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Engineering genomes in the third dimension
The cells in our body come in many forms and functions despite sharing the same genomic sequence.
The DNA sequence is only the first dimension of how life is encoded.
The 3D structure of the genome
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determines the interpretation of the sequence.
plays a role in the distinction between humans and the great apes.
can make the difference between health and disease.
Although the 3D genome organization is intensively studied, it remains nearly impossible to engineer.
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That is why we introduce
PICasSO
and its Digital Twin
DaVinci
Our Toolbox allows to:
Program any DNA-DNA interaction of your choice
using our extensive part collection.
Investigate and prevent disease related genome rearrangements, such as enhancer hijacking in cancer.
Precisely model the interactions in silico
for rapid adaption in the wet lab.