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@@ -44,7 +44,7 @@ Nowadays, cancer is one of the most pressing health challenges, among which panc
 
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-​Excitingly, the application of neoadjuvant therapy has injected new vitality into the treatment of pancreatic cancer. Notably, stereotactic body radiation therapy (SBRT) is regarded as an emerging radiotherapy technique, capable of achieving high local control rates with acceptable toxicity[$^{10,11}$](#references). However, SBRT requires precise spatial localization of the tumour and potential metastatic lesions to plan the target area; otherwise, unexpected side effects outside the target area may occur. At present, positron emission tomography (PET) is extensively employed for monitoring the situation of tumours in clinical practice, including size, infiltration, and distant metastasis. It uses specialized radioactive glucose probes ($^{18}$F-fludeoxyglucose, $^{18}$F-FDG) or other probes to differentiate them from normal tissues, capitalizing on the characteristic high metabolic activity of tumors[$^{12}$](#references). However, after the injection of imaging agents, some patients may experience side effects such as nausea, allergies, gastrointestinal reactions, and in very rare cases, even fatalities. Additionally, conditions like inflammation and autoimmune diseases may manifest similar heightened metabolic responses to tumours, thus complicating the differential diagnosis process. The substantial costs associated with infrastructure and examination fees present yet another noteworthy hindrance to its broad adoption.
+​Excitingly, the application of neoadjuvant therapy has injected new vitality into the treatment of pancreatic cancer. Notably, stereotactic body radiation therapy (SBRT) is regarded as an emerging radiotherapy technique, capable of achieving high local control rates with acceptable toxicity[$^{10,11}$](#references). However, SBRT requires precise spatial localization of the tumour and potential metastatic lesions to plan the target area; otherwise, unexpected side effects outside the target area may occur. At present, positron emission tomography (PET) is extensively employed for monitoring the situation of tumours in clinical practice, including size, infiltration, and distant metastasis. It uses specialized radioactive glucose probes ($^{18}$F-fludeoxyglucose, $^{18}$F-FDG) or other probes to differentiate them from normal tissues, capitalizing on the characteristic high metabolic activity of tumours[$^{12}$](#references). However, after the injection of imaging agents, some patients may experience side effects such as nausea, allergies, gastrointestinal reactions, and in very rare cases, even fatalities. Additionally, conditions like inflammation and autoimmune diseases may manifest similar heightened metabolic responses to tumours, thus complicating the differential diagnosis process. The substantial costs associated with infrastructure and examination fees present yet another noteworthy hindrance to its broad adoption.
 
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@@ -52,7 +52,7 @@ Nowadays, cancer is one of the most pressing health challenges, among which panc
 
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-​On the other hand, live bacteria therapy is emerging as a promising strategy in the field of cancer treatment. Some bacteria, such as *Escherichia coli*, *Salmonella*, and *Listeria*, possess innate tumor-targeting capabilities[$^{13}$](#references). Compared with most other therapeutics, the effectiveness of tumour-targeting bacteria remains unaffected by the ‘genetic makeup’ of a tumour[$^{14}$](#references). As microscopic ‘robotic factories’, bacterial vectors can be reprogrammed to produce and deliver anticancer agents on the basis of clinical needs, serving as potent weapons for eradicating tumours. When complementing other anticancer therapies, it could achieve better clinical outcomes.
+​On the other hand, live bacteria therapy is emerging as a promising strategy in the field of cancer treatment. Some bacteria, such as *Escherichia coli*, *Salmonella*, and *Listeria*, possess innate tumour-targeting capabilities[$^{13}$](#references). Compared with most other therapeutics, the effectiveness of tumour-targeting bacteria remains unaffected by the ‘genetic makeup’ of a tumour[$^{14}$](#references). As microscopic ‘robotic factories’, bacterial vectors can be reprogrammed to produce and deliver anticancer agents on the basis of clinical needs, serving as potent weapons for eradicating tumours. When complementing other anticancer therapies, it could achieve better clinical outcomes.
 
 ​Thus, Peking 2023 is devoted to advancing bacterial therapy and introducing innovative modifications to revolutionize pancreatic cancer treatment.
 
@@ -178,4 +178,4 @@ Nowadays, cancer is one of the most pressing health challenges, among which panc
 14. Zhou, S., Gravekamp, C., Bermudes, D. & Liu, K. Tumour-targeting bacteria engineered to fight cancer. *Nat. Rev. Cancer* **18**, 727–743 (2018).
 15. Bourdeau, R. W. *et al.* Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts. *Nature* **553**, 86–90 (2018).
 16. Solé, R. & Conde-Pueyo, N. Ultrasound approach tracks gut microbes. *Nature* **553**, 36–37 (2018).
-17. Harimoto, T. *et al.* A programmable encapsulation system improves delivery of therapeutic bacteria in mice. *Nat. Biotechnol.* **40**, 1259–1269 (2022).
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+17. Harimoto, T. *et al.* A programmable encapsulation system improves delivery of therapeutic bacteria in mice. *Nat. Biotechnol.* **40**, 1259–1269 (2022).