From d36f1c2226efa1d465a7f0a8ed2bd1a2ed5db459 Mon Sep 17 00:00:00 2001
From: Shraddha <ShraddhaRaghuram@student.tudelft.nl>
Date: Tue, 24 Sep 2024 17:02:52 +0200
Subject: [PATCH] background and problem
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<div class="h1">Make LAMPS more smart and reliable</div>
<p>In addition to better realizing the fluorescence function itself, we further explored the design of <b>synthetic biology</b> and <b>biocybernetics</b> in enhancing the application capabilities of engineering cyanobacteria.</p>
<p>We hope to make LAMPS "smart", capable of automatically turning on after entering the night and automatically turning off during the day without the need for manual control. Fortunately, cyanobacteria, as photoautotrophic organisms, have an inherent biological clock rhythm system. Through a series of protein interactions and phosphorylation modifications, it can generate oscillatory outputs in downstream promoter PkaiBC with a 24-hour cycle. <sup>[4,5]</sup></p>
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<p>We expressed nuclease A(nucA) under a constitutive promoter and linked its inhibitor gene, nuiA, downstream of a Ni ion-responsive promoter. When a certain concentration of Ni ions is added to the culture medium, it induces continuous expression of nuiA, allowing the microorganisms to survive. However, once the microorganisms leak and leave the culture medium, the concentration of Ni ions in the environment decreases, nucA is derepressed, and it cuts the DNA of cyanobacteria, leading to their death. <sup>[8]</sup> This design achieves automatic sterilization in the event of a leak and eliminates the need for manual handling.</p>
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<div class="h1">Anticipate application scenarios and address climate issues</div>
<p>Considering the commercial feasibility and the value transformation of the technology, we worked with industrial design students to do some scenario exploration and product development with our technology.</p>
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<p>These two applications amplify the product benefits of biomaterials and combine the technical characteristics of LAMPS. This product makes our technology commercially viable and provides a promising value conversion path for this technology.</p>
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<div class="h1">Reference</div>
<p style="text-align:left;">[1] Kaku T, Sugiura K, Entani T, Osabe K, Nagai T. Enhanced brightness of bacterial luciferase by bioluminescence resonance energy transfer. Sci Rep. 2021;11(1):14994. Published 2021 Jul 22. doi:10.1038/s41598-021-94551-4</p>
<p style="text-align:left;">[2] Brodl, Eveline et al. “The impact of LuxF on light intensity in bacterial bioluminescence.†Journal of photochemistry and photobiology. B, Biology vol. 207 (2020): 111881. doi:10.1016/j.jphotobiol.2020.111881</p>
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