lungs. The successful delivery of the prime editing complex via inhalation is key to our project.</p>
+ <H4 text="Components of AirBuddy" id="text" />
+ <p>erster absatz</p>
<p>zweiter absatz</p>
</Collapsible>
<p>The final innovation for our LNP to become <strong>AirBuddy</strong> came through consultation with Benjamin Winkeljann from <a onClick={() => goToPagesAndOpenTab('rnhale', '/human-practices')}> RNhale</a>, where the use of spray-drying techniques was discussed. Spray-drying the LNPs, instead of using traditional methods, helped improve stability and eco-friendliness of the product [8]. The spray-dried SORT LNPs demonstrated lower cytotoxicity, and the technique proved effective in maintaining particle integrity.</p>
--
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