From a7a484350d740141a5b0949f6ee44ce05a2a0b26 Mon Sep 17 00:00:00 2001
From: Kaya <kaya.lange@uni-bielefeld.de>
Date: Fri, 27 Sep 2024 16:34:18 +0200
Subject: [PATCH] changes svenja
---
src/data/hptimelinedata.tsx | 21 +++++++++++++++------
1 file changed, 15 insertions(+), 6 deletions(-)
diff --git a/src/data/hptimelinedata.tsx b/src/data/hptimelinedata.tsx
index 7cdd9be9..9895eb48 100644
--- a/src/data/hptimelinedata.tsx
+++ b/src/data/hptimelinedata.tsx
@@ -53,6 +53,8 @@ const pics: { [key: string]: string } = {
kuehnel: "https://static.igem.wiki/teams/5247/photos/hp/hp-philippk-hnel.jpeg ",
wischmeyer: "https://static.igem.wiki/teams/5247/photos/hp/wischmeyer-erhard.webp",
nicole: "https://static.igem.wiki/teams/5247/photos/hp/hp-friedlein-nicole.jpg",
+ joshua: "https://static.igem.wiki/teams/5247/photos/hp/joshua.jpg",
+ hammer: "https://static.igem.wiki/teams/5247/photos/hp/hp-hammer.webp",
};
/* {
@@ -655,7 +657,7 @@ export const timelinedata: Array<TimelineDatenpunkt> = [
nachnname: "Bauder",
job: "parent and activist",
affiliation: "CF vests worldwide",
- pictureurl: pics['placeholder'],
+ pictureurl: pics['joshua'],
tag: "Patient",
heading: "Interview with a CF Parent and Global Advocate on Worldwide Support and Perspectives",
interviewtabid: "joshua",
@@ -892,7 +894,7 @@ export const timelinedata: Array<TimelineDatenpunkt> = [
nachnname: "Hammer",
job: "Junior Professor of Organic Chemistry and Biocatalysis",
affiliation: "Universität Bielefeld",
- pictureurl: pics['placeholder'],
+ pictureurl: pics['hammer'],
tag: "Academia",
heading: "Safety Briefing and Laboratory Practices Advice",
interviewtabid: "hammer",
@@ -934,10 +936,17 @@ export const timelinedata: Array<TimelineDatenpunkt> = [
cardtext: "",
language: "de",
quote: "",
- aimofcontact: "",
-
- insights: "",
- implementation: "",
+ aimofcontact: [<p>We contacted Svenja Vinke, a former iGEMer from Bielefeld, to get her insight and her opinion regarding the use of phage assisted continuous evolution
+ (PACE, see engineering cycle 1[Link]) for our prime editing optimizations. Svenja works at the iGEM Safety and Security Committee. Additionally, she was part of the Biosafety and Security Award Team of Bielefeld University in 2016.</p>],
+ insights: [<p>Svenja explained, that a PACE approach is not feasible to use for optimization of our nickase candidates because of several reasons:</p>,
+ <ul>
+ <li>Implementing a PACE system takes way too much time to use for our project.</li>
+ <li>Endonucleases might be too big to optimize using PACE.</li>
+ <li>Unspecific cutting or nicking in the bacterial genome kills the cells, which makes optimization of endonucleases very challenging.</li>
+ <li>Prime editing in E. coli cells is less effective compared to human cells, which might impair the evolution process.</li>
+ </ul>
+ ] ,
+ implementation: [<p>On the basis of Svenja’s and other opinions on the topic, we decided not to try implementing a PACE system. </p>],
},
{
vorname: "Max",
--
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