From d82f0d3374f2ceaafc46d8b98b7f4ee44cc5e9f6 Mon Sep 17 00:00:00 2001
From: Haobin Zhu <robinzhb@stu.pku.edu.cn>
Date: Thu, 12 Oct 2023 15:19:37 +0000
Subject: [PATCH] Update 3.description.md

---
 content/3.description.md | 10 +++++-----
 1 file changed, 5 insertions(+), 5 deletions(-)

diff --git a/content/3.description.md b/content/3.description.md
index 15d2d10..c57afac 100644
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@@ -10,7 +10,7 @@
 
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-Nowadays, cancer is one of the most pressing health challenges, among which pancreatic cancer has earned the title of "the king of cancer" due to its alarmingly low five-year survival rate[$^1$](#references). According to the statistics of China's National Cancer Center[$^2$](#references) and GLOBOCAN 2020[$^3$](#references), pancreatic cancer ranks 7th in the incidence rate of malignancy in males and 11th in females, and 6th in the mortality rate in China (<b><font color=#8B0012>Fig.1</font></b>). In America, pancreatic cancer has become the fourth-leading cause of cancer mortality[$^4$](#references), and is projected to become the second-leading cause of cancer death in the next twenty to thirty years[$^5$](#references).
+Cancer remains one of today's most pressing health challenges, with pancreatic cancer notably referred to as 'the king of cancer' due to its alarmingly low five-year survival rate[$^1$](#references). According to the statistics of China's National Cancer Center[$^2$](#references) and GLOBOCAN 2020[$^3$](#references), pancreatic cancer ranks 7th in the incidence rate of malignancy in males and 11th in females, and 6th in the mortality rate in China (<b><font color=#8B0012>Fig.1</font></b>). In America, pancreatic cancer is currently the fourth-leading cause of cancer-related deaths and is projected to rise to the second-leading cause within the next two to three decades[$^5$](#references).
 
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@@ -26,7 +26,7 @@ Nowadays, cancer is one of the most pressing health challenges, among which panc
 
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-​Pancreatic cancer has several subtypes, of which pancreatic ductal adenocarcinoma (PDAC) is the most common malignancy[$^7$](#references). Unfortunately, conventional treatment methods have shown limited efficacy in combatting PDAC due to the complex anatomical surroundings of the pancreas and immune escape (<b><font color=#8B0012>Fig.2</font></b>). Moreover, with highly aggressive nature, pancreatic cancer is characterized by its demonstrating perineural and vascular local growth, as well as early distant metastases that often prevent curative surgical resection in the majority of patients[$^5$](#references). All of the factors mentioned above collectively contribute to the disheartening reality that the 5-year survival rate for pancreatic cancer has not shown significant improvement over the past few decades.
+​Among several subtypes of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC) stands out as the most common form of this malignancy[$^7$](#references). Unfortunately, conventional treatment methods have shown limited efficacy in combatting PDAC due to the complex anatomical surroundings of the pancreas and immune escape (<b><font color=#8B0012>Fig.2</font></b>). Moreover, with highly aggressive nature, pancreatic cancer is characterized by its demonstrating perineural and vascular local growth, as well as early distant metastases that often prevent curative surgical resection in the majority of patients[$^5$](#references). All of the factors mentioned above collectively contribute to the disheartening reality that the 5-year survival rate for pancreatic cancer has not shown significant improvement over the past few decades.
 
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@@ -44,7 +44,7 @@ Nowadays, cancer is one of the most pressing health challenges, among which panc
 
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-​Excitingly, the application of neoadjuvant therapy has injected new vitality into the treatment of pancreatic cancer. Notably, stereotactic body radiation therapy (SBRT) is regarded as an emerging radiotherapy technique, capable of achieving high local control rates with acceptable toxicity[$^{10,11}$](#references). However, SBRT requires precise spatial localization of the tumour and potential metastatic lesions to plan the target area; otherwise, unexpected side effects outside the target area may occur. At present, positron emission tomography (PET) is extensively employed for monitoring the situation of tumours in clinical practice, including size, infiltration, and distant metastasis. It uses specialized radioactive glucose probes ($^{18}$F-fludeoxyglucose, $^{18}$F-FDG) or other probes to differentiate them from normal tissues, capitalizing on the characteristic high metabolic activity of tumours[$^{12}$](#references). However, after the injection of imaging agents, some patients may experience side effects such as nausea, allergies, gastrointestinal reactions, and in very rare cases, even fatalities. Additionally, conditions like inflammation and autoimmune diseases may manifest similar heightened metabolic responses to tumours, thus complicating the differential diagnosis process. The substantial costs associated with infrastructure and examination fees present yet another noteworthy hindrance to its broad adoption.
+​Excitingly, the application of neoadjuvant therapy has injected new vitality into the treatment of pancreatic cancer. Notably, stereotactic body radiation therapy (SBRT) is regarded as an emerging radiotherapy technique, capable of achieving high local control rates with acceptable toxicity[$^{10,11}$](#references). However, SBRT necessitates precise spatial localization of both the tumor and potential metastatic lesions for accurate targeting, failing which, unexpected side effects may occur outside the intended area. At present, positron emission tomography (PET) is extensively employed for monitoring the situation of tumours in clinical practice, including size, infiltration, and distant metastasis. It uses specialized radioactive glucose probes ($^{18}$F-fludeoxyglucose, $^{18}$F-FDG) or other probes to differentiate them from normal tissues, capitalizing on the characteristic high metabolic activity of tumours[$^{12}$](#references). However, after the injection of imaging agents, some patients may experience side effects such as nausea, allergies, gastrointestinal reactions, and in very rare cases, even fatalities. Additionally, conditions like inflammation and autoimmune diseases may manifest similar heightened metabolic responses to tumours, thus complicating the differential diagnosis process. The substantial costs associated with infrastructure and examination fees present yet another noteworthy hindrance to its broad adoption.
 
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@@ -52,7 +52,7 @@ Nowadays, cancer is one of the most pressing health challenges, among which panc
 
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-​On the other hand, live bacteria therapy is emerging as a promising strategy in the field of cancer treatment. Some bacteria, such as *Escherichia coli*, *Salmonella*, and *Listeria*, possess innate tumour-targeting capabilities[$^{13}$](#references). Compared with most other therapeutics, the effectiveness of tumour-targeting bacteria remains unaffected by the ‘genetic makeup’ of a tumour[$^{14}$](#references). As microscopic ‘robotic factories’, bacterial vectors can be reprogrammed to produce and deliver anticancer agents on the basis of clinical needs, serving as potent weapons for eradicating tumours. When complementing other anticancer therapies, it could achieve better clinical outcomes.
+​On the other hand, live bacteria therapy is emerging as a promising strategy in the field of cancer treatment. Some bacteria, such as *Escherichia coli*, *Salmonella*, and *Listeria*, possess innate tumour-targeting capabilities[$^{13}$](#references). Unlike most therapeutics, tumor-targeting bacteria maintain their effectiveness regardless of a tumor's genetic makeup[$^{14}$](#references). As microscopic ‘robotic factories’, bacterial vectors can be reprogrammed to produce and deliver anticancer agents on the basis of clinical needs, serving as potent weapons for eradicating tumours. When complementing other anticancer therapies, it could achieve better clinical outcomes.
 
 ​Thus, Peking 2023 is devoted to advancing bacterial therapy and introducing innovative modifications to revolutionize pancreatic cancer treatment.
 
@@ -111,7 +111,7 @@ Nowadays, cancer is one of the most pressing health challenges, among which panc
 
 <font size=3 color=grey>
 
-**Figure 5 | ​The schematic diagram of dynamic circuit[$^{17}$](#references).** By controlling the strength and duration of arabinose induction, we aim to achieve the desired effect as "iCAP" shown in the figure, while minimizing toxicity reactions in the organism as much as possible.
+**Figure 5 | ​The schematic diagram of dynamic circuit[$^{17}$](#references).** By modulating the intensity and duration of arabinose induction, we aim to replicate the 'iCAP' effect depicted in the figure, with a concerted effort to minimize potential toxic reactions within the organism.
 
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