From 92223c6f6284ad0a3fa50a6978786e13f7b306e8 Mon Sep 17 00:00:00 2001
From: Liliana Sanfilippo <lsanfilippo@techfak.uni-bielefeld.de>
Date: Fri, 15 Nov 2024 19:13:20 +0100
Subject: [PATCH] =?UTF-8?q?Medikamente=20Schriftfarbe=20=C3=A4ndern,=20evt?=
=?UTF-8?q?.=20zsmh=C3=A4ngend=20mit=20Quellen=3F?=
MIME-Version: 1.0
Content-Type: text/plain; charset=UTF-8
Content-Transfer-Encoding: 8bit
---
src/data/drug-data.tsx | 14 +++++++-------
1 file changed, 7 insertions(+), 7 deletions(-)
diff --git a/src/data/drug-data.tsx b/src/data/drug-data.tsx
index 831fb429..89bc69ad 100644
--- a/src/data/drug-data.tsx
+++ b/src/data/drug-data.tsx
@@ -35,30 +35,30 @@ export const drugdata: (Array<DrugDatensatz>) = [
//gibt 4 Modulator Beispiele
name: "Modulators",
picture: "https://static.igem.wiki/teams/5247/scientific-figures/modulators.svg",
- introduction: <a>CFTR modulators represent a significant advancement in CF treatment since they are small molecules improving the function of the defective CFTR protein in a mutation-specific way, which helps restore chloride ion transport across cell membranes. Notable pharmaceutical agents include Trikafta®, Symdeko®, Orkambi® and Kalydeco® <SupScrollLink label="74"/>. These medications have been demonstrated to significantly improve lung function and reduce pulmonary exacerbations. However, they are expensive and may cause side effects such as liver enzyme elevations and cataracts in pediatric patients <SupScrollLink label="75"/>. Furthermore, they are not suitable for all CF patients since only mutations which produce a CFTR channel can be supported by CFTR modulators, not those mutations which lead to a missing CFTR channel (knock out) <SupScrollLink label="74"/>, e.g. stop-mutations including p.Arg553Ter or p.Gly542Ter<SupScrollLink label="76"/>. </a>,
+ introduction: <>CFTR modulators represent a significant advancement in CF treatment since they are small molecules improving the function of the defective CFTR protein in a mutation-specific way, which helps restore chloride ion transport across cell membranes. Notable pharmaceutical agents include Trikafta®, Symdeko®, Orkambi® and Kalydeco® <SupScrollLink label="74"/>. These medications have been demonstrated to significantly improve lung function and reduce pulmonary exacerbations. However, they are expensive and may cause side effects such as liver enzyme elevations and cataracts in pediatric patients <SupScrollLink label="75"/>. Furthermore, they are not suitable for all CF patients since only mutations which produce a CFTR channel can be supported by CFTR modulators, not those mutations which lead to a missing CFTR channel (knock out) <SupScrollLink label="74"/>, e.g. stop-mutations including p.Arg553Ter or p.Gly542Ter<SupScrollLink label="76"/>. </>,
examples: [
{
title: "Trikafta", //quelle 4
- text: [<a>Active ingredient(s): Combination of elexacaftor/tezacaftor/ivacaftor","Indications: For CF patients aged 2 years and older with at least one F508del mutation = 85 % of CF patients","Mechanism: Elexacaftor and tezacaftor act as correctors on misfolded CFTR and permit delivery to the cell surface, thereby improving the channel density at the plasma membrane, while ivacaftor as a potentiator acts on CFTR channels that have reached the cell surface and increase the gating and conductance of ions <SupScrollLink label="77"/>","Administration: Oral tablets</a>,"Approval: Approved by the EMA in 2020 "]
+ text: [<>Active ingredient(s): Combination of elexacaftor/tezacaftor/ivacaftor","Indications: For CF patients aged 2 years and older with at least one F508del mutation = 85 % of CF patients","Mechanism: Elexacaftor and tezacaftor act as correctors on misfolded CFTR and permit delivery to the cell surface, thereby improving the channel density at the plasma membrane, while ivacaftor as a potentiator acts on CFTR channels that have reached the cell surface and increase the gating and conductance of ions <SupScrollLink label="77"/>","Administration: Oral tablets</>,"Approval: Approved by the EMA in 2020 "]
},
{
title: "Symdeko", //quelle 1
- text: ["Active ingredient(s): Combination of tezacaftor and ivacaftor","Indications: For CF patients aged 6 years and older with specific mutations in combination with F508del or with two copies of F508del mutation", <a>Mechanism: Tezacaftor acts as a corrector on misfolded CFTR and permit delivery to the cell surface, thereby improving the channel density at the plasma membrane, while ivacaftor as a potentiator acts on CFTR channels that have reached the cell surface and increase the gating and conductance of ions <SupScrollLink label="77"/> </a>, "Administration: Oral tablets", "Approval: Approved by the EMA in 2018"]
+ text: ["Active ingredient(s): Combination of tezacaftor and ivacaftor","Indications: For CF patients aged 6 years and older with specific mutations in combination with F508del or with two copies of F508del mutation", <>Mechanism: Tezacaftor acts as a corrector on misfolded CFTR and permit delivery to the cell surface, thereby improving the channel density at the plasma membrane, while ivacaftor as a potentiator acts on CFTR channels that have reached the cell surface and increase the gating and conductance of ions <SupScrollLink label="77"/> </>, "Administration: Oral tablets", "Approval: Approved by the EMA in 2018"]
},
{
title: "Orkambi", //quelle 6
- text: ["Active ingredient(s): Combination of lumacaftor and ivacaftor", "Indications: For CF patients aged 1 year and older with two copies of the F508del mutation",<a>Mechanism: Lumacaftor acts as a corrector on misfolded CFTR and permit delivery to the cell surface, thereby improving the channel density at the plasma membrane, while ivacaftor as a potentiator act on CFTR channels that have reached the cell surface and increase the gating and conductance of ions <SupScrollLink label="77"/></a>,"Administration: Oral tablets","Approval: Approved by the EMA in 2015"]
+ text: ["Active ingredient(s): Combination of lumacaftor and ivacaftor", "Indications: For CF patients aged 1 year and older with two copies of the F508del mutation",<>Mechanism: Lumacaftor acts as a corrector on misfolded CFTR and permit delivery to the cell surface, thereby improving the channel density at the plasma membrane, while ivacaftor as a potentiator act on CFTR channels that have reached the cell surface and increase the gating and conductance of ions <SupScrollLink label="77"/></>,"Administration: Oral tablets","Approval: Approved by the EMA in 2015"]
},
{
title: "Kalydeco", //quelle 7
- text: ["Active ingredient(s): Ivacaftor","Indications: For CF patients aged 4 months and older with a gating mutation in the CFTR gene (excluding F508del)",<a>Mechanism: Ivacaftor as a potentiator acts on CFTR channels that have reached the cell surface and increase the gating and conductance of ions <SupScrollLink label="77"/></a>,"Administration: Oral tablets","Approval: Approved by the EMA in July 2012"]
+ text: ["Active ingredient(s): Ivacaftor","Indications: For CF patients aged 4 months and older with a gating mutation in the CFTR gene (excluding F508del)",<>Mechanism: Ivacaftor as a potentiator acts on CFTR channels that have reached the cell surface and increase the gating and conductance of ions <SupScrollLink label="77"/></>,"Administration: Oral tablets","Approval: Approved by the EMA in July 2012"]
},
]
},
{
name: "Mucolytics and inhalation", //gibt 2 Inhalation Beispiele
picture: "https://static.igem.wiki/teams/5247/scientific-figures/mucolytics.svg",
- introduction: <a>Mucolytics help thin and loosen the mucus in the lungs, making it easier to cough up and clear the airways. These therapies are typically administered via wet or dry inhalation, providing direct delivery to the lungs. In the case of wet inhalation, the medication is inhaled as an aqueous solution and nebulized, while in the case of dry inhalation, the medication is inhaled as a powder. <SupScrollLink label="74"/> Key Therapies include mannitol, Pulmozyme® and hypertonic saline.</a>,
+ introduction: <>Mucolytics help thin and loosen the mucus in the lungs, making it easier to cough up and clear the airways. These therapies are typically administered via wet or dry inhalation, providing direct delivery to the lungs. In the case of wet inhalation, the medication is inhaled as an aqueous solution and nebulized, while in the case of dry inhalation, the medication is inhaled as a powder. <SupScrollLink label="74"/> Key Therapies include mannitol, Pulmozyme® and hypertonic saline.</>,
examples: [
{
title: "Pulmozyme", //quelle 8
@@ -88,7 +88,7 @@ export const drugdata: (Array<DrugDatensatz>) = [
{
name: "Digestive enzymes and diet", //ein beispiel
picture: "https://static.igem.wiki/teams/5247/scientific-figures/diet.svg",
- introduction: <a> The digestive process is impaired in 80% of patients with cystic fibrosis (CF), as a result of pancreatic insufficiency, which in turn leads to difficulties in digesting food and absorbing nutrients. Enzyme supplements like Creon® are therefore essential [16]. Moreover CF patients are also advised to eat a balanced and energy-rich diet, as the increased work of breathing and increased coughing, as well as infections, fever and diarrhoea, consume more energy than a healthy person. <SupScrollLink label="74"/> It is also an option for patients to use nutritional supplements. Electrolyte preparations are also used in this context to compensate for the increased need for fluids and the required salts.</a>,
+ introduction: <> The digestive process is impaired in 80% of patients with cystic fibrosis (CF), as a result of pancreatic insufficiency, which in turn leads to difficulties in digesting food and absorbing nutrients. Enzyme supplements like Creon® are therefore essential [16]. Moreover CF patients are also advised to eat a balanced and energy-rich diet, as the increased work of breathing and increased coughing, as well as infections, fever and diarrhoea, consume more energy than a healthy person. <SupScrollLink label="74"/> It is also an option for patients to use nutritional supplements. Electrolyte preparations are also used in this context to compensate for the increased need for fluids and the required salts.</>,
examples: [
{
title: "Creon", //quelle 17
--
GitLab