From ca1c93b078228c896e110d62bdb36660f7aa03b3 Mon Sep 17 00:00:00 2001
From: Kaya <kaya.lange@uni-bielefeld.de>
Date: Wed, 4 Dec 2024 13:11:29 +0100
Subject: [PATCH] hp timeline
---
src/data/hptimelinedata.tsx | 44 ++++++++++++++++++++++---------------
1 file changed, 26 insertions(+), 18 deletions(-)
diff --git a/src/data/hptimelinedata.tsx b/src/data/hptimelinedata.tsx
index 92d84d0..215f993 100644
--- a/src/data/hptimelinedata.tsx
+++ b/src/data/hptimelinedata.tsx
@@ -121,7 +121,6 @@ const pics: { [key: string]: string } = {
grandjambooree: "https://static.igem.wiki/teams/5247/photos/hp/grand-jamboree.webp",
prizes: "https://static.igem.wiki/teams/5247/thaw/2024-preise.webp",
frontiers: "https://static.igem.wiki/teams/5247/photos/hp/frontiers.webp",
- hygiene: "https://static.igem.wiki/teams/5247/photos/hp/hygiene-concept.webp",
homecoming: "https://static.igem.wiki/teams/5247/photos/hp/homecoming.webp",
};
@@ -528,7 +527,7 @@ export const timelinedata: Array<TimelineDatenpunkt> = [
insights: "The interview yielded valuable insights into the regular implementation of the therapy, the use of aids and the adaptation of exercises to the individual needs of the patients. It was notable that the therapy has improved over the last years, considerably thanks to better medication and adapted exercises, with a concomitant increase in life expectancy for children affected by CF. Of particular interest was the emphasis on the importance of sport and exercise, which should not only be therapeutically effective, but also increase quality of life. ",
implementation: [<p>The following statement by Katrin Westhoff had a particular impact on our project: ‘The more we know, the more options we have’. We learnt from the interview that the current medication is already helping many patients very well, but that there is still great potential for improvement. Successful gene therapy would significantly improve the quality of life of CF patients. We implemented the findings from this interview in our participation in <HPLinktoOtherHPTab tab="mukomove" text="MukoMove" />- we actively took part in Cystic Fibrosis awareness month and learnt even more about the importance of physiotherapy.</p>],
pictureurl_interview: "https://static.igem.wiki/teams/5247/photos/hp/katrin-westhoff-zoom.webp",
- summary: [<p>The objective of our discussion with a therapist was to gain a comprehensive understanding of the treatment and care of children with Cystic Fibrosis. The interview provided invaluable insights into the therapy's implementation, highlighting the significant advancements in medication and tailored exercises that have led to improved patient outcomes and increased life expectancy. A key takeaway was the emphasis on the role of sports and exercise, not just for therapeutic efficacy but also for enhancing overall quality of life. It let to our participation in the CF awarness month and the outreach project mukomove {/* [Link mukomove] */}</p>],
+ summary: [<p>The objective of our discussion with a therapist was to gain a comprehensive understanding of the treatment and care of children with Cystic Fibrosis. The interview provided invaluable insights into the therapy's implementation, highlighting the significant advancements in medication and tailored exercises that have led to improved patient outcomes and increased life expectancy. A key takeaway was the emphasis on the role of sports and exercise, not just for therapeutic efficacy but also for enhancing overall quality of life. It let to our participation in the CF awarness month and the outreach project <OurLink path='human-practices'tabId='mukomove' text="MUKOmove"/></p>],
months: "May",
interview:<>
<QaBox q="From what age do the patients come to you? How long do they stay? How many patients do you treat?" a="The patients come to us at a very early age. A definite diagnosis is made after 6 weeks at the latest. Once diagnosed, the whole family is genetically tested, and children are sent for physiotherapy, often starting in the hospital. Currently, we have 8 children with CF in our practice, which is relatively small compared to other diseases. We have slightly more CF patients because we specialize in it."/>
@@ -624,9 +623,14 @@ export const timelinedata: Array<TimelineDatenpunkt> = [
quoteNachname: "Susat, Teammember",
quoteVorname: "Kathleen",
quote: "It was amazing to see how movement can bring people together. I had a great time.",
- summary: [<p>MUKOmove{/* [LINK unten mukomove] */} is a sports initiative by Mukoviszidose e.V., the German Cystic Fibrosis Association, to raise awareness and funds for Cystic Fibrosis. Team iGEM Bielefeld participated from May 8th to May 12th, promoting the event at their university and city, encouraging others to join and collect sport hours. They organized a team event at their university, involving sports games to promote community engagement. Their efforts helped surpass their goal of 240 hours, with the team achieving 358 sport hours, while the entire event gathered over 36,000 sport hours. The initiative successfully raised awareness about Cystic Fibrosis and promoted physical activity as a means of community building.</p>],
- months: "May"
- },
+ summary: [<p><OurLink path='human-practices'tabId='mukomove' text="MUKOmove"/> is a sports initiative by Mukoviszidose e.V., the German Cystic Fibrosis Association, to raise awareness and funds for Cystic Fibrosis. Team iGEM Bielefeld participated from May 8th to May 12th, promoting the event at their university and city, encouraging others to join and collect sport hours. They organized a team event at their university, involving sports games to promote community engagement. Their efforts helped surpass their goal of 240 hours, with the team achieving 358 sport hours, while the entire event gathered over 36,000 sport hours. The initiative successfully raised awareness about Cystic Fibrosis and promoted physical activity as a means of community building.
+ <br></br>
+ <br></br>
+ <br></br>
+ <iframe title="Bielefeld-CeBiTec: Muko-Move (2024) [English]" width="560" height="315" src="https://video.igem.org/videos/embed/3503f3ce-dabb-4f6b-b80f-2a3534cf51c2" frameBorder="0" sandbox="allow-same-origin allow-scripts allow-popups allow-forms"></iframe>
+ </p>],
+ months: "May",
+ },
{
title: "M.Sc.",
vorname: "Jan-Phillipp",
@@ -758,7 +762,7 @@ export const timelinedata: Array<TimelineDatenpunkt> = [
<b>Survey Insights:</b> Many participants were motivated to try gene therapies but lacked knowledge about them and Cystic Fibrosis, highlighting the need for better public education.
</li>
<li>
- <b>Awareness Campaign:</b> Partnered with Mukoviszidose e.V. Deutschland to support the Muko Move campaign, raising awareness about Cystic Fibrosis in the local community.
+ <b>Awareness Campaign:</b> Partnered with Mukoviszidose e.V. Deutschland to support the <OurLink path='human-practices'tabId='mukomove' text="MUKOmove"/> campaign, raising awareness about Cystic Fibrosis in the local community.
</li>
<li>
<b>Scientific Advancements:</b> Improved the efficiency of Prime Editing by incorporating a novel RNA structural element, with further efforts to optimize the Prime Editing protein complex for broader applicability beyond Cystic Fibrosis.
@@ -943,7 +947,8 @@ export const timelinedata: Array<TimelineDatenpunkt> = [
insights: [<p>During our time at Achema, we gained valuable insights into life sciences, with a strong focus on LNP production and lab best practices. Our discussions with experts, including Jutta from a life science company, provided us with innovative solutions and cutting-edge techniques. Her insights into current trends helped us better understand how to advance our project.</p>,
<p>Through various expert interactions, we deepened our knowledge of LNP production, learning key manufacturing techniques essential for developing effective therapeutics. These insights allowed us to optimize our production methods, ensuring more efficient processes moving forward.</p>,
<p>Understanding rigorous quality control processes was another key takeaway, enabling us to implement checks that will boost the reliability and safety of our therapeutics. These comprehensive insights have not only supported our current goals but also prepared us for future challenges, equipping us with the tools to navigate the complexities of research and therapeutic development.</p>],
- implementation: [<p>Discussions with industry experts have provided invaluable insights into the production of LNPs{/* [LINK LNPcycle] */}, a crucial aspect of our project. We have identified innovative manufacturing techniques and quality control procedures that we can integrate into our processes. This knowledge not only supports our immediate objectives but also positions us to overcome future challenges in developing effective therapies.</p>],
+ implementation: [<p>Discussions with industry experts have provided invaluable insights into the production of <OurLink path='engineering'tabId='delivery' scrollToId='del1head' text="LNPs"/>
+ , a crucial aspect of our project. We have identified innovative manufacturing techniques and quality control procedures that we can integrate into our processes. This knowledge not only supports our immediate objectives but also positions us to overcome future challenges in developing effective therapies.</p>],
summary: [<p>During discussions with industry experts at Achema 2024, we gained valuable insights that will have a significant impact on our project and provide us with innovative manufacturing techniques and quality control procedures that we are now integrating into our workflows. These insights will help us to optimise our production processes to achieve more efficient and reliable results in therapeutic development. The new knowledge supports our current goals and prepares us for future challenges in the development of effective therapies</p>],
months: "jun",
pictureurl_aim:"https://static.igem.wiki/teams/5247/photos/hp/achema1.webp",
@@ -1053,8 +1058,8 @@ export const timelinedata: Array<TimelineDatenpunkt> = [
the measurement of the membrane potential above and below a monolayer of confluent cells<ScrollLinkWithChild targetId="desc-3"><sup>3</sup></ScrollLinkWithChild>. Consequently,
it enables precise measurement of conductivity dependent on CFTR expression. </p>
</>],
- implementation: [<p>We decided to use HEK293T{/*[Link]*/} cells lines which do overexpress the
- correct CFTR and those which express CFTR with F508del mutation for the Patch-Clamp measurements{/*LINK Methodspatchclamp*/}. To conduct the
+ implementation: [<p>We decided to use <OurLink path='materials-methods' scrollToId='introduction' text="HEK293T"/> cells lines which do overexpress the
+ correct CFTR and those which express CFTR with F508del mutation for the <OurLink path='materials-methods' scrollToId='introduction' text="Patch-Clamp measurements"/>. To conduct the
Patch-Clamp experiments, we contacted the Cellular Neurophysiology group to perform the necessary
measurements. It was a pleasure to work together with, who is working as a post-doc for
the Cellular Neurophysiology working group at Bielefeld University. He taught us about the Patch-Clamp
@@ -1195,7 +1200,7 @@ export const timelinedata: Array<TimelineDatenpunkt> = [
<li>Using Ala or Gly for substitution</li>
<li>Development of a nickase assay</li>
</ul>,
- <p>We developed our mutation candidates on this basis. {/*[link zum Cycle oder New Part ?]*/}</p>
+ <p>We developed our <OurLink path='engineering'tabId='nickase' scrollToId='nic1head' text="mutation candidates"/> on this basis.</p>
],
summary: "In our discussion with Prof. Dr. Hammer, we explored several theoretical approaches in enzyme engineering, including PAM engineering, chimeric proteins, Phage-Assisted Continuous Evolution (PACE), and rational design involving zinc-finger mutations. We evaluated the potential of using structural simulations with AlphaFold 3 and the construction of chimeric proteins. The conversation highlighted the importance of analyzing homologous mechanisms through sequence alignments to identify structural similarities in catalytic centers. We also discussed targeted mutations, such as substitutions to alanine, and the development of a nickase assay. Overall, we concluded that transferring mutations to homologous proteins is a promising rational approach for optimizing enzyme function.",
months: "jul"
@@ -1453,13 +1458,14 @@ export const timelinedata: Array<TimelineDatenpunkt> = [
vorname: "'Schüler*innen Akademie'",
nachnname: "",
pictureurl: pics['schueler'],
+ job: "Team iGEM",
+ affiliation: "Bielfeld CeBiTec 2024",
tag: "Education",
heading: "Empowering students through synthetic biology",
interviewtabid: "schueler",
type: "meta",
-
- quoteVorname: "Kaya",
- quoteNachname: "Lange, Teamm",
+ quoteVorname: "Lisa",
+ quoteNachname: "Wiesner, Teammember",
quote: "It was wonderful to be part of the Student Academy and to experience how much we learned while teaching. Sharing our knowledge and seeing the students' enthusiasm was incredibly rewarding, even though we couldn't convey everything in just one session.",
summary: [<p>The CeBiTec Student Academy at Bielefeld University provides high school students with hands-on experience in biotechnology and molecular biology, supported by the Osthushenrich Foundation and Detmold district government. iGEM Bielefeld participated by guiding students through a nanopore sequencing experiment, teaching them about lab work, experiment preparation, and safety protocols. The team also presented their iGEM project, PreCyse, giving students insight into real-world research projects and synthetic biology. Many students were excited by the iGEM concept and expressed interest in joining during their future studies. Overall, the academy helped inspire students to explore STEM fields and gain practical scientific skills.</p>],
months: "aug"
@@ -1567,19 +1573,20 @@ export const timelinedata: Array<TimelineDatenpunkt> = [
nachnname: "Beckmann",
job: "Patient and Student",
affiliation: "University Bielefeld",
- pictureurl: pics['hygiene'],
+ pictureurl: pics['max'],
tag: "Patient",
heading: "Consultation on University Hygiene Risks and Improvement for Hygiene Concept",
interviewtabid: "maxhygiene",
-
language: "de",
quoteNachname:"Beckmann, Patient",
quoteVorname: "Max",
quote: "It’s important to keep my hygiene practices practical and effective, focusing on regular cleaning rather than excessive measures that may create more risks for invection.",
summary: [<p>Inspired by <HPLinktoOtherHPTab tab="maxfirst" text="Max's" /> feedback on the unique challenges faced by individuals with immunocompromised systems, we initiated the development of a specialized <OurLink path='contribution' scrollToId='hygiene-concept' text="hygiene concept"/>. Max’s insights provided invaluable guidance in addressing the specific needs of cystic fibrosis (CF) patients and others with weakened immune systems. His input emphasized practical measures to ensure a safer and more hygienic environment in public spaces, particularly in university restrooms.
Through detailed discussions with Max, we developed guidelines that balance rigorous hygiene with feasibility. His feedback highlighted that while regular cleaning and essential facilities like toilet lids are crucial, overly complex measures, such as contactless systems, may not be necessary if proper hand hygiene is maintained. He praised the initial points of the concept as thoughtful and effective, further refining our approach to focus on high-impact solutions.
- To ensure a robust and comprehensive framework, we sought additional review and advice from <HPLinktoOtherHPTab tab="johannfunke" text="Johann Funke" /> . By incorporating Max’s feedback and Johann's expertise, we aim to create a practical hygiene protocol that addresses the needs of immunocompromised individuals, making university spaces safer and more inclusive. </p>],
- months: "aug"
+ To ensure a robust and comprehensive framework, we sought additional review and advice from <HPLinktoOtherHPTab tab="johannfunke" text="Johann Funke" /> . By incorporating Max’s feedback and Johann's expertise, we aim to create a practical hygiene protocol that addresses the needs of immunocompromised individuals, making university spaces safer and more inclusive.
+ </p>],
+ months: "aug",
+ pictureurl_implementation: "https://static.igem.wiki/teams/5247/photos/hp/hygiene-concept.webp",
},
{
title: "Dr.",
@@ -1655,7 +1662,8 @@ export const timelinedata: Array<TimelineDatenpunkt> = [
tag: "Industry",
heading: "Successful participation of a team member in a 5 day GxP course",
interviewtabid: "gxpcourse",
-
+ job: "Team iGEM",
+ affiliation: "Bielfeld CeBiTec 2024",
quote: "The GXP course was extremely useful as it provided us with important knowledge that supports our entire team in complying with quality standards. This knowledge will help us to organise our processes efficiently and in accordance with regulations in the future.",
quoteVorname:"Kaya",
quoteNachname:"Lange, Teammember",
--
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