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         <b>ICG (Indocyanine Green)</b> is a notable example of a standalone NIR probe that has been approved by the FDA for clinical use. It is the only NIR-I dye currently authorized for applications like fluorescence-guided surgery and vascular imaging. Despite its regulatory approval and widespread use, ICG also suffers from many of the limitations inherent to NIR probes. Its fluorescence signal can be weak, and its poor stability in vivo leads to rapid clearance by the liver and kidneys, which restricts its imaging potential. Additionally, ICG lacks strong target specificity, resulting in low accumulation at target sites and high background signals, which can impair the quality of imaging.
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+        <img src="https://static.igem.wiki/teams/5209/images/des/description-pic5.webp" width="20%" alt="description5" onmouseover="mouse_over_on_img()" onmouseout="mouse_out_on_img()">
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