diff --git a/wiki/pages/colonization.html b/wiki/pages/colonization.html index 5be0dad6f41f1131ecea5d14e6af4dfc53cdc1c8..2149b76ed0e121925180a4caf02dda7f78b29559 100644 --- a/wiki/pages/colonization.html +++ b/wiki/pages/colonization.html @@ -57,7 +57,7 @@ <h2>Design</h2> <hr> <div class="image-container" style="display: flex; flex-direction: column; align-items: center;"> - <img src="https://static.igem.wiki/teams/5187/wiki-colonization-fig/1.png" alt="ibd_figure" class="shadowed-image" style="width: 80%; max-width: 800px;"> + <img src="https://static.igem.wiki/teams/5187/wiki-colonization-fig/1.png" alt="ibd_figure" class="shadowed-image" style="width: 100%; max-width: 1000px;"> <p style="text-align: center; font-size: 0.9em; margin-top: 10px;">fig 1 Schematic Representation of colonization Experimental Design</p> </div> <p>To enable our engineered bacteria to specifically function at the small intestinal lesions in IBD patients, we designed the colonization system. This system consists of two main components: one is the tetrathionate sensor TtrSR, and the other is the adhesion protein Als3. TtrSR is a two-component system from the marine bacterium Shewanella halifaxensis HAW-EB4, which can detect extracellular tetrathionate chemical signals and promote the expression of downstream genes in the signaling pathway. Als3 is a cell surface protein from Candida albicans, which acts as an adhesin, mediating adhesion to epithelial cells, endothelial cells, and extracellular matrix proteins. We chose Saccharomyces cerevisiae as the chassis organism for engineering the bacteria. By expressing the TtrSR system and Als3 protein in Saccharomyces cerevisiae, we will achieve specific colonization at the small intestinal lesions in IBD patients.</p> @@ -73,7 +73,7 @@ <p>Signal pathway - TtrRS two-component system</p> <p>Output signal - Als3 adhesion protein</p> <div class="image-container" style="display: flex; flex-direction: column; align-items: center;"> - <img src="https://static.igem.wiki/teams/5187/wiki-colonization-fig/pic2.png" alt="ibd_figure" class="shadowed-image" style="width: 60%; max-width: 600px;"> + <img src="https://static.igem.wiki/teams/5187/wiki-colonization-fig/pic2.png" alt="ibd_figure" class="shadowed-image" style="width: 80%; max-width: 800px;"> <p style="text-align: center; font-size: 0.9em; margin-top: 10px;">fig 2 Schematic Diagram of colonization System</p> </div> </div> diff --git a/wiki/pages/therapy-system.html b/wiki/pages/therapy-system.html index f0758d3b01285d5db6fc41a2aa3e8ada54970ba8..2a11cbbaa9174960ed6cb1b4eeeb88b143e9e969 100644 --- a/wiki/pages/therapy-system.html +++ b/wiki/pages/therapy-system.html @@ -66,7 +66,7 @@ <h2>Design</h2> <hr> <div class="image-container" style="display: flex; flex-direction: column; align-items: center;"> - <img src="https://static.igem.wiki/teams/5187/wiki-therapysystem-fig/fig1.png" alt="ibd_figure" class="shadowed-image" style="width: 80%; max-width: 800px;"> + <img src="https://static.igem.wiki/teams/5187/wiki-therapysystem-fig/fig1.png" alt="ibd_figure" class="shadowed-image" style="width: 100%; max-width: 1000px;"> <p style="text-align: center; font-size: 0.9em; margin-top: 10px;">fig 1 Schematic Representation of our Experimental Design</p> </div> <p>We introduced muscone gas molecule receptors derived from mouse olfactory epithelial cells into chassis bioengineered bacteria. The muscone gas molecule receptor is a G protein coupled receptor in eukaryotic cells, and we chose Saccharomyces cerevisiaet as the chassis bioengineering bacterium. By modifying the mating pathway of Saccharomyces cerevisiae, the muscone gas molecule receptor is integrated into the signaling pathway of Saccharomyces cerevisiae. And downstream of the modified mating pathway, lactate dehydrogenase was introduced to alter the anaerobic metabolism pathway of Saccharomyces cerevisiae, synthesizing lactate for the treatment of IBD disease.</p> @@ -82,7 +82,7 @@ <p>Signaling pathway - Saccharomyces cerevisiae mating pathway </p> <p>Output signal - Lactic acid secretion </p> <div class="image-container" style="display: flex; flex-direction: column; align-items: center;"> - <img src="https://static.igem.wiki/teams/5187/wiki-therapysystem-fig/fig2.png" alt="ibd_figure" class="shadowed-image" style="width: 60%; max-width: 600px;"> + <img src="https://static.igem.wiki/teams/5187/wiki-therapysystem-fig/fig2.png" alt="ibd_figure" class="shadowed-image" style="width: 80%; max-width: 800px;"> <p style="text-align: center; font-size: 0.9em; margin-top: 10px;">fig 2 Schematic Diagram of the Therapy System</p> </div> </div>