From 33b5cd703831304a35337766e914955edd965527 Mon Sep 17 00:00:00 2001
From: Liliana Sanfilippo <lsanfilippo@techfak.uni-bielefeld.de>
Date: Mon, 2 Dec 2024 17:56:57 +0100
Subject: [PATCH] =?UTF-8?q?Judging=20Feeback=20hinzuf=C3=BCgen?=
MIME-Version: 1.0
Content-Type: text/plain; charset=UTF-8
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---
src/contents/judging.tsx | 87 ++++++++++++++++++++++++++++++++++++++++
src/pages.ts | 5 +++
src/sidebars/jugS.tsx | 3 +-
3 files changed, 94 insertions(+), 1 deletion(-)
diff --git a/src/contents/judging.tsx b/src/contents/judging.tsx
index d2dff108..ee3cd9a1 100644
--- a/src/contents/judging.tsx
+++ b/src/contents/judging.tsx
@@ -1,3 +1,4 @@
+import { H3, H4 } from "../components/Headings";
import { BlockQuoteB } from "../components/Quotes";
import { Section } from "../components/sections";
import { useNavigation } from "../utils";
@@ -122,6 +123,92 @@ export function Judging() {
<iframe title="Bielefeld-CeBiTec: Judging Session (2024)" width="560" height="315" src="https://video.igem.org/videos/embed/d90ef3d2-1bb5-426e-8ab7-8e644d1a22a5" frameBorder="0" allowFullScreen sandbox="allow-same-origin allow-scripts allow-popups allow-forms"></iframe>
</div>
</div>
+ <H3 text="Judging Feedback" id="Judging Session1"></H3>
+ <H4 text="Judge 1"></H4>
+ <div className="row feedbackbfh">
+ <div className="col b-lg">
+ <ul>
+ <li>
+ I could see engineering principles and mindsets even in the presentation video. It is a very well-engineered and designed project. Every progress started with some hypotheses. The team tested many hypotheses; many didn’t work but they were able to learn and improve.
+ </li>
+ <li>
+ Documentation is very detailed in general. Specifically, the project description comes with reviews of cystic fibrosis and some basic terms so that anyone with basic molecular biology knowledge would be able to understand the project. The graphics, where there are, also facilitate understanding of technology.
+ </li>
+ <li>
+ The human practices are amazing, significantly influencing key project decisions. They went beyond obvious issues (e.g., how health insurance might cover gene therapies, ethics associated with handling patient-derived cells, biobank), showing compelling evidence that it is responsible and good. The same can be said on the team’s safety work.
+ </li>
+ </ul>
+ </div>
+ <div className="col b-lo">
+ <ul>
+ <li>
+ I don’t see how the proposed new basic part BBa_K5247135 can be useful for the wider community. It is designed with a very specific purpose in mind, of which the characterization is also not done in calibrated units. Basically, one can test different pegRNAs for the F508del mutation in the CFTR gene with fluorescence of the internal positive control arbitrarily set as 100%.
+ </li>
+ <li>
+ I appreciate the extensive documentation of human practices. The way different feedback or research was incorporated is clear but the rationale for the stakeholders chosen is not always clear. It becomes sort of a laundry list of everything that affected the team with too many sections and subtitles.
+ </li>
+ <li>
+ I’m impressed by the fact that the team has access to some sophisticated technology like cryogenic electron microscopy but it’s not clear why these characterizations are necessary, i.e., what the research question is. In fact, the team would then observe various problems associated with these methods. For example, “for SEM analysis, the samples were dried and observed under vacuum, which probably have affected the structure and shape of the LNPs.†If this is the case, then why would the team do it from the beginning?
+ </li>
+ <li>
+ The contributions of the safety work (i.e. primary cultures, biosafety measures, innovative safety mechanisms and regulatory compliance), particularly to what extent they build on existing resources and standards, particularly those from the iGEM community, are not very clear.
+ </li>
+</ul>
+
+ </div>
+ </div>
+
+ <H4 text="Judge 2"></H4>
+ <div className="row feedbackbfh">
+ <div className="col b-lg">
+ <p>I enjoyed browsing through the Wiki, very clear and easy to understand and consume. Commendable demonstration of human practices and good integration of feedback. The Project Presentation is professionally done, enjoyable to watch. I highly encourage the tactic of team members walking around and engaging with judges/other teams. I loved the confidence. Wiki has mobile version, which is well appreciated. </p>
+ </div>
+ <div className="col b-lo">
+ <p>I enjoyed the Calendar feature in Project Documentation, but the dates did not always work. There are still some Lorem Ipsum paragraphs remaining (Results, for instance). Visuals in the Registry part are too big and are not well visible.</p>
+ </div>
+ </div>
+
+ <H4 text="Judge 3"></H4>
+ <div className="row feedbackbfh">
+ <div className="col b-lg">
+ <p>Very well done team Bielefed-CeBiTec. I thought that your project design was very well thought out and was able to clearly see the impact on quality of life that your project would help restore in CF patients. Over the course of this past year, you have done an impressive amount of work, and I think tailoring your project to not only focus on accuracy of your guide RNA but also ensuring the best possible delivery mechanisms to ensure cell uptake was a smart move if you were to track this for market. I also appreciated just how thorough your wiki presents your work, and the amount of effort put into your human practices, engaging with not only members of academia and healthcare, but actual people living with CF. Each page sufficiently attributed and cited original ideas, and the flow from top to bottom of the page made logical sense and made my life as a judge easier. Well done overall, and best of luck as you continue working with this!</p>
+ </div>
+ <div className="col b-lo">
+ <p>There were a couple of notes that stood out to me regarding your wiki and promotional video that I would like to highlight for next year's team. With your individual part designs and part pages, I did not see sufficient data within the part page itself to get excited about the work and how the part can help future iGEMers. Based on your wiki, I know you did a lot of testing and have the capacity to demonstrate part success; however, remember to present your research items in a way that is mindful to someone who is outside of your experimental realm. Ask yourself the following questions: 1) What specifically was successful about my part design? 2) If quantifying data and showing that data in another means (e.g. microscopy images) do these images match? 3) What caveats and troubleshooting would be necessary to bring this part further? Another note, and it is minor, but in your human practices and promotion of the BFH European meetup, you bring attention to connections and participation by two high-profile iGEM members (Nemanja - VP, Tracy - Former Director of Judging). While it is okay to demonstrate their attendance (using videos of them, describing what they do), it feels borderline like favoritism in that they were showing up to your event, in particular with you highlighting their attendance, not necessarily what they presented on and how it impacted you and the other teams in attendance. Be mindful of this going forward.</p>
+ </div>
+ </div>
+
+ <H4 text="Judge 4"></H4>
+ <div className="row feedbackbfh">
+ <div className="col b-lg">
+ <p>Your project is very good; I like the approach, as we are used to seeing more invasive approaches in medicine. Your project was also very well defended; you answered the questions confidently, which caught my attention. You never hesitated. It was a lot of work, and you managed to shape it well. I hope you can continue with the project and turn it into a startup</p>
+ </div>
+ <div className="col b-lo">
+ <p>It would be useful to delve into the potential challenges related to the biocompatibility and degradability of chitosan nanoparticles in the human body, as ensuring long-term safety and efficacy is essential for therapies of this kind. It would also be interesting to explore methods and experiments to further improve the stability of the nanoparticles, evaluate different pH conditions, and determine which peripheral cells or tissues could be harmed or could benefit. Let's remember that the human body is not an isolated system; many of these interactions may lead to allergies, unwanted responses, or affect the organism's suitability. Cultivating peripheral tissues with the same system would also be a very intriguing approach.</p>
+ </div>
+ </div>
+
+ <H4 text="Judge 5"></H4>
+ <div className="row feedbackbfh">
+ <div className="col b-lg">
+ <p>You demonstrated a strong commitment to biosafety by outlining detailed safety protocols and addressing both environmental and human health risks. Your proactive approach to identifying potential hazards and implementing safety measures highlights your responsibility in managing synthetic biology risks. Great work!</p>
+ </div>
+ <div className="col b-lo">
+ <p>Your Materials and Methods section provides a solid foundation of your technical work, but could benefit from more detailed explanations of some experimental design choices. Additionally, including a section that discusses challenges encountered and how you have addressed it would offer valuable insights for future teams attempting to replicate or build on yourwork. This would also help illustrate the adaptability and problem-solving aspects of your project</p>
+ </div>
+ </div>
+
+
+ <H4 text="Judge 6"></H4>
+ <div className="row feedbackbfh">
+ <div className="col b-lg">
+ <p>The integration of Prime Editing and the AirBuddy delivery system showcases a cutting-edge approach to gene therapy. This not only demonstrates technical innovation but also highlights your commitment to improving treatment efficacy and precision.</p>
+
+ </div>
+ <div className="col b-lo">
+ <p>While the therapy aims for long-term correction, discussing how you plan to evaluate durability and stability of the genetic correction over time could provide a clearer understanding of the treatment’s potential benefits.</p>
+ </div>
+ </div>
</Section>
</>
diff --git a/src/pages.ts b/src/pages.ts
index 16216979..21be9215 100644
--- a/src/pages.ts
+++ b/src/pages.ts
@@ -401,6 +401,11 @@ export const NavPages: (Page | PageRef | Folder)[] = [
title: "Judging",
path: "/judging?scrollTo=best-new-basic-part",
},
+ {
+ name: "Judging Session",
+ title: "Judging",
+ path: "/judging?scrollTo=judging-session",
+ },
]
},
{
diff --git a/src/sidebars/jugS.tsx b/src/sidebars/jugS.tsx
index 187f796b..ed938286 100644
--- a/src/sidebars/jugS.tsx
+++ b/src/sidebars/jugS.tsx
@@ -15,5 +15,6 @@ const tabs = [
{tab: "Best Integrated Human Practice"},
{tab: "Safety & Security"},
{tab: "Best New Basic Part"},
- {tab: "Conclusion"}
+ {tab: "Conclusion"},
+ {tab: "Judging Session"}
];
--
GitLab