From b4f3898910e864c25a456ff9985db9665553cb24 Mon Sep 17 00:00:00 2001
From: HouTeng Chan <ht-chen21@mails.tsinghua.edu.cn>
Date: Tue, 1 Oct 2024 20:06:09 +0000
Subject: [PATCH] Update file proof-of-concept.html
---
wiki/pages/proof-of-concept.html | 15 +++++++--------
1 file changed, 7 insertions(+), 8 deletions(-)
diff --git a/wiki/pages/proof-of-concept.html b/wiki/pages/proof-of-concept.html
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<h4>Communication with relevant social stakeholders</h4>
<p>We discussed using Saccharomyces cerevisiae as the chassis organism for our project with Dr. Liu Zhihua. Professor Liu affirmed our design of using Saccharomyces cerevisiae as the chassis organism and pointed out that Saccharomyces cerevisiae is distributed in the human intestinal environment, being a relatively harmless and safe microorganism to humans, making it very suitable as the chassis organism for our project.</p>
<p>We discussed the type of engineered strain of Saccharomyces cerevisiae with Dr. Li Peng. Professor Li recommended that we use the MAT alpha genotype strain, which has nutritional deficiencies in his, leu, lys, and ura. This strain can be used for transformation and screening during the project's experimental process and prevent safety threats from biological leakage.</p>
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<h2 id="Refernece">
<h2>Refernece</h2>
<hr>
- <p>[1] Wu X, Yu Y, Wang M, Dai D, Yin J, Liu W, Kong D, Tang S, Meng M, Gao T, Zhang Y, Zhou Y, Guan N, Zhao S, Ye H. AAV-delivered muscone-induced transgene system for treating chronic diseases in mice via inhalation. Nat Commun. 2024 Feb 6;15(1):1122. doi: 10.1038/s41467-024-45383-z. PMID: 38321056; PMCID: PMC10847102.</p>
- <p>[2] Scott BM, Gutiérrez-Vázquez C, Sanmarco LM, da Silva Pereira JA, Li Z, Plasencia A, Hewson P, Cox LM, O'Brien M, Chen SK, Moraes-Vieira PM, Chang BSW, Peisajovich SG, Quintana FJ. Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease. Nat Med. 2021 Jul;27(7):1212-1222. doi: 10.1038/s41591-021-01390-x. Epub 2021 Jun 28. PMID: 34183837.</p>
- <p>[3] Sanmarco LM, Rone JM, Polonio CM, Fernandez Lahore G, Giovannoni F, Ferrara K, Gutierrez-Vazquez C, Li N, Sokolovska A, Plasencia A, Faust Akl C, Nanda P, Heck ES, Li Z, Lee HG, Chao CC, Rejano-Gordillo CM, Fonseca-Castro PH, Illouz T, Linnerbauer M, Kenison JE, Barilla RM, Farrenkopf D, Stevens NA, Piester G, Chung EN, Dailey L, Kuchroo VK, Hava D, Wheeler MA, Clish C, Nowarski R, Balsa E, Lora JM, Quintana FJ. Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells. Nature. 2023 Aug;620(7975):881-889. doi: 10.1038/s41586-023-06409-6. Epub 2023 Aug 9. PMID: 37558878; PMCID: PMC10725186.</p>
- <p>[4] Levitt MD, Furne J, Springfield J, Suarez F, DeMaster E. Detoxification of hydrogen sulfide and methanethiol in the cecal mucosa. J Clin Invest. 1999 Oct;104(8):1107-14. doi: 10.1172/JCI7712. PMID: 10525049; PMCID: PMC408582.</p>
- <p>[5] Daeffler KN, Galley JD, Sheth RU, Ortiz-Velez LC, Bibb CO, Shroyer NF, Britton RA, Tabor JJ. Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation. Mol Syst Biol. 2017 Apr 3;13(4):923. doi: 10.15252/msb.20167416. PMID: 28373240; PMCID: PMC5408782.</p>
- <p>[6] Wächtler B, Citiulo F, Jablonowski N, Förster S, Dalle F, Schaller M, Wilson D, Hube B. Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process. PLoS One. 2012;7(5):e36952. doi: 10.1371/journal.pone.0036952. Epub 2012 May 14. PMID: 22606314; PMCID: PMC3351431.</p>
- <p>[7] Jiang L, Zhang H, Xiao D, Wei H, Chen Y. Farnesoid X receptor (FXR): Structures and ligands. Comput Struct Biotechnol J. 2021 Apr 20;19:2148-2159. doi: 10.1016/j.csbj.2021.04.029. Erratum in: Comput Struct Biotechnol J. 2022 Mar 01;20:1227-1228. doi: 10.1016/j.csbj.2022.02.029. PMID: 33995909; PMCID: PMC8091178.</p>
+ <p style="font-size: 0.7em;">[1] Wu X, Yu Y, Wang M, Dai D, Yin J, Liu W, Kong D, Tang S, Meng M, Gao T, Zhang Y, Zhou Y, Guan N, Zhao S, Ye H. AAV-delivered muscone-induced transgene system for treating chronic diseases in mice via inhalation. Nat Commun. 2024 Feb 6;15(1):1122. doi: 10.1038/s41467-024-45383-z. PMID: 38321056; PMCID: PMC10847102.</p>
+ <p style="font-size: 0.7em;">[2] Scott BM, Gutiérrez-Vázquez C, Sanmarco LM, da Silva Pereira JA, Li Z, Plasencia A, Hewson P, Cox LM, O'Brien M, Chen SK, Moraes-Vieira PM, Chang BSW, Peisajovich SG, Quintana FJ. Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease. Nat Med. 2021 Jul;27(7):1212-1222. doi: 10.1038/s41591-021-01390-x. Epub 2021 Jun 28. PMID: 34183837.</p>
+ <p style="font-size: 0.7em;">[3] Sanmarco LM, Rone JM, Polonio CM, Fernandez Lahore G, Giovannoni F, Ferrara K, Gutierrez-Vazquez C, Li N, Sokolovska A, Plasencia A, Faust Akl C, Nanda P, Heck ES, Li Z, Lee HG, Chao CC, Rejano-Gordillo CM, Fonseca-Castro PH, Illouz T, Linnerbauer M, Kenison JE, Barilla RM, Farrenkopf D, Stevens NA, Piester G, Chung EN, Dailey L, Kuchroo VK, Hava D, Wheeler MA, Clish C, Nowarski R, Balsa E, Lora JM, Quintana FJ. Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells. Nature. 2023 Aug;620(7975):881-889. doi: 10.1038/s41586-023-06409-6. Epub 2023 Aug 9. PMID: 37558878; PMCID: PMC10725186.</p>
+ <p style="font-size: 0.7em;">[4] Levitt MD, Furne J, Springfield J, Suarez F, DeMaster E. Detoxification of hydrogen sulfide and methanethiol in the cecal mucosa. J Clin Invest. 1999 Oct;104(8):1107-14. doi: 10.1172/JCI7712. PMID: 10525049; PMCID: PMC408582.</p>
+ <p style="font-size: 0.7em;">[5] Daeffler KN, Galley JD, Sheth RU, Ortiz-Velez LC, Bibb CO, Shroyer NF, Britton RA, Tabor JJ. Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation. Mol Syst Biol. 2017 Apr 3;13(4):923. doi: 10.15252/msb.20167416. PMID: 28373240; PMCID: PMC5408782.</p>
+ <p style="font-size: 0.7em;">[6] Wächtler B, Citiulo F, Jablonowski N, Förster S, Dalle F, Schaller M, Wilson D, Hube B. Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process. PLoS One. 2012;7(5):e36952. doi: 10.1371/journal.pone.0036952. Epub 2012 May 14. PMID: 22606314; PMCID: PMC3351431.</p>
+ <p style="font-size: 0.7em;">[7] Jiang L, Zhang H, Xiao D, Wei H, Chen Y. Farnesoid X receptor (FXR): Structures and ligands. Comput Struct Biotechnol J. 2021 Apr 20;19:2148-2159. doi: 10.1016/j.csbj.2021.04.029. Erratum in: Comput Struct Biotechnol J. 2022 Mar 01;20:1227-1228. doi: 10.1016/j.csbj.2022.02.029. PMID: 33995909; PMCID: PMC8091178.</p>
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