diff --git a/static/style.css b/static/style.css
index 19617e001a75095ba2a33da32842f9a16ce2b01c..29909fe4f5b84b832cf1ad8e9f0beddaf2efa4ef 100644
--- a/static/style.css
+++ b/static/style.css
@@ -406,6 +406,229 @@ b {
color: white;
}
+/* Timeline */
+
+.timeline {
+ list-style: none;
+ padding: 10px 0;
+ position: relative;
+ font-weight: 300;
+}
+
+.timeline:before {
+ top: 0;
+ bottom: 0;
+ position: absolute;
+ content: " ";
+ width: 2px;
+ background: #ffffff;
+ left: 50%;
+ margin-left: -1.5px;
+}
+
+.timeline>li {
+ margin-bottom: 20px;
+ position: relative;
+ width: 50%;
+ float: left;
+ clear: left;
+}
+
+.timeline>li:before,
+.timeline>li:after {
+ content: " ";
+ display: table;
+}
+
+.timeline>li:after {
+ clear: both;
+}
+
+.timeline>li:before,
+.timeline>li:after {
+ content: " ";
+ display: table;
+}
+
+.timeline>li:after {
+ clear: both;
+}
+
+.timeline>li>.timeline-panel {
+ width: calc(100% - 25px);
+ width: -moz-calc(100% - 25px);
+ width: -webkit-calc(100% - 25px);
+ float: left;
+ border: 1px solid #dcdcdc;
+ background: #ffffff;
+ position: relative;
+}
+
+.timeline>li>.timeline-panel:before {
+ position: absolute;
+ top: 26px;
+ right: -15px;
+ display: inline-block;
+ border-top: 15px solid transparent;
+ border-left: 15px solid #dcdcdc;
+ border-right: 0 solid #dcdcdc;
+ border-bottom: 15px solid transparent;
+ content: " ";
+}
+
+.timeline>li>.timeline-panel:after {
+ position: absolute;
+ top: 27px;
+ right: -14px;
+ display: inline-block;
+ border-top: 14px solid transparent;
+ border-left: 14px solid #ffffff;
+ border-right: 0 solid #ffffff;
+ border-bottom: 14px solid transparent;
+ content: " ";
+}
+
+.timeline>li>.timeline-badge {
+ color: #ffffff;
+ width: 24px;
+ height: 24px;
+ line-height: 50px;
+ text-align: center;
+ position: absolute;
+ top: 16px;
+ right: -12px;
+ z-index: 100;
+}
+
+.timeline>li.timeline-inverted>.timeline-panel {
+ float: right;
+}
+
+.timeline>li.timeline-inverted>.timeline-panel:before {
+ border-left-width: 0;
+ border-right-width: 15px;
+ left: -15px;
+ right: auto;
+}
+
+.timeline>li.timeline-inverted>.timeline-panel:after {
+ border-left-width: 0;
+ border-right-width: 14px;
+ left: -14px;
+ right: auto;
+}
+
+.timeline-badge>a {
+ color: #ffffff !important;
+}
+
+.timeline-badge a:hover {
+ color: #dcdcdc !important;
+}
+
+.timeline-title {
+ margin-top: 0;
+ color: inherit;
+}
+
+.timeline-heading h4 {
+ font-weight: 400;
+ padding: 0 15px;
+ color: #4679bd;
+}
+
+.timeline-body>p,
+.timeline-body>ul {
+ padding: 10px 15px;
+ margin-bottom: 0;
+}
+
+.timeline-footer {
+ padding: 5px 15px;
+ background-color: #f4f4f4;
+}
+
+.timeline-footer p {
+ margin-bottom: 0;
+}
+
+.timeline-footer>a {
+ cursor: pointer;
+ text-decoration: none;
+}
+
+.timeline>li.timeline-inverted {
+ float: right;
+ clear: right;
+}
+
+.timeline>li:nth-child(2) {
+ margin-top: 60px;
+}
+
+.timeline>li.timeline-inverted>.timeline-badge {
+ left: -12px;
+}
+
+.no-float {
+ float: none !important;
+}
+
+@media (max-width: 767px) {
+ ul.timeline:before {
+ left: 40px;
+ }
+
+ ul.timeline>li {
+ margin-bottom: 0px;
+ position: relative;
+ width: 100%;
+ float: left;
+ clear: left;
+ }
+
+ ul.timeline>li>.timeline-panel {
+ width: calc(100% - 65px);
+ width: -moz-calc(100% - 65px);
+ width: -webkit-calc(100% - 65px);
+ }
+
+ ul.timeline>li>.timeline-badge {
+ left: 28px;
+ margin-left: 0;
+ top: 16px;
+ }
+
+ ul.timeline>li>.timeline-panel {
+ float: right;
+ }
+
+ ul.timeline>li>.timeline-panel:before {
+ border-left-width: 0;
+ border-right-width: 15px;
+ left: -15px;
+ right: auto;
+ }
+
+ ul.timeline>li>.timeline-panel:after {
+ border-left-width: 0;
+ border-right-width: 14px;
+ left: -14px;
+ right: auto;
+ }
+
+ .timeline>li.timeline-inverted {
+ float: left;
+ clear: left;
+ margin-top: 30px;
+ margin-bottom: 30px;
+ }
+
+ .timeline>li.timeline-inverted>.timeline-badge {
+ left: 28px;
+ }
+}
+
/* --------------------------------------------------------------------------- */
/* Teams page */
diff --git a/wiki/pages/human-practices.html b/wiki/pages/human-practices.html
index 57a64785b30d15d9d2333c003f6b2223dc35365c..c98153706460b3d7ef5ebf9ecacf1d15ccd1bc8a 100644
--- a/wiki/pages/human-practices.html
+++ b/wiki/pages/human-practices.html
@@ -647,59 +647,303 @@
</div>
- <div class="row">
- <img src="https://static.igem.wiki/teams/4200/wiki/human-practices/ihp-timeline.png" alt="IHP Timeline">
- </div>
+ <ul class="timeline">
+ <li data-bs-toggle="modal" data-bs-target="#ihp-modal-1">
+ <div class="timeline-badge">
+ <a><i class="fa fa-circle" id=""></i></a>
+ </div>
+ <div class="timeline-panel">
+ <div class="timeline-heading">
+ <h1>Mr. Kaushik Alike</h1>
+ </div>
+ <div class="timeline-body">
+ <p>Outreach</p>
+ </div>
+ <div class="timeline-footer">
+ <p class="text-right">November 2021</p>
+ </div>
+ </div>
+ </li>
+
+ <li class="timeline-inverted" data-bs-toggle="modal" data-bs-target="#ihp-modal-2">
+ <div class="timeline-badge">
+ <a><i class="fa fa-circle invert" id=""></i></a>
+ </div>
+ <div class="timeline-panel">
+ <div class="timeline-heading">
+ <h1>Dr. Ramesh Sistala</h1>
+ </div>
+ <div class="timeline-body">
+ <p>Company</p>
+ </div>
+ <div class="timeline-footer">
+ <p class="text-right">April 2022</p>
+ </div>
+ </div>
+ </li>
+
+ <li data-bs-toggle="modal" data-bs-target="#ihp-modal-3">
+ <div class="timeline-badge">
+ <a><i class="fa fa-circle" id=""></i></a>
+ </div>
+ <div class="timeline-panel">
+ <div class="timeline-heading">
+ <h1>Dr. Nithin M.S.</h1>
+ </div>
+ <div class="timeline-body">
+ <p>Academia</p>
+ </div>
+ <div class="timeline-footer">
+ <p class="text-right">May 2022</p>
+ </div>
+ </div>
+ </li>
+
+ <li class="timeline-inverted" data-bs-toggle="modal" data-bs-target="#ihp-modal-4">
+ <div class="timeline-badge">
+ <a><i class="fa fa-circle invert" id=""></i></a>
+ </div>
+ <div class="timeline-panel">
+ <div class="timeline-heading">
+ <h1>Mr. M Madan</h1>
+ </div>
+ <div class="timeline-body">
+ <p>Academia</p>
+ </div>
+ <div class="timeline-footer">
+ <p class="text-right">May 2022</p>
+ </div>
+ </div>
+ </li>
+
+ <li data-bs-toggle="modal" data-bs-target="#ihp-modal-5">
+ <div class="timeline-badge">
+ <a><i class="fa fa-circle" id=""></i></a>
+ </div>
+ <div class="timeline-panel">
+ <div class="timeline-heading">
+ <h1>Dr. Seetha Krishnan</h1>
+ </div>
+ <div class="timeline-body">
+ <p>Company</p>
+ </div>
+ <div class="timeline-footer">
+ <p class="text-right">May 2022</p>
+ </div>
+ </div>
+ </li>
+
+ <li class="timeline-inverted" data-bs-toggle="modal" data-bs-target="#ihp-modal-6">
+ <div class="timeline-badge">
+ <a><i class="fa fa-circle invert" id=""></i></a>
+ </div>
+ <div class="timeline-panel">
+ <div class="timeline-heading">
+ <h1>Dr. Mamatha Ballal</h1>
+ </div>
+ <div class="timeline-body">
+ <p>Doctor</p>
+ </div>
+ <div class="timeline-footer">
+ <p class="text-right">June 2022</p>
+ </div>
+ </div>
+ </li>
+
+ <li data-bs-toggle="modal" data-bs-target="#ihp-modal-7">
+ <div class="timeline-badge">
+ <a><i class="fa fa-circle" id=""></i></a>
+ </div>
+ <div class="timeline-panel">
+ <div class="timeline-heading">
+ <h1>Dr. Ramesh Sistala</h1>
+ </div>
+ <div class="timeline-body">
+ <p>Company</p>
+ </div>
+ <div class="timeline-footer">
+ <p class="text-right">June 2022</p>
+ </div>
+ </div>
+ </li>
+
+ <li class="timeline-inverted" data-bs-toggle="modal" data-bs-target="#ihp-modal-8">
+ <div class="timeline-badge">
+ <a><i class="fa fa-circle invert" id=""></i></a>
+ </div>
+ <div class="timeline-panel">
+ <div class="timeline-heading">
+ <h1>Dr. Kannan Ramaswamy</h1>
+ </div>
+ <div class="timeline-body">
+ <p>Doctor</p>
+ </div>
+ <div class="timeline-footer">
+ <p class="text-right">July 2022</p>
+ </div>
+ </div>
+ </li>
+
+ <li data-bs-toggle="modal" data-bs-target="#ihp-modal-9">
+ <div class="timeline-badge">
+ <a><i class="fa fa-circle" id=""></i></a>
+ </div>
+ <div class="timeline-panel">
+ <div class="timeline-heading">
+ <h1>Dr. M Shashi Shekar</h1>
+ </div>
+ <div class="timeline-body">
+ <p>Academia</p>
+ </div>
+ <div class="timeline-footer">
+ <p class="text-right">July 2022</p>
+ </div>
+ </div>
+ </li>
+
+ <li class="timeline-inverted" data-bs-toggle="modal" data-bs-target="#ihp-modal-10">
+ <div class="timeline-badge">
+ <a><i class="fa fa-circle invert" id=""></i></a>
+ </div>
+ <div class="timeline-panel">
+ <div class="timeline-heading">
+ <h1>ICAR-CIBA Team</h1>
+ </div>
+ <div class="timeline-body">
+ <p>Academia</p>
+ </div>
+ <div class="timeline-footer">
+ <p class="text-right">August 2022</p>
+ </div>
+ </div>
+ </li>
+
+ <li data-bs-toggle="modal" data-bs-target="#ihp-modal-11">
+ <div class="timeline-badge">
+ <a><i class="fa fa-circle" id=""></i></a>
+ </div>
+ <div class="timeline-panel">
+ <div class="timeline-heading">
+ <h1>Dr. Manickam G</h1>
+ </div>
+ <div class="timeline-body">
+ <p>Company</p>
+ </div>
+ <div class="timeline-footer">
+ <p class="text-right">August 2022</p>
+ </div>
+ </div>
+ </li>
+
+ <li class="timeline-inverted" data-bs-toggle="modal" data-bs-target="#ihp-modal-12">
+ <div class="timeline-badge">
+ <a><i class="fa fa-circle invert" id=""></i></a>
+ </div>
+ <div class="timeline-panel">
+ <div class="timeline-heading">
+ <h1>Reiss Jones</h1>
+ </div>
+ <div class="timeline-body">
+ <p>Entrepreneur</p>
+ </div>
+ <div class="timeline-footer">
+ <p class="text-right">August 2022</p>
+ </div>
+ </div>
+ </li>
+
+ <li data-bs-toggle="modal" data-bs-target="#ihp-modal-13">
+ <div class="timeline-badge">
+ <a><i class="fa fa-circle" id=""></i></a>
+ </div>
+ <div class="timeline-panel">
+ <div class="timeline-heading">
+ <h1>Ronald Kevin D’Souza</h1>
+ </div>
+ <div class="timeline-body">
+ <p>Outreach</p>
+ </div>
+ <div class="timeline-footer">
+ <p class="text-right">August 2022</p>
+ </div>
+ </div>
+ </li>
+
+ <li class="timeline-inverted" data-bs-toggle="modal" data-bs-target="#ihp-modal-14">
+ <div class="timeline-badge">
+ <a><i class="fa fa-circle invert" id=""></i></a>
+ </div>
+ <div class="timeline-panel">
+ <div class="timeline-heading">
+ <h1>Miroslav Gasparek</h1>
+ </div>
+ <div class="timeline-body">
+ <p>Entrepreneur</p>
+ </div>
+ <div class="timeline-footer">
+ <p class="text-right">September 2022</p>
+ </div>
+ </div>
+ </li>
+
+ <li data-bs-toggle="modal" data-bs-target="#ihp-modal-15">
+ <div class="timeline-badge">
+ <a><i class="fa fa-circle" id=""></i></a>
+ </div>
+ <div class="timeline-panel">
+ <div class="timeline-heading">
+ <h1>Dr. Vinod Jyothikumar</h1>
+ </div>
+ <div class="timeline-body">
+ <p>Company</p>
+ </div>
+ <div class="timeline-footer">
+ <p class="text-right">September 2022</p>
+ </div>
+ </div>
+ </li>
+
+ <li class="clearfix no-float"></li>
+ </ul>
- <br>
- <hr>
- <p class="reveal-on-scroll">Click on the tabs below for more details</p>
<!-- Person-1 -->
- <div class="row">
- <!-- Button trigger modal -->
- <button type="button" class="btn btn-primary" data-bs-toggle="modal" data-bs-target="#ihp-modal-1">
- Mr. Kaushik Alike
- </button>
-
- <!-- Modal -->
- <div class="modal fade" id="ihp-modal-1" tabindex="-1" aria-labelledby="ihp-modal-1Label" aria-hidden="true"
- style="width: 100%;">
- <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
- <div class="modal-content">
- <div class="modal-header">
- <h3 class="modal-title reveal-on-scroll" id="ihp-modal-1Label">Mr. Kaushik Alike</h3>
- <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
- </div>
- <div class="modal-body">
- <div class="row">
- <div class="col-4">
- <div class="row">
- <p class="reveal-on-scroll">Mr. Kaushik Alike, Owner of Canares Aquaculture LPP located in
- Holanagadde, Kumta, Karnataka,
- India.</p>
- </div>
- </div>
- <div class="col-8">
- <p class="reveal-on-scroll">
- <h5>THEIR INPUT</h5> We contacted Kaushik Alike on 21st November 2021. He is one of the founders
- of
- Canares Aquaculture. He spoke to us about various topics, including parasites, viruses, feed and
- water purification. He was the one who mentioned <i>V. parahaemolyticus</i> and Oxytetracycline to
- us. An important concern he brought up was the increasing threat to the microbial flora of the
- water
- bodies. He also discussed the several strategies used to distribute feed and raise fish.</p>
- <p class="reveal-on-scroll">
- <h5>OUR INFERENCE</h5>
- Through this interaction, we started looking into the <i>Vibrio</i> species and discovered their
- impact. Furthermore, we observed that the usage of antibiotics was not lost in aquaculture
- systems. Via our literature survey and speaking to Mr. Kaushik, we found that antibiotic
- resistance
- was an alarming concern that requires immediate attention. His statement was why we picked our
- problem
- statement, and it paved the way for our project’s development.
- </p>
+ <div class="modal fade" id="ihp-modal-1" tabindex="-1" aria-labelledby="ihp-modal-1Label" aria-hidden="true"
+ style="width: 100%;">
+ <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
+ <div class="modal-content">
+ <div class="modal-header">
+ <h3 class="modal-title reveal-on-scroll" id="ihp-modal-1Label">Mr. Kaushik Alike</h3>
+ <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
+ </div>
+ <div class="modal-body">
+ <div class="row">
+ <div class="col-4">
+ <div class="row">
+ <p class="reveal-on-scroll">Mr. Kaushik Alike, Owner of Canares Aquaculture LPP located in
+ Holanagadde, Kumta, Karnataka,
+ India.</p>
</div>
</div>
+ <div class="col-8">
+ <p class="reveal-on-scroll">
+ <h5>THEIR INPUT</h5> We contacted Kaushik Alike on 21st November 2021. He is one of the founders
+ of
+ Canares Aquaculture. He spoke to us about various topics, including parasites, viruses, feed and
+ water purification. He was the one who mentioned <i>V. parahaemolyticus</i> and Oxytetracycline to
+ us. An important concern he brought up was the increasing threat to the microbial flora of the
+ water
+ bodies. He also discussed the several strategies used to distribute feed and raise fish.</p>
+ <p class="reveal-on-scroll">
+ <h5>OUR INFERENCE</h5>
+ Through this interaction, we started looking into the <i>Vibrio</i> species and discovered their
+ impact. Furthermore, we observed that the usage of antibiotics was not lost in aquaculture
+ systems. Via our literature survey and speaking to Mr. Kaushik, we found that antibiotic
+ resistance
+ was an alarming concern that requires immediate attention. His statement was why we picked our
+ problem
+ statement, and it paved the way for our project’s development.
+ </p>
+ </div>
</div>
</div>
</div>
@@ -707,63 +951,55 @@
</div>
<!-- Person-2 -->
- <div class="row">
- <!-- Button trigger modal -->
- <button type="button" class="btn btn-primary" data-bs-toggle="modal" data-bs-target="#ihp-modal-2">
- Dr. Ramesh Sistala
- </button>
-
- <!-- Modal -->
- <div class="modal fade" id="ihp-modal-2" tabindex="-1" aria-labelledby="ihp-modal-2Label" aria-hidden="true"
- style="width: 100%;">
- <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
- <div class="modal-content">
- <div class="modal-header">
- <h3 class="modal-title reveal-on-scroll" id="ihp-modal-2Label">Dr. Ramesh Sistala</h3>
- <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
- </div>
- <div class="modal-body">
- <div class="row">
- <div class="col-4">
- <div class="row">
- <img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-dr-ramesh-sistala-portrait.jpg">
- <p class="reveal-on-scroll">Dr. Ramesh Sistala, Founder and Managing Director at thinkMolecular
- Technologies Pvt. Ltd.,
- Bangalore, India.</p>
- </div>
- </div>
- <div class="col-8">
- <p class="reveal-on-scroll">
- <h5>THEIR INPUT</h5> We approached Dr. Ramesh Sistala on 13th April 2022 during the initial stages
- of
- our project to receive help on the dry lab facet of our project. He gave us some ground rules for
- finding a template to use for our protein study. Initially, he recommended we use BLAST for the
- available information in databases, and find homologous protein structures. Based on his
- suggestions, we built a homology model, and utilised Alphafold for structure prediction.
- Furthermore, he suggested exploring the available peptide libraries to comprehend the protein and
- the interaction between MAM7 and Fibronectin. Finally, he asked us to make sure that the
- hypothesis
- we produce is functional by carrying out a trial run.
- <figure class="figure reveal-on-scroll">
- <img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-ramesh-sistala-april.jpeg"
- class="figure-img img-fluid rounded" alt="Interaction with Dr. Ramesh Sistala (Meeting 1)">
- <figcaption class="figure-caption text-center">
- Interaction with Dr. Ramesh Sistala (Meeting 1)
- </figcaption>
- </figure>
- <i></i>
- <p class="reveal-on-scroll">
- <h5>OUR INFERENCE</h5>
- The ideas and suggestions he provided laid the foundation for our Dry Lab work. He was crucial in
- helping us find the most appropriate template to work with. We explored the two possibilities he
- mentioned about generating our desired sequence. Otherwise, there was another possibility where we
- could find an average sequence by using Alphafold for MAM7 and then utilising it to generate the
- fibronectin structure. Based on that, we decided to run the molecular dynamics simulation (MDS) of
- MAM7, and MAM7 with fibronectin.</p>
+ <div class="modal fade" id="ihp-modal-2" tabindex="-1" aria-labelledby="ihp-modal-2Label" aria-hidden="true"
+ style="width: 100%;">
+ <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
+ <div class="modal-content">
+ <div class="modal-header">
+ <h3 class="modal-title reveal-on-scroll" id="ihp-modal-2Label">Dr. Ramesh Sistala</h3>
+ <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
+ </div>
+ <div class="modal-body">
+ <div class="row">
+ <div class="col-4">
+ <div class="row">
+ <img
+ src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-dr-ramesh-sistala-portrait.jpg">
+ <p class="reveal-on-scroll">Dr. Ramesh Sistala, Founder and Managing Director at thinkMolecular
+ Technologies Pvt. Ltd.,
+ Bangalore, India.</p>
</div>
</div>
+ <div class="col-8">
+ <p class="reveal-on-scroll">
+ <h5>THEIR INPUT</h5> We approached Dr. Ramesh Sistala on 13th April 2022 during the initial stages
+ of
+ our project to receive help on the dry lab facet of our project. He gave us some ground rules for
+ finding a template to use for our protein study. Initially, he recommended we use BLAST for the
+ available information in databases, and find homologous protein structures. Based on his
+ suggestions, we built a homology model, and utilised Alphafold for structure prediction.
+ Furthermore, he suggested exploring the available peptide libraries to comprehend the protein and
+ the interaction between MAM7 and Fibronectin. Finally, he asked us to make sure that the
+ hypothesis
+ we produce is functional by carrying out a trial run.
+ <figure class="figure reveal-on-scroll">
+ <img
+ src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-ramesh-sistala-april.jpeg"
+ class="figure-img img-fluid rounded" alt="Interaction with Dr. Ramesh Sistala (Meeting 1)">
+ <figcaption class="figure-caption text-center">
+ Interaction with Dr. Ramesh Sistala (Meeting 1)
+ </figcaption>
+ </figure>
+ <i></i>
+ <p class="reveal-on-scroll">
+ <h5>OUR INFERENCE</h5>
+ The ideas and suggestions he provided laid the foundation for our Dry Lab work. He was crucial in
+ helping us find the most appropriate template to work with. We explored the two possibilities he
+ mentioned about generating our desired sequence. Otherwise, there was another possibility where we
+ could find an average sequence by using Alphafold for MAM7 and then utilising it to generate the
+ fibronectin structure. Based on that, we decided to run the molecular dynamics simulation (MDS) of
+ MAM7, and MAM7 with fibronectin.</p>
+ </div>
</div>
</div>
</div>
@@ -771,57 +1007,49 @@
</div>
<!-- Person-3 -->
- <div class="row">
- <!-- Button trigger modal -->
- <button type="button" class="btn btn-primary" data-bs-toggle="modal" data-bs-target="#ihp-modal-3">
- Dr. Nithin M.S.
- </button>
-
- <!-- Modal -->
- <div class="modal fade" id="ihp-modal-3" tabindex="-1" aria-labelledby="ihp-modal-3Label" aria-hidden="true"
- style="width: 100%;">
- <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
- <div class="modal-content">
- <div class="modal-header">
- <h3 class="modal-title reveal-on-scroll" id="ihp-modal-3Label">Dr. Nithin M.S.</h3>
- <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
- </div>
- <div class="modal-body">
- <div class="row">
- <div class="col-4">
- <div class="row">
- <p class="reveal-on-scroll">Dr. Nitin Muliya Sankappa, Ph. D. researcher in Fisheries
- Microbiology, Department of Aquatic
- Animal Health Management at College of Fisheries, Karnataka Veterinary Animal and Fisheries
- Sciences University, Karnataka, India.</p>
- </div>
- </div>
- <div class="col-8">
- <p class="reveal-on-scroll">
- <h5>THEIR INPUT</h5> Dr. Nithin M.S. is proficient in the field of using bacteriophages to work on
- Vibriosis. We approached him on 28th May 2022 to gather data on the prevalence of vibriosis in and
- around Manipal. We explained how MAM7 is an adhesion molecule involved in the early stages of the
- infection cycle. We wanted to imply that it was the most appropriate target in order to inhibit
- adhesion and thus prevent the infection itself. During the discussion on vibriosis, he indicated
- the
- increasing demand for solutions such as AMPifin given the disease's prominence in fish. He also
- suggested ways to deliver the peptide, and recommended using bioinformatics tools to test our
- solution's efficacy.</p>
- <figure class="figure reveal-on-scroll">
- <img src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-dr-nithin-ms-may.png"
- class="figure-img img-fluid rounded" alt="Interaction with Dr. Nithin M S">
- <figcaption class="figure-caption text-center">
- Interaction with Dr. Nithin M S
- </figcaption>
- </figure>
- <p class="reveal-on-scroll">
- <h5>OUR INFERENCE</h5>
- Via this interaction, we identified the statistical significance of vibriosis and its prevalence.
- We
- understood the plausible impact that our project could have on society and the impact AMPifin—a
- sustainable solution, could have on the fisherfolk of our country.</p>
+ <div class="modal fade" id="ihp-modal-3" tabindex="-1" aria-labelledby="ihp-modal-3Label" aria-hidden="true"
+ style="width: 100%;">
+ <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
+ <div class="modal-content">
+ <div class="modal-header">
+ <h3 class="modal-title reveal-on-scroll" id="ihp-modal-3Label">Dr. Nithin M.S.</h3>
+ <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
+ </div>
+ <div class="modal-body">
+ <div class="row">
+ <div class="col-4">
+ <div class="row">
+ <p class="reveal-on-scroll">Dr. Nitin Muliya Sankappa, Ph. D. researcher in Fisheries
+ Microbiology, Department of Aquatic
+ Animal Health Management at College of Fisheries, Karnataka Veterinary Animal and Fisheries
+ Sciences University, Karnataka, India.</p>
</div>
</div>
+ <div class="col-8">
+ <p class="reveal-on-scroll">
+ <h5>THEIR INPUT</h5> Dr. Nithin M.S. is proficient in the field of using bacteriophages to work on
+ Vibriosis. We approached him on 28th May 2022 to gather data on the prevalence of vibriosis in and
+ around Manipal. We explained how MAM7 is an adhesion molecule involved in the early stages of the
+ infection cycle. We wanted to imply that it was the most appropriate target in order to inhibit
+ adhesion and thus prevent the infection itself. During the discussion on vibriosis, he indicated
+ the
+ increasing demand for solutions such as AMPifin given the disease's prominence in fish. He also
+ suggested ways to deliver the peptide, and recommended using bioinformatics tools to test our
+ solution's efficacy.</p>
+ <figure class="figure reveal-on-scroll">
+ <img src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-dr-nithin-ms-may.png"
+ class="figure-img img-fluid rounded" alt="Interaction with Dr. Nithin M S">
+ <figcaption class="figure-caption text-center">
+ Interaction with Dr. Nithin M S
+ </figcaption>
+ </figure>
+ <p class="reveal-on-scroll">
+ <h5>OUR INFERENCE</h5>
+ Via this interaction, we identified the statistical significance of vibriosis and its prevalence.
+ We
+ understood the plausible impact that our project could have on society and the impact AMPifin—a
+ sustainable solution, could have on the fisherfolk of our country.</p>
+ </div>
</div>
</div>
</div>
@@ -829,66 +1057,58 @@
</div>
<!-- Person-4 -->
- <div class="row">
- <!-- Button trigger modal -->
- <button type="button" class="btn btn-primary" data-bs-toggle="modal" data-bs-target="#ihp-modal-4">
- Mr. M Madan
- </button>
-
- <!-- Modal -->
- <div class="modal fade" id="ihp-modal-4" tabindex="-1" aria-labelledby="ihp-modal-4Label" aria-hidden="true"
- style="width: 100%;">
- <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
- <div class="modal-content">
- <div class="modal-header">
- <h3 class="modal-title reveal-on-scroll" id="ihp-modal-4Label">Mr. M Madan</h3>
- <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
- </div>
- <div class="modal-body">
- <div class="row">
- <div class="col-4">
- <div class="row">
- <img src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-mr-m-madan-portrait.jpeg">
- <p class="reveal-on-scroll">
- Mr. M Madan, Feedmill Operator at ICAR-CIBA, Chennai, India.
- </p>
- </div>
- </div>
- <div class="col-8">
- <p class="reveal-on-scroll">
- <h5>THEIR INPUT</h5> We contacted Mr. Madhan on 29th May 2022 to get data on the basic feeding and
- cultivation practices of fish. He told us that vibriosis is quite prevalent in fish breeds such as
- Mullet and Milkfish. Being well-versed with
- the different diagnostic methods used for various ecosystems such as freshwater, saline, marine,
- brackish water, etc., he mentioned the commonly utilised medicines or antibiotics, which are fed
- to
- the fish in the system. According to his experience, vibriosis is prevalent due to the changes in
- various environmental factors, weather, climatic change, and the water’s pH and contaminant
- levels,
- collectively termed as “stress-factorsâ€. He concluded that the effect of vibriosis in humans is
- dependent on each individual’s immune system and how their body reacts to it. Furthermore, he
- elaborated on the various early detection methods such as PCR, western blotting, kit-based
- methods,
- and microscopic analysis.</p>
+ <div class="modal fade" id="ihp-modal-4" tabindex="-1" aria-labelledby="ihp-modal-4Label" aria-hidden="true"
+ style="width: 100%;">
+ <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
+ <div class="modal-content">
+ <div class="modal-header">
+ <h3 class="modal-title reveal-on-scroll" id="ihp-modal-4Label">Mr. M Madan</h3>
+ <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
+ </div>
+ <div class="modal-body">
+ <div class="row">
+ <div class="col-4">
+ <div class="row">
+ <img src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-mr-m-madan-portrait.jpeg">
<p class="reveal-on-scroll">
- <h5>OUR INFERENCE</h5>
- This interaction shed light on the feeding mechanisms practised in the fish farms. The nutritional
- value of the fish can only be maintained by providing a balanced supply of the diet. Furthermore,
- in
- order to incorporate our project as a practical approach, our formula will vary for various fish
- species with
- different intake capacities. His input pushed us to study the current methods used for on-field
- fish
- testing. We found out that diseased fish are usually isolated in the fish ponds or taken to the
- labs for further testing in an artificial ecosystem. He mentioned that the usual practice of the
- local fish farmers is to subject the fishes to various antibiotics, chemicals, such as KMnO4,
- NaCl,
- and soda lime, etc to get rid of the disease in the farm. This helped us brainstorm ideas to
- spread
- awareness on the safe usage of antibiotics.
+ Mr. M Madan, Feedmill Operator at ICAR-CIBA, Chennai, India.
</p>
</div>
</div>
+ <div class="col-8">
+ <p class="reveal-on-scroll">
+ <h5>THEIR INPUT</h5> We contacted Mr. Madhan on 29th May 2022 to get data on the basic feeding and
+ cultivation practices of fish. He told us that vibriosis is quite prevalent in fish breeds such as
+ Mullet and Milkfish. Being well-versed with
+ the different diagnostic methods used for various ecosystems such as freshwater, saline, marine,
+ brackish water, etc., he mentioned the commonly utilised medicines or antibiotics, which are fed
+ to
+ the fish in the system. According to his experience, vibriosis is prevalent due to the changes in
+ various environmental factors, weather, climatic change, and the water’s pH and contaminant
+ levels,
+ collectively termed as “stress-factorsâ€. He concluded that the effect of vibriosis in humans is
+ dependent on each individual’s immune system and how their body reacts to it. Furthermore, he
+ elaborated on the various early detection methods such as PCR, western blotting, kit-based
+ methods,
+ and microscopic analysis.</p>
+ <p class="reveal-on-scroll">
+ <h5>OUR INFERENCE</h5>
+ This interaction shed light on the feeding mechanisms practised in the fish farms. The nutritional
+ value of the fish can only be maintained by providing a balanced supply of the diet. Furthermore,
+ in
+ order to incorporate our project as a practical approach, our formula will vary for various fish
+ species with
+ different intake capacities. His input pushed us to study the current methods used for on-field
+ fish
+ testing. We found out that diseased fish are usually isolated in the fish ponds or taken to the
+ labs for further testing in an artificial ecosystem. He mentioned that the usual practice of the
+ local fish farmers is to subject the fishes to various antibiotics, chemicals, such as KMnO4,
+ NaCl,
+ and soda lime, etc to get rid of the disease in the farm. This helped us brainstorm ideas to
+ spread
+ awareness on the safe usage of antibiotics.
+ </p>
+ </div>
</div>
</div>
</div>
@@ -896,73 +1116,65 @@
</div>
<!-- Person-5 -->
- <div class="row">
- <!-- Button trigger modal -->
- <button type="button" class="btn btn-primary" data-bs-toggle="modal" data-bs-target="#ihp-modal-5">
- Dr. Seetha Krishnan
- </button>
-
- <!-- Modal -->
- <div class="modal fade" id="ihp-modal-5" tabindex="-1" aria-labelledby="ihp-modal-5Label" aria-hidden="true"
- style="width: 100%;">
- <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
- <div class="modal-content">
- <div class="modal-header">
- <h3 class="modal-title reveal-on-scroll" id="ihp-modal-5Label">Dr. Seetha Krishnan</h3>
- <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
- </div>
- <div class="modal-body">
- <div class="row">
- <div class="col-4">
- <div class="row">
- <figure class="figure reveal-on-scroll">
- <img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-dr-seetha-krishnan-portrait.jpeg"
- class="figure-img img-fluid rounded" alt="Dr. Seetha Krishnan">
- <figcaption class="figure-caption text-center">
- Dr. Seetha Krishnan, Director of Discovery Biology Solutions at Aragen Life Sciences,
- Bangalore, Karnataka, India.
- </figcaption>
- </figure>
- </div>
- </div>
- <div class="col-8">
- <p class="reveal-on-scroll">
- <h5>THEIR INPUT</h5> We interacted with Dr. Seetha Krishnan on 30th May 2022. She was intrigued by
- our
- project idea and its potential impact on the pisciculture industry. Based on the stability of our
- peptide when released into a pisciculture system, she highlighted the possibilities of our peptide
- undergoing degradation and high dilution. She spoke about lab-scale testing of our peptide for
- interaction studies. To overcome such challenges, she suggested we look into methods like
- encapsulation and check the integrity properties in accordance with the release of the peptide
- into
- the aquaculture set-up. She also told us to look into our solution's economic viability, upscaling
- its production and food safety factors. Additionally, she conveyed her concerns regarding the
- peptide purification
- aspects of our project. She recommended we use the HPLC system for regular purification, which
- would
- be a practical approach for our experiments due to its cost-effectiveness.</p>
+ <div class="modal fade" id="ihp-modal-5" tabindex="-1" aria-labelledby="ihp-modal-5Label" aria-hidden="true"
+ style="width: 100%;">
+ <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
+ <div class="modal-content">
+ <div class="modal-header">
+ <h3 class="modal-title reveal-on-scroll" id="ihp-modal-5Label">Dr. Seetha Krishnan</h3>
+ <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
+ </div>
+ <div class="modal-body">
+ <div class="row">
+ <div class="col-4">
+ <div class="row">
<figure class="figure reveal-on-scroll">
<img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-dr-seetha-krishnan-may.png"
- class="figure-img img-fluid rounded" alt="Interaction with Dr. Seetha Krishnan">
+ src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-dr-seetha-krishnan-portrait.jpeg"
+ class="figure-img img-fluid rounded" alt="Dr. Seetha Krishnan">
<figcaption class="figure-caption text-center">
- Interaction with Dr. Seetha Krishnan
+ Dr. Seetha Krishnan, Director of Discovery Biology Solutions at Aragen Life Sciences,
+ Bangalore, Karnataka, India.
</figcaption>
</figure>
- <p class="reveal-on-scroll">
- <h5>OUR INFERENCE</h5>
- Dr. Seetha laid the foundation for our delivery system. Our interaction with her made us consider
- the factors involving the cost-effectiveness of our solution. Through this, we decided
- <i>Escherichia coli</i> was the best host for our peptide production. She helped us look into our
- idea's biosafety and bioethical concerns. Her recommendations also made us look at CRISPR-based
- systems for plasmid designing. The papers she sent helped us with inputs to design our delivery
- mechanism—i.e. chitosan nanoparticle encapsulation. Towards the end of the meeting,
- we accounted for her varied insights on the ethical issues revolving around our project. This made
- us analyse and work on an effective approach for the society and the environment.
- </p>
</div>
</div>
+ <div class="col-8">
+ <p class="reveal-on-scroll">
+ <h5>THEIR INPUT</h5> We interacted with Dr. Seetha Krishnan on 30th May 2022. She was intrigued by
+ our
+ project idea and its potential impact on the pisciculture industry. Based on the stability of our
+ peptide when released into a pisciculture system, she highlighted the possibilities of our peptide
+ undergoing degradation and high dilution. She spoke about lab-scale testing of our peptide for
+ interaction studies. To overcome such challenges, she suggested we look into methods like
+ encapsulation and check the integrity properties in accordance with the release of the peptide
+ into
+ the aquaculture set-up. She also told us to look into our solution's economic viability, upscaling
+ its production and food safety factors. Additionally, she conveyed her concerns regarding the
+ peptide purification
+ aspects of our project. She recommended we use the HPLC system for regular purification, which
+ would
+ be a practical approach for our experiments due to its cost-effectiveness.</p>
+ <figure class="figure reveal-on-scroll">
+ <img
+ src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-dr-seetha-krishnan-may.png"
+ class="figure-img img-fluid rounded" alt="Interaction with Dr. Seetha Krishnan">
+ <figcaption class="figure-caption text-center">
+ Interaction with Dr. Seetha Krishnan
+ </figcaption>
+ </figure>
+ <p class="reveal-on-scroll">
+ <h5>OUR INFERENCE</h5>
+ Dr. Seetha laid the foundation for our delivery system. Our interaction with her made us consider
+ the factors involving the cost-effectiveness of our solution. Through this, we decided
+ <i>Escherichia coli</i> was the best host for our peptide production. She helped us look into our
+ idea's biosafety and bioethical concerns. Her recommendations also made us look at CRISPR-based
+ systems for plasmid designing. The papers she sent helped us with inputs to design our delivery
+ mechanism—i.e. chitosan nanoparticle encapsulation. Towards the end of the meeting,
+ we accounted for her varied insights on the ethical issues revolving around our project. This made
+ us analyse and work on an effective approach for the society and the environment.
+ </p>
+ </div>
</div>
</div>
</div>
@@ -970,80 +1182,72 @@
</div>
<!-- Person-6 -->
- <div class="row">
- <!-- Button trigger modal -->
- <button type="button" class="btn btn-primary" data-bs-toggle="modal" data-bs-target="#ihp-modal-6">
- Dr. Mamatha Ballal
- </button>
-
- <!-- Modal -->
- <div class="modal fade" id="ihp-modal-6" tabindex="-1" aria-labelledby="ihp-modal-6Label" aria-hidden="true"
- style="width: 100%;">
- <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
- <div class="modal-content">
- <div class="modal-header">
- <h3 class="modal-title reveal-on-scroll" id="ihp-modal-6Label">Dr. Mamatha Ballal</h3>
- <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
- </div>
- <div class="modal-body">
- <div class="row">
- <div class="col-4">
- <div class="row">
- <figure class="figure reveal-on-scroll">
- <img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-dr-mamatha-ballal-portrait.jpeg"
- class="figure-img img-fluid rounded" alt="Dr. Mamatha Ballal">
- <figcaption class="figure-caption text-center">
- Dr. Mamatha Ballal, Professor in the Department of Microbiology at Enteric Diseases
- Division—Head, Kasturba Medical College, Manipal, Karnataka, India.
- </figcaption>
- </figure>
- </div>
- </div>
- <div class="col-8">
- <p class="reveal-on-scroll">
- <h5>THEIR INPUT</h5>We approached Dr. Mamatha Ballal on 2nd June 2022 to get solutions for our
- research-based queries and information on the prevalence of vibriosis. Since vibriosis is a cause
- of
- concern in humans as well, her expertise area made her the most appropriate person
- to reach out to. We learnt the symptoms and treatment methods of vibriosis in humans.
- Additionally,
- we gained more information on the pathogenicity and virulence of <i>V.
- parahaemolyticus</i>. Commenting on the frequency of people suffering from vibriosis in our
- locality, she mentioned that <i>V. parahaemolyticus</i> is pervasive in people who consume
- non-vegetarian food. According to her, the severity of the infection is majorly caused
- due to poor sanitation and hygiene habits followed. Though vibriosis is a devastating disease, it
- is
- most commonly prevalent in rural areas as compared to urban areas. She mentioned that people
- suffering from vibriosis usually suffer from diarrhoea which leads to higher chances of mortality,
- especially among immunocompromised people. She gave her suggestions for reducing the risks
- associated
- with <i>Vibrio</i> spp. and also said that <i>V. parahaemolyticus</i> is a common food pathogen.
- She
- mentioned how temperature change could also affect the pathogenicity factors of vibriosis. She
- also
- mentioned that stool samples are collected to analyse and detect vibriosis in humans. Furthermore,
- she elaborated on the culture-based methods for <i>V. parahaemolyticus</i>—i.e., using blood agar
- and nutrient agar.</p>
+ <div class="modal fade" id="ihp-modal-6" tabindex="-1" aria-labelledby="ihp-modal-6Label" aria-hidden="true"
+ style="width: 100%;">
+ <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
+ <div class="modal-content">
+ <div class="modal-header">
+ <h3 class="modal-title reveal-on-scroll" id="ihp-modal-6Label">Dr. Mamatha Ballal</h3>
+ <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
+ </div>
+ <div class="modal-body">
+ <div class="row">
+ <div class="col-4">
+ <div class="row">
<figure class="figure reveal-on-scroll">
<img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-dr-mamatha-ballal-june.jpg"
- class="figure-img img-fluid rounded" alt="Interaction with Dr. Mamatha Ballal">
+ src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-dr-mamatha-ballal-portrait.jpeg"
+ class="figure-img img-fluid rounded" alt="Dr. Mamatha Ballal">
<figcaption class="figure-caption text-center">
- Interaction with Dr. Mamatha Ballal
+ Dr. Mamatha Ballal, Professor in the Department of Microbiology at Enteric Diseases
+ Division—Head, Kasturba Medical College, Manipal, Karnataka, India.
</figcaption>
</figure>
- <p class="reveal-on-scroll">
- <h5>OUR INFERENCE</h5>
- The interaction with Dr. Ballal helped us gain more statistical data on the reported cases
- concerning vibriosis. This helped us build a core understanding of the importance of following
- good
- hygiene practices by taking small steps to avoid such diseases. We also learnt about the various
- detection methods used. She also demonstrated lab techniques that could benefit our
- future implementation studies.
- </p>
</div>
</div>
+ <div class="col-8">
+ <p class="reveal-on-scroll">
+ <h5>THEIR INPUT</h5>We approached Dr. Mamatha Ballal on 2nd June 2022 to get solutions for our
+ research-based queries and information on the prevalence of vibriosis. Since vibriosis is a cause
+ of
+ concern in humans as well, her expertise area made her the most appropriate person
+ to reach out to. We learnt the symptoms and treatment methods of vibriosis in humans.
+ Additionally,
+ we gained more information on the pathogenicity and virulence of <i>V.
+ parahaemolyticus</i>. Commenting on the frequency of people suffering from vibriosis in our
+ locality, she mentioned that <i>V. parahaemolyticus</i> is pervasive in people who consume
+ non-vegetarian food. According to her, the severity of the infection is majorly caused
+ due to poor sanitation and hygiene habits followed. Though vibriosis is a devastating disease, it
+ is
+ most commonly prevalent in rural areas as compared to urban areas. She mentioned that people
+ suffering from vibriosis usually suffer from diarrhoea which leads to higher chances of mortality,
+ especially among immunocompromised people. She gave her suggestions for reducing the risks
+ associated
+ with <i>Vibrio</i> spp. and also said that <i>V. parahaemolyticus</i> is a common food pathogen.
+ She
+ mentioned how temperature change could also affect the pathogenicity factors of vibriosis. She
+ also
+ mentioned that stool samples are collected to analyse and detect vibriosis in humans. Furthermore,
+ she elaborated on the culture-based methods for <i>V. parahaemolyticus</i>—i.e., using blood agar
+ and nutrient agar.</p>
+ <figure class="figure reveal-on-scroll">
+ <img
+ src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-dr-mamatha-ballal-june.jpg"
+ class="figure-img img-fluid rounded" alt="Interaction with Dr. Mamatha Ballal">
+ <figcaption class="figure-caption text-center">
+ Interaction with Dr. Mamatha Ballal
+ </figcaption>
+ </figure>
+ <p class="reveal-on-scroll">
+ <h5>OUR INFERENCE</h5>
+ The interaction with Dr. Ballal helped us gain more statistical data on the reported cases
+ concerning vibriosis. This helped us build a core understanding of the importance of following
+ good
+ hygiene practices by taking small steps to avoid such diseases. We also learnt about the various
+ detection methods used. She also demonstrated lab techniques that could benefit our
+ future implementation studies.
+ </p>
+ </div>
</div>
</div>
</div>
@@ -1051,73 +1255,65 @@
</div>
<!-- Person-7 -->
- <div class="row">
- <!-- Button trigger modal -->
- <button type="button" class="btn btn-primary" data-bs-toggle="modal" data-bs-target="#ihp-modal-7">
- Dr. Ramesh Sistala (Meeting 2)
- </button>
-
- <!-- Modal -->
- <div class="modal fade" id="ihp-modal-7" tabindex="-1" aria-labelledby="ihp-modal-7Label" aria-hidden="true"
- style="width: 100%;">
- <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
- <div class="modal-content">
- <div class="modal-header">
- <h3 class="modal-title reveal-on-scroll" id="ihp-modal-7Label">Dr. Ramesh Sistala</h3>
- <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
- </div>
- <div class="modal-body">
- <div class="row">
- <div class="col-4">
- <div class="row">
- <figure class="figure reveal-on-scroll">
- <img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-dr-ramesh-sistala-portrait.jpg"
- class="figure-img img-fluid rounded" alt="Dr. Ramesh Sistala">
- <figcaption class="figure-caption text-center">
- Dr. Ramesh Sistala, Founder and Managing Director at thinkMolecular Technologies Pvt. Ltd.,
- Bangalore, India.
- </figcaption>
- </figure>
- </div>
- </div>
- <div class="col-8">
- <p class="reveal-on-scroll">
- <h5>THEIR INPUT</h5> We had our second interaction with Dr. Ramesh on 28th June 2022 to discuss
- the
- structure
- prediction of MAM7. We explained the adhesion mechanism and how we used ClusPro for docking. To
- design our peptide at this stage, we tried to integrate the concept of peptidomimetics. He
- mentioned that fibronectin is the apparent binding site with five repeating units, and the
- repeating
- modules are used for the initial peptide design. Dr. Ramesh suggested that we could use a
- computational alanine scan to refine the binding sites and molecular dynamic simulations. If the
- receptor is prominent, we cannot do it on the 40 amino acids and would have find the local binding
- regions. To inhibit the reaction, the five continuous domains of MAM7 are required to interact. In
- this case, the peptide acts as an inhibitor, and the peptide docking is done on the receptor. If
- the
- receptor is big, a hypothesis should be formulated that interacts with MAM7. The model can be
- verified by profiling the interaction. The relevant residues can be docked by using only specific
- residues and changing the others. Furthermore, he elaborated that five or six types of amino acids
- are required, and all 20 amino acids need not be required. He further elaborated more on the Build
- option in Pymol that could be used for visualising the protein structure.</p>
+ <div class="modal fade" id="ihp-modal-7" tabindex="-1" aria-labelledby="ihp-modal-7Label" aria-hidden="true"
+ style="width: 100%;">
+ <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
+ <div class="modal-content">
+ <div class="modal-header">
+ <h3 class="modal-title reveal-on-scroll" id="ihp-modal-7Label">Dr. Ramesh Sistala</h3>
+ <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
+ </div>
+ <div class="modal-body">
+ <div class="row">
+ <div class="col-4">
+ <div class="row">
<figure class="figure reveal-on-scroll">
<img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-dr-ramesh-sistala-2-0-june.png"
- class="figure-img img-fluid rounded" alt="Interaction with Dr. Ramesh Sistala">
+ src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-dr-ramesh-sistala-portrait.jpg"
+ class="figure-img img-fluid rounded" alt="Dr. Ramesh Sistala">
<figcaption class="figure-caption text-center">
- Interaction with Dr. Ramesh Sistala
+ Dr. Ramesh Sistala, Founder and Managing Director at thinkMolecular Technologies Pvt. Ltd.,
+ Bangalore, India.
</figcaption>
</figure>
- <p class="reveal-on-scroll">
- <h5>OUR INFERENCE</h5>
- In this meeting, Dr. Ramesh provided us with the technique to generate a pool of peptides. This is
- where we decided our peptide to act as an inhibitor for our target molecule—MAM7. Furthermore, the
- alanine scan test he suggested was the basis for our modification cycles, including our software
- contribution.
- </p>
</div>
</div>
+ <div class="col-8">
+ <p class="reveal-on-scroll">
+ <h5>THEIR INPUT</h5> We had our second interaction with Dr. Ramesh on 28th June 2022 to discuss
+ the
+ structure
+ prediction of MAM7. We explained the adhesion mechanism and how we used ClusPro for docking. To
+ design our peptide at this stage, we tried to integrate the concept of peptidomimetics. He
+ mentioned that fibronectin is the apparent binding site with five repeating units, and the
+ repeating
+ modules are used for the initial peptide design. Dr. Ramesh suggested that we could use a
+ computational alanine scan to refine the binding sites and molecular dynamic simulations. If the
+ receptor is prominent, we cannot do it on the 40 amino acids and would have find the local binding
+ regions. To inhibit the reaction, the five continuous domains of MAM7 are required to interact. In
+ this case, the peptide acts as an inhibitor, and the peptide docking is done on the receptor. If
+ the
+ receptor is big, a hypothesis should be formulated that interacts with MAM7. The model can be
+ verified by profiling the interaction. The relevant residues can be docked by using only specific
+ residues and changing the others. Furthermore, he elaborated that five or six types of amino acids
+ are required, and all 20 amino acids need not be required. He further elaborated more on the Build
+ option in Pymol that could be used for visualising the protein structure.</p>
+ <figure class="figure reveal-on-scroll">
+ <img
+ src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-dr-ramesh-sistala-2-0-june.png"
+ class="figure-img img-fluid rounded" alt="Interaction with Dr. Ramesh Sistala">
+ <figcaption class="figure-caption text-center">
+ Interaction with Dr. Ramesh Sistala
+ </figcaption>
+ </figure>
+ <p class="reveal-on-scroll">
+ <h5>OUR INFERENCE</h5>
+ In this meeting, Dr. Ramesh provided us with the technique to generate a pool of peptides. This is
+ where we decided our peptide to act as an inhibitor for our target molecule—MAM7. Furthermore, the
+ alanine scan test he suggested was the basis for our modification cycles, including our software
+ contribution.
+ </p>
+ </div>
</div>
</div>
</div>
@@ -1125,72 +1321,64 @@
</div>
<!-- Person-8 -->
- <div class="row">
- <!-- Button trigger modal -->
- <button type="button" class="btn btn-primary" data-bs-toggle="modal" data-bs-target="#ihp-modal-8">
- Dr. Kannan Ramaswamy
- </button>
-
- <!-- Modal -->
- <div class="modal fade" id="ihp-modal-8" tabindex="-1" aria-labelledby="ihp-modal-8Label" aria-hidden="true"
- style="width: 100%;">
- <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
- <div class="modal-content">
- <div class="modal-header">
- <h3 class="modal-title reveal-on-scroll" id="ihp-modal-8Label">Dr. Kannan Ramaswamy</h3>
- <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
- </div>
- <div class="modal-body">
- <div class="row">
- <div class="col-4">
- <div class="row">
- <p class="reveal-on-scroll">Dr. Kannan Ramaswamy is a Gastroenterologist at Bhagwan Mahaveer Jain
- Hospital, Bangalore,
- and
- Sagar Hospitals in Jayanagar, Bangalore. He is a member of the Indian Medical Association
- (IMA)
- and Karnataka Medical Council.
- </p>
- </div>
- </div>
- <div class="col-8">
- <p class="reveal-on-scroll">
- <h5>THEIR INPUT</h5> We approached Dr. Kannan on 3rd July 2022 to get information on the effect of
- vibriosis on human beings. Based on his research, he indicated that vibriosis involves a sporadic
- outbreak that is not as prevalent in urban areas since they consume filtered water. With many
- years
- of experience, he mentioned that an epidemic is more noticeable around river bed regions due to
- direct river water consumption and spreads as a communicable disease.
- The severity of these infections is often treatable by following the appropriate hydration
- measures
- as the patients are observed for an incubation period of three days for the development of any
- symptoms like vomiting, loose motions, or rice water diarrhoea. According to him, the major source
- of vibriosis infection in humans is untreated water. Furthermore, he mentioned that vaccines are
- administered to reduce a local epidemic risk. However, he also mentioned that often, vaccines
- don't
- find their way to rural areas, leading to large-scale epidemics that could be lethal beyond a
- point.
- </p>
- <figure class="figure reveal-on-scroll">
- <img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-dr-kannan-ramaswamy-july.jpg"
- class="figure-img img-fluid rounded" alt="Interaction with Dr. Kannan Ramaswamy">
- <figcaption class="figure-caption text-center">
- Interaction with Dr. Kannan Ramaswamy
- </figcaption>
- </figure>
- <p class="reveal-on-scroll">
- <h5>OUR INFERENCE</h5>
- The interaction with Dr. Kannan gave us an insight into statistics associated with reported cases
- of
- vibriosis in India and worldwide. This made us consider the ethical aspects concerning AMPifin and
- the treatment plans followed when such cases are reported. We could also gauge the vicious cycle
- of
- administration of antibiotics that could be harmful to an individual or be redundant for the
- <i>Vibrio</i> species due to the development of antibiotic resistance.
+ <div class="modal fade" id="ihp-modal-8" tabindex="-1" aria-labelledby="ihp-modal-8Label" aria-hidden="true"
+ style="width: 100%;">
+ <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
+ <div class="modal-content">
+ <div class="modal-header">
+ <h3 class="modal-title reveal-on-scroll" id="ihp-modal-8Label">Dr. Kannan Ramaswamy</h3>
+ <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
+ </div>
+ <div class="modal-body">
+ <div class="row">
+ <div class="col-4">
+ <div class="row">
+ <p class="reveal-on-scroll">Dr. Kannan Ramaswamy is a Gastroenterologist at Bhagwan Mahaveer Jain
+ Hospital, Bangalore,
+ and
+ Sagar Hospitals in Jayanagar, Bangalore. He is a member of the Indian Medical Association
+ (IMA)
+ and Karnataka Medical Council.
</p>
</div>
</div>
+ <div class="col-8">
+ <p class="reveal-on-scroll">
+ <h5>THEIR INPUT</h5> We approached Dr. Kannan on 3rd July 2022 to get information on the effect of
+ vibriosis on human beings. Based on his research, he indicated that vibriosis involves a sporadic
+ outbreak that is not as prevalent in urban areas since they consume filtered water. With many
+ years
+ of experience, he mentioned that an epidemic is more noticeable around river bed regions due to
+ direct river water consumption and spreads as a communicable disease.
+ The severity of these infections is often treatable by following the appropriate hydration
+ measures
+ as the patients are observed for an incubation period of three days for the development of any
+ symptoms like vomiting, loose motions, or rice water diarrhoea. According to him, the major source
+ of vibriosis infection in humans is untreated water. Furthermore, he mentioned that vaccines are
+ administered to reduce a local epidemic risk. However, he also mentioned that often, vaccines
+ don't
+ find their way to rural areas, leading to large-scale epidemics that could be lethal beyond a
+ point.
+ </p>
+ <figure class="figure reveal-on-scroll">
+ <img
+ src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-dr-kannan-ramaswamy-july.jpg"
+ class="figure-img img-fluid rounded" alt="Interaction with Dr. Kannan Ramaswamy">
+ <figcaption class="figure-caption text-center">
+ Interaction with Dr. Kannan Ramaswamy
+ </figcaption>
+ </figure>
+ <p class="reveal-on-scroll">
+ <h5>OUR INFERENCE</h5>
+ The interaction with Dr. Kannan gave us an insight into statistics associated with reported cases
+ of
+ vibriosis in India and worldwide. This made us consider the ethical aspects concerning AMPifin and
+ the treatment plans followed when such cases are reported. We could also gauge the vicious cycle
+ of
+ administration of antibiotics that could be harmful to an individual or be redundant for the
+ <i>Vibrio</i> species due to the development of antibiotic resistance.
+ </p>
+ </div>
</div>
</div>
</div>
@@ -1198,64 +1386,56 @@
</div>
<!-- Person-9 -->
- <div class="row">
- <!-- Button trigger modal -->
- <button type="button" class="btn btn-primary" data-bs-toggle="modal" data-bs-target="#ihp-modal-9">
- Dr. M Shashi Shekar
- </button>
-
- <!-- Modal -->
- <div class="modal fade" id="ihp-modal-9" tabindex="-1" aria-labelledby="ihp-modal-9Label" aria-hidden="true"
- style="width: 100%;">
- <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
- <div class="modal-content">
- <div class="modal-header">
- <h3 class="modal-title reveal-on-scroll" id="ihp-modal-9Label">Dr. M Shashi Shekar</h3>
- <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
- </div>
- <div class="modal-body">
- <div class="row">
- <div class="col-4">
- <div class="row">
- <p class="reveal-on-scroll">Dr. M. Shashi Shekar, Principal Scientist & SIC, Nutrition, Genetics
- and Biotechnology
- Division, working since 1994 in ICAR-CIBA, Chennai, India.
- </p>
- </div>
- </div>
- <div class="col-8">
- <p class="reveal-on-scroll">
- <h5>THEIR INPUT</h5>We visited the Indian Council of Agricultural Research-Central Institute of
- Brackishwater Research (ICAR- CIBA) institute located in Chennai on 8th July 2022. Dr. M Shashi
- Shekar
- and his team consisting of Dr. Ashok, Dr. Raymond, Dr. Sujeet and Dr. Patil who were working on
- the
- prevalence of vibriosis in fish. We felt that the information they had would benefit our project’s
- geographical statistics and research-related data. There was a brief discussion about the types of
- projects they were working on for the research-oriented communities and looking for potential
- areas
- in which they could assist us with. Dr. Shashi Shekar introduced us to his lab and his team which
- would help us in the future with our project.</p>
- <figure class="figure reveal-on-scroll">
- <img src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-icar-ciba-july.jpg"
- class="figure-img img-fluid rounded" alt="Interaction with Dr. M Shashi Shekar">
- <figcaption class="figure-caption text-center">
- Interaction with Dr. M Shashi Shekar
- </figcaption>
- </figure>
- <p class="reveal-on-scroll">
- <h5>OUR INFERENCE</h5>
- The visit to their institute assisted us in gathering more information on the field studies of
- their
- testing is carried out, which are similar to our project. We utilised this to bring out the
- efficacy
- of our peptide and the disease. Furthermore, they also gave data on the products they manufactured
- and their current ongoing research. They also provided specific lab protocols that were useful for
- our future implementation. After this meeting, we decided to have another meeting with them to
- further exchange data on the research carried out.
+ <div class="modal fade" id="ihp-modal-9" tabindex="-1" aria-labelledby="ihp-modal-9Label" aria-hidden="true"
+ style="width: 100%;">
+ <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
+ <div class="modal-content">
+ <div class="modal-header">
+ <h3 class="modal-title reveal-on-scroll" id="ihp-modal-9Label">Dr. M Shashi Shekar</h3>
+ <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
+ </div>
+ <div class="modal-body">
+ <div class="row">
+ <div class="col-4">
+ <div class="row">
+ <p class="reveal-on-scroll">Dr. M. Shashi Shekar, Principal Scientist & SIC, Nutrition, Genetics
+ and Biotechnology
+ Division, working since 1994 in ICAR-CIBA, Chennai, India.
</p>
</div>
</div>
+ <div class="col-8">
+ <p class="reveal-on-scroll">
+ <h5>THEIR INPUT</h5>We visited the Indian Council of Agricultural Research-Central Institute of
+ Brackishwater Research (ICAR- CIBA) institute located in Chennai on 8th July 2022. Dr. M Shashi
+ Shekar
+ and his team consisting of Dr. Ashok, Dr. Raymond, Dr. Sujeet and Dr. Patil who were working on
+ the
+ prevalence of vibriosis in fish. We felt that the information they had would benefit our project’s
+ geographical statistics and research-related data. There was a brief discussion about the types of
+ projects they were working on for the research-oriented communities and looking for potential
+ areas
+ in which they could assist us with. Dr. Shashi Shekar introduced us to his lab and his team which
+ would help us in the future with our project.</p>
+ <figure class="figure reveal-on-scroll">
+ <img src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-icar-ciba-july.jpg"
+ class="figure-img img-fluid rounded" alt="Interaction with Dr. M Shashi Shekar">
+ <figcaption class="figure-caption text-center">
+ Interaction with Dr. M Shashi Shekar
+ </figcaption>
+ </figure>
+ <p class="reveal-on-scroll">
+ <h5>OUR INFERENCE</h5>
+ The visit to their institute assisted us in gathering more information on the field studies of
+ their
+ testing is carried out, which are similar to our project. We utilised this to bring out the
+ efficacy
+ of our peptide and the disease. Furthermore, they also gave data on the products they manufactured
+ and their current ongoing research. They also provided specific lab protocols that were useful for
+ our future implementation. After this meeting, we decided to have another meeting with them to
+ further exchange data on the research carried out.
+ </p>
+ </div>
</div>
</div>
</div>
@@ -1263,62 +1443,54 @@
</div>
<!-- Person-10 -->
- <div class="row">
- <!-- Button trigger modal -->
- <button type="button" class="btn btn-primary" data-bs-toggle="modal" data-bs-target="#ihp-modal-10">
- ICAR-CIBA
- </button>
-
- <!-- Modal -->
- <div class="modal fade" id="ihp-modal-10" tabindex="-1" aria-labelledby="ihp-modal-10Label" aria-hidden="true"
- style="width: 100%;">
- <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
- <div class="modal-content">
- <div class="modal-header">
- <h3 class="modal-title reveal-on-scroll" id="ihp-modal-10Label">ICAR-CIBA</h3>
- <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
- </div>
- <div class="modal-body">
- <div class="row">
- <div class="col-4">
- <div class="row">
- <p class="reveal-on-scroll">ICAR-CIBA (Dr. M Shashi Shekar & team), Chennai, India.
- </p>
- </div>
- </div>
- <div class="col-8">
- <p class="reveal-on-scroll">
- <h5>THEIR INPUT</h5> We approached Dr. Shashi Shekhar and his team from ICAR-CIBA on 10th August
- 2022
- after meeting them at their institute. He introduced us to Dr. Ashok, well-versed in
- bioinformatics,
- who discussed our dry lab aspects. Dr. Raymond, who holds good knowledge of aquaculture
- operations,
- helped us gather the parameters necessary for the fish tank dimensions. Likewise, Dr. Patil and
- Dr.
- Sujeet were the two microbiologists who helped us collect data for our research. They provided
- relevant data about the various bacteria present in <i>Vibrio</i> species that affect fish and
- shrimps. We further interacted with them about the various other bacterial and viral diseases that
- cause economic losses to the fisherfolk. They provided more data on parameters, such as pH value
- range and ammonia concentration that are to be maintained to prevent such outbreaks of diseases in
- the fish farm. Furthermore, they appreciated our idea of targeting initial adhesion and discussed
- current treatment methods.</p>
- <figure class="figure reveal-on-scroll">
- <img src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-icar-ciba-august.jpg"
- class="figure-img img-fluid rounded" alt="Interaction with ICAR-CIBA">
- <figcaption class="figure-caption text-center">
- Interaction with ICAR-CIBA
- </figcaption>
- </figure>
- <p class="reveal-on-scroll">
- <h5>OUR INFERENCE</h5>
- It was due to Dr. Raymond that we could formulate a design system for our mesh that would fit at
- the
- inlet pipe. His input on the numbers corresponding to the tank and pipe dimensions helped us get a
- clear idea of our design.
+ <div class="modal fade" id="ihp-modal-10" tabindex="-1" aria-labelledby="ihp-modal-10Label" aria-hidden="true"
+ style="width: 100%;">
+ <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
+ <div class="modal-content">
+ <div class="modal-header">
+ <h3 class="modal-title reveal-on-scroll" id="ihp-modal-10Label">ICAR-CIBA</h3>
+ <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
+ </div>
+ <div class="modal-body">
+ <div class="row">
+ <div class="col-4">
+ <div class="row">
+ <p class="reveal-on-scroll">ICAR-CIBA (Dr. M Shashi Shekar & team), Chennai, India.
</p>
</div>
</div>
+ <div class="col-8">
+ <p class="reveal-on-scroll">
+ <h5>THEIR INPUT</h5> We approached Dr. Shashi Shekhar and his team from ICAR-CIBA on 10th August
+ 2022
+ after meeting them at their institute. He introduced us to Dr. Ashok, well-versed in
+ bioinformatics,
+ who discussed our dry lab aspects. Dr. Raymond, who holds good knowledge of aquaculture
+ operations,
+ helped us gather the parameters necessary for the fish tank dimensions. Likewise, Dr. Patil and
+ Dr.
+ Sujeet were the two microbiologists who helped us collect data for our research. They provided
+ relevant data about the various bacteria present in <i>Vibrio</i> species that affect fish and
+ shrimps. We further interacted with them about the various other bacterial and viral diseases that
+ cause economic losses to the fisherfolk. They provided more data on parameters, such as pH value
+ range and ammonia concentration that are to be maintained to prevent such outbreaks of diseases in
+ the fish farm. Furthermore, they appreciated our idea of targeting initial adhesion and discussed
+ current treatment methods.</p>
+ <figure class="figure reveal-on-scroll">
+ <img src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-icar-ciba-august.jpg"
+ class="figure-img img-fluid rounded" alt="Interaction with ICAR-CIBA">
+ <figcaption class="figure-caption text-center">
+ Interaction with ICAR-CIBA
+ </figcaption>
+ </figure>
+ <p class="reveal-on-scroll">
+ <h5>OUR INFERENCE</h5>
+ It was due to Dr. Raymond that we could formulate a design system for our mesh that would fit at
+ the
+ inlet pipe. His input on the numbers corresponding to the tank and pipe dimensions helped us get a
+ clear idea of our design.
+ </p>
+ </div>
</div>
</div>
</div>
@@ -1326,75 +1498,65 @@
</div>
<!-- Person-11 -->
- <div class="row">
- <!-- Button trigger modal -->
- <button type="button" class="btn btn-primary" data-bs-toggle="modal" data-bs-target="#ihp-modal-11">
- Dr. Manickam G
- </button>
-
- <!-- Modal -->
- <div class="modal fade" id="ihp-modal-11" tabindex="-1" aria-labelledby="ihp-modal-11Label" aria-hidden="true"
- style="width: 100%;">
- <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
- <div class="modal-content">
- <div class="modal-header">
- <h3 class="modal-title reveal-on-scroll" id="ihp-modal-11Label">Dr. Manickam G</h3>
- <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
- </div>
- <div class="modal-body">
- <div class="row">
- <div class="col-4">
- <div class="row">
- <figure class="figure reveal-on-scroll">
- <img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-dr-manickam-g-portrait.jpeg"
- class="figure-img img-fluid rounded"
- alt="Dr. Manickam, Research Director, Discovery Chemistry, Bangalore, India.">
- <figcaption class="figure-caption text-center">
- Dr. Manickam, Research Director, Discovery Chemistry, Bangalore, India.
- </figcaption>
- </figure>
- </div>
- </div>
- <div class="col-8">
- <p class="reveal-on-scroll">
- <h5>THEIR INPUT</h5> We interacted with Dr. Manickam on 12th August 2022, to receive inputs on the
- economic viability and large-scale production of our peptide. He was impressed with our usage of
- chitosan nanoparticles as a delivery system since it is a natural polymer with immunomodulatory
- properties and is biodegradable, too. He suggested that we increment the length of our peptide
- that
- would help boost our large-scale production. Through this, the purification cost would decrease
- and
- the ideal stability conditions and formulation required for the same would be at a more convenient
- level. This drastically decreases the volume, making our solution more convenient for biological
- maintenance. He mentioned that the current methods include the biological-based drugs and proteins
- that are orally administered to animals. On the aspects of bioavailability, the carriers or
- linkers
- do not have that much of an impact at a particular site. With regards to the shelf-life of storing
- the peptide, he suggested that it could be in the form or texture of salt which has durability for
- almost a week. Towards the end, he suggested focusing on the ethical issues associated with the
- disposal of the residue, if any, in the environment and also highlighting the impact being visible
- on human beings, the end consumers of the food chain.</p>
+ <div class="modal fade" id="ihp-modal-11" tabindex="-1" aria-labelledby="ihp-modal-11Label" aria-hidden="true"
+ style="width: 100%;">
+ <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
+ <div class="modal-content">
+ <div class="modal-header">
+ <h3 class="modal-title reveal-on-scroll" id="ihp-modal-11Label">Dr. Manickam G</h3>
+ <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
+ </div>
+ <div class="modal-body">
+ <div class="row">
+ <div class="col-4">
+ <div class="row">
<figure class="figure reveal-on-scroll">
- <img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-dr-manickam-august.jpg"
- class="figure-img img-fluid rounded" alt="Interaction with Dr. Manickam G">
+ <img src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-dr-manickam-g-portrait.jpeg"
+ class="figure-img img-fluid rounded"
+ alt="Dr. Manickam, Research Director, Discovery Chemistry, Bangalore, India.">
<figcaption class="figure-caption text-center">
- Interaction with Dr. Manickam G
+ Dr. Manickam, Research Director, Discovery Chemistry, Bangalore, India.
</figcaption>
</figure>
- <p class="reveal-on-scroll">
- <h5>OUR INFERENCE</h5>
- The interaction with Dr. Manickam gave us a better understanding of implementation of appropriate
- purification methods for commercial production and for the isolation of our peptide using modern
- techniques. This helped us formulate the best fit peptide production using a synthetic approach.
- It
- also made us consider the peptide stability condition through salt formation at room temperature
- or
- an elevated temperature.
- </p>
</div>
</div>
+ <div class="col-8">
+ <p class="reveal-on-scroll">
+ <h5>THEIR INPUT</h5> We interacted with Dr. Manickam on 12th August 2022, to receive inputs on the
+ economic viability and large-scale production of our peptide. He was impressed with our usage of
+ chitosan nanoparticles as a delivery system since it is a natural polymer with immunomodulatory
+ properties and is biodegradable, too. He suggested that we increment the length of our peptide
+ that
+ would help boost our large-scale production. Through this, the purification cost would decrease
+ and
+ the ideal stability conditions and formulation required for the same would be at a more convenient
+ level. This drastically decreases the volume, making our solution more convenient for biological
+ maintenance. He mentioned that the current methods include the biological-based drugs and proteins
+ that are orally administered to animals. On the aspects of bioavailability, the carriers or
+ linkers
+ do not have that much of an impact at a particular site. With regards to the shelf-life of storing
+ the peptide, he suggested that it could be in the form or texture of salt which has durability for
+ almost a week. Towards the end, he suggested focusing on the ethical issues associated with the
+ disposal of the residue, if any, in the environment and also highlighting the impact being visible
+ on human beings, the end consumers of the food chain.</p>
+ <figure class="figure reveal-on-scroll">
+ <img src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-dr-manickam-august.jpg"
+ class="figure-img img-fluid rounded" alt="Interaction with Dr. Manickam G">
+ <figcaption class="figure-caption text-center">
+ Interaction with Dr. Manickam G
+ </figcaption>
+ </figure>
+ <p class="reveal-on-scroll">
+ <h5>OUR INFERENCE</h5>
+ The interaction with Dr. Manickam gave us a better understanding of implementation of appropriate
+ purification methods for commercial production and for the isolation of our peptide using modern
+ techniques. This helped us formulate the best fit peptide production using a synthetic approach.
+ It
+ also made us consider the peptide stability condition through salt formation at room temperature
+ or
+ an elevated temperature.
+ </p>
+ </div>
</div>
</div>
</div>
@@ -1402,66 +1564,56 @@
</div>
<!-- Person-12 -->
- <div class="row">
- <!-- Button trigger modal -->
- <button type="button" class="btn btn-primary" data-bs-toggle="modal" data-bs-target="#ihp-modal-12">
- Reiss Jones
- </button>
-
- <!-- Modal -->
- <div class="modal fade" id="ihp-modal-12" tabindex="-1" aria-labelledby="ihp-modal-12Label" aria-hidden="true"
- style="width: 100%;">
- <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
- <div class="modal-content">
- <div class="modal-header">
- <h3 class="modal-title reveal-on-scroll" id="ihp-modal-12Label">Reiss Jones</h3>
- <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
- </div>
- <div class="modal-body">
- <div class="row">
- <div class="col-4">
- <div class="row">
- <figure class="figure reveal-on-scroll">
- <img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-mr-reiss-jones-portrait.jpg"
- class="figure-img img-fluid rounded" alt="Reiss Jones">
- <figcaption class="figure-caption text-center">
- Reiss Jones
- </figcaption>
- </figure>
- </div>
- <div class="row">
- <p class="reveal-on-scroll">Reiss is a sustainability-based entrepreneur and has previously
- co-founded two startups.
- </p>
- </div>
- </div>
- <div class="col-8">
- <p class="reveal-on-scroll">
- <h5>THEIR INPUT</h5> We approached Reiss Jones on 16th August 2022 to understand the possible
- entrepreneurial aspects we could incorporate in our project. He was quite intrigued with our
- team's approach for the peptide design and he mentioned the skyrocketing demand for sustainable
- solutions in the industry. We explained to him that the fusion protein we intend to have is to
- increase the stability of the short peptide sequence given their instability. We also gave him a
- gist on our plan of performing interaction studies with MAM7 and our peptide. After arriving at a
- proper understanding of our project, he helped us by connecting with various synthetic biology
- professors and other experts in the field of marine biotechnology.</p>
+ <div class="modal fade" id="ihp-modal-12" tabindex="-1" aria-labelledby="ihp-modal-12Label" aria-hidden="true"
+ style="width: 100%;">
+ <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
+ <div class="modal-content">
+ <div class="modal-header">
+ <h3 class="modal-title reveal-on-scroll" id="ihp-modal-12Label">Reiss Jones</h3>
+ <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
+ </div>
+ <div class="modal-body">
+ <div class="row">
+ <div class="col-4">
+ <div class="row">
<figure class="figure reveal-on-scroll">
- <img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-reiss-jones-august.png"
- class="figure-img img-fluid rounded" alt="Interaction with Reiss Jones">
+ <img src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-mr-reiss-jones-portrait.jpg"
+ class="figure-img img-fluid rounded" alt="Reiss Jones">
<figcaption class="figure-caption text-center">
- Interaction with Reiss Jones
+ Reiss Jones
</figcaption>
</figure>
-
- <p class="reveal-on-scroll">
- <h5>OUR INFERENCE</h5>
- He assisted us in navigating the kind of companies we must reach out to and the aquaculture
- specialists we can approach for better insight on our project and shared a few helpful
- contacts. Furthermore, he assisted us in reaching out to other experts who could be beneficial to
- AMPifin.
</div>
+ <div class="row">
+ <p class="reveal-on-scroll">Reiss is a sustainability-based entrepreneur and has previously
+ co-founded two startups.
+ </p>
+ </div>
+ </div>
+ <div class="col-8">
+ <p class="reveal-on-scroll">
+ <h5>THEIR INPUT</h5> We approached Reiss Jones on 16th August 2022 to understand the possible
+ entrepreneurial aspects we could incorporate in our project. He was quite intrigued with our
+ team's approach for the peptide design and he mentioned the skyrocketing demand for sustainable
+ solutions in the industry. We explained to him that the fusion protein we intend to have is to
+ increase the stability of the short peptide sequence given their instability. We also gave him a
+ gist on our plan of performing interaction studies with MAM7 and our peptide. After arriving at a
+ proper understanding of our project, he helped us by connecting with various synthetic biology
+ professors and other experts in the field of marine biotechnology.</p>
+ <figure class="figure reveal-on-scroll">
+ <img src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-reiss-jones-august.png"
+ class="figure-img img-fluid rounded" alt="Interaction with Reiss Jones">
+ <figcaption class="figure-caption text-center">
+ Interaction with Reiss Jones
+ </figcaption>
+ </figure>
+
+ <p class="reveal-on-scroll">
+ <h5>OUR INFERENCE</h5>
+ He assisted us in navigating the kind of companies we must reach out to and the aquaculture
+ specialists we can approach for better insight on our project and shared a few helpful
+ contacts. Furthermore, he assisted us in reaching out to other experts who could be beneficial to
+ AMPifin.
</div>
</div>
</div>
@@ -1470,81 +1622,73 @@
</div>
<!-- Person-13 -->
- <div class="row">
- <!-- Button trigger modal -->
- <button type="button" class="btn btn-primary" data-bs-toggle="modal" data-bs-target="#ihp-modal-13">
- Ronald Kevin D’Souza
- </button>
-
- <!-- Modal -->
- <div class="modal fade" id="ihp-modal-13" tabindex="-1" aria-labelledby="ihp-modal-13Label" aria-hidden="true"
- style="width: 100%;">
- <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
- <div class="modal-content">
- <div class="modal-header">
- <h3 class="modal-title reveal-on-scroll" id="ihp-modal-13Label">Ronald Kevin D’Souza</h3>
- <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
- </div>
- <div class="modal-body">
- <div class="row">
- <div class="col-4">
- <div class="row">
- <figure class="figure reveal-on-scroll">
- <img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-mr-ronald-d-souza-portrait.jpg"
- class="figure-img img-fluid rounded"
- alt="Ronald Kevin D’Souza, owner of Aquatic Biosystems, Mangalore, India.">
- <figcaption class="figure-caption text-center">
- Ronald Kevin D’Souza, owner of Aquatic Biosystems, Mangalore, India.
- </figcaption>
- </figure>
- </div>
- </div>
- <div class="col-8">
- <p class="reveal-on-scroll">
- <h5>THEIR INPUT</h5>We visited Aquatic Biosystems in Mangalore, owned by Mr. Ronald D’Souza on
- 22nd
- August 2022. He set up Aquatic Biosystems in 2006, which is currently the largest ornamental fish
- farm in
- the state of Karnataka and the country’s most scientifically developed ornamental fish farm. He
- explained his journey of setting up the farm and why he chose to use intensive systems, despite
- the
- general preference of using extensive methods for traditional fish farming. He conducts imports
- and
- exports from countries like Germany and Netherlands. He mentioned the procedures involved in the
- Recirculatory Aquaculture System (RAS) filter system for aeration using filters. However, a common
- problem their farm faces is the slow stream of water due to electric power issues in India. The
- general protocol they follow involves quarantining the fish to identify and prevent any diseases
- in
- the hatchery for the breeding methods. Additionally, he mentioned that 5 grams per 100 litres of
- tetracycline is added to the farming unit. The feed added includes fresh blanched meat and dry
- granular feed. Fish feeding schedule at the larval stage is five times per day, and in the adult
- stage, the fish are fed two times per day. The monsoon season enhances the production rate with
- higher export value, simultaneously increasing susceptibility to diseases. The optimum pH
- maintained
- in their breeding unit ranges from 6.5 to 7.2. In case of any increased pH condition, alum is
- added
- to balance it out, and in case of any decreased pH range, the oyster shells are utilised as a
- buffer.
- </p>
+ <div class="modal fade" id="ihp-modal-13" tabindex="-1" aria-labelledby="ihp-modal-13Label" aria-hidden="true"
+ style="width: 100%;">
+ <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
+ <div class="modal-content">
+ <div class="modal-header">
+ <h3 class="modal-title reveal-on-scroll" id="ihp-modal-13Label">Ronald Kevin D’Souza</h3>
+ <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
+ </div>
+ <div class="modal-body">
+ <div class="row">
+ <div class="col-4">
+ <div class="row">
<figure class="figure reveal-on-scroll">
<img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/aquatic-biosystems-outreach-1.jpg"
- class="figure-img img-fluid rounded" alt="Interaction with Ronald Kevin D’Souza">
+ src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-mr-ronald-d-souza-portrait.jpg"
+ class="figure-img img-fluid rounded"
+ alt="Ronald Kevin D’Souza, owner of Aquatic Biosystems, Mangalore, India.">
<figcaption class="figure-caption text-center">
- Interaction with Ronald Kevin D’Souza
+ Ronald Kevin D’Souza, owner of Aquatic Biosystems, Mangalore, India.
</figcaption>
</figure>
- <p class="reveal-on-scroll">
- <h5>OUR INFERENCE</h5>
- We were delighted to observe the application of filters in the fish farm. This gave us the
- confidence to propose a future implementation of our project in the form of a mesh that the inlet
- of
- the fish tank would be subjected to. The parameters provided by him formed a basis for our factors
- into consideration when searching for an appropriate delivery mechanism.
- </p>
</div>
</div>
+ <div class="col-8">
+ <p class="reveal-on-scroll">
+ <h5>THEIR INPUT</h5>We visited Aquatic Biosystems in Mangalore, owned by Mr. Ronald D’Souza on
+ 22nd
+ August 2022. He set up Aquatic Biosystems in 2006, which is currently the largest ornamental fish
+ farm in
+ the state of Karnataka and the country’s most scientifically developed ornamental fish farm. He
+ explained his journey of setting up the farm and why he chose to use intensive systems, despite
+ the
+ general preference of using extensive methods for traditional fish farming. He conducts imports
+ and
+ exports from countries like Germany and Netherlands. He mentioned the procedures involved in the
+ Recirculatory Aquaculture System (RAS) filter system for aeration using filters. However, a common
+ problem their farm faces is the slow stream of water due to electric power issues in India. The
+ general protocol they follow involves quarantining the fish to identify and prevent any diseases
+ in
+ the hatchery for the breeding methods. Additionally, he mentioned that 5 grams per 100 litres of
+ tetracycline is added to the farming unit. The feed added includes fresh blanched meat and dry
+ granular feed. Fish feeding schedule at the larval stage is five times per day, and in the adult
+ stage, the fish are fed two times per day. The monsoon season enhances the production rate with
+ higher export value, simultaneously increasing susceptibility to diseases. The optimum pH
+ maintained
+ in their breeding unit ranges from 6.5 to 7.2. In case of any increased pH condition, alum is
+ added
+ to balance it out, and in case of any decreased pH range, the oyster shells are utilised as a
+ buffer.
+ </p>
+ <figure class="figure reveal-on-scroll">
+ <img
+ src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/aquatic-biosystems-outreach-1.jpg"
+ class="figure-img img-fluid rounded" alt="Interaction with Ronald Kevin D’Souza">
+ <figcaption class="figure-caption text-center">
+ Interaction with Ronald Kevin D’Souza
+ </figcaption>
+ </figure>
+ <p class="reveal-on-scroll">
+ <h5>OUR INFERENCE</h5>
+ We were delighted to observe the application of filters in the fish farm. This gave us the
+ confidence to propose a future implementation of our project in the form of a mesh that the inlet
+ of
+ the fish tank would be subjected to. The parameters provided by him formed a basis for our factors
+ into consideration when searching for an appropriate delivery mechanism.
+ </p>
+ </div>
</div>
</div>
</div>
@@ -1552,69 +1696,61 @@
</div>
<!-- Person-14 -->
- <div class="row">
- <!-- Button trigger modal -->
- <button type="button" class="btn btn-primary" data-bs-toggle="modal" data-bs-target="#ihp-modal-14">
- Miroslav Gasparek
- </button>
-
- <!-- Modal -->
- <div class="modal fade" id="ihp-modal-14" tabindex="-1" aria-labelledby="ihp-modal-14Label" aria-hidden="true"
- style="width: 100%;">
- <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
- <div class="modal-content">
- <div class="modal-header">
- <h3 class="modal-title reveal-on-scroll" id="ihp-modal-14Label">Miroslav Gasparek</h3>
- <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
- </div>
- <div class="modal-body">
- <div class="row">
- <div class="col-4">
- <div class="row">
- <figure class="figure reveal-on-scroll">
- <img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-mr-miroslav-gasparek-portrait.jpg"
- class="figure-img img-fluid rounded" alt="Mr. Miroslav Gasparek">
- <figcaption class="figure-caption text-center">
- Mr. Miroslav Gasparek
- </figcaption>
- </figure>
- </div>
- <div class="row">
- <p class="reveal-on-scroll">Mr. Miroslav Gasparek is a Bioengineer, Entrepreneur, and Researcher.
- He is also a Co-founder
- at Stealth Biotech Startup and a Co-Managing Director
- at Nucleate UK.
- </p>
- </div>
- </div>
- <div class="col-8">
- <p class="reveal-on-scroll">
- <h5>THEIR INPUT</h5>We interacted with Miroslav Gasparek on 26th September 2022, who provided our
- team
- with insights on the biosafety and biosecurity aspects revolving around our project and synthetic
- biology as well. The interaction with him led to have major conversations on how Genetically
- Modified Organisms (GMOs) play a crucial role in the current emerging field of synthetic biology
- </p>
+ <div class="modal fade" id="ihp-modal-14" tabindex="-1" aria-labelledby="ihp-modal-14Label" aria-hidden="true"
+ style="width: 100%;">
+ <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
+ <div class="modal-content">
+ <div class="modal-header">
+ <h3 class="modal-title reveal-on-scroll" id="ihp-modal-14Label">Miroslav Gasparek</h3>
+ <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
+ </div>
+ <div class="modal-body">
+ <div class="row">
+ <div class="col-4">
+ <div class="row">
<figure class="figure reveal-on-scroll">
<img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-miroslav-gasparek-september.png"
- class="figure-img img-fluid rounded" alt="Interaction with Miroslav Gasparek">
+ src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-mr-miroslav-gasparek-portrait.jpg"
+ class="figure-img img-fluid rounded" alt="Mr. Miroslav Gasparek">
<figcaption class="figure-caption text-center">
- Interaction with Miroslav Gasparek
+ Mr. Miroslav Gasparek
</figcaption>
</figure>
- <p class="reveal-on-scroll">
- <h5>OUR INFERENCE</h5>
- We were pleasantly surprised by the immediate conceptual grasp he exhibited regarding our project.
- We incurred valuable insight on the various aspects of biosafety, good lab practices and
- biosecurity
- that play a crucial role in the field of synthetic biology. Given his area of expertise, he
- questioned the gravity of our problem. This helped us string our research-work toward a more
- impact-oriented approach, while also ensuring a safe and sustainable workflow of AMPifin.
+ </div>
+ <div class="row">
+ <p class="reveal-on-scroll">Mr. Miroslav Gasparek is a Bioengineer, Entrepreneur, and Researcher.
+ He is also a Co-founder
+ at Stealth Biotech Startup and a Co-Managing Director
+ at Nucleate UK.
</p>
</div>
</div>
+ <div class="col-8">
+ <p class="reveal-on-scroll">
+ <h5>THEIR INPUT</h5>We interacted with Miroslav Gasparek on 26th September 2022, who provided our
+ team
+ with insights on the biosafety and biosecurity aspects revolving around our project and synthetic
+ biology as well. The interaction with him led to have major conversations on how Genetically
+ Modified Organisms (GMOs) play a crucial role in the current emerging field of synthetic biology
+ </p>
+ <figure class="figure reveal-on-scroll">
+ <img
+ src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-miroslav-gasparek-september.png"
+ class="figure-img img-fluid rounded" alt="Interaction with Miroslav Gasparek">
+ <figcaption class="figure-caption text-center">
+ Interaction with Miroslav Gasparek
+ </figcaption>
+ </figure>
+ <p class="reveal-on-scroll">
+ <h5>OUR INFERENCE</h5>
+ We were pleasantly surprised by the immediate conceptual grasp he exhibited regarding our project.
+ We incurred valuable insight on the various aspects of biosafety, good lab practices and
+ biosecurity
+ that play a crucial role in the field of synthetic biology. Given his area of expertise, he
+ questioned the gravity of our problem. This helped us string our research-work toward a more
+ impact-oriented approach, while also ensuring a safe and sustainable workflow of AMPifin.
+ </p>
+ </div>
</div>
</div>
</div>
@@ -1622,86 +1758,78 @@
</div>
<!-- Person-15 -->
- <div class="row">
- <!-- Button trigger modal -->
- <button type="button" class="btn btn-primary" data-bs-toggle="modal" data-bs-target="#ihp-modal-15">
- Dr. Vinod Jyothikumar
- </button>
-
- <!-- Modal -->
- <div class="modal fade" id="ihp-modal-15" tabindex="-1" aria-labelledby="ihp-modal-15Label" aria-hidden="true"
- style="width: 100%;">
- <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
- <div class="modal-content">
- <div class="modal-header">
- <h3 class="modal-title reveal-on-scroll" id="ihp-modal-15Label">Dr. Vinod Jyothikumar</h3>
- <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
- </div>
- <div class="modal-body">
- <div class="row">
- <div class="col-4">
- <div class="row">
- <figure class="figure reveal-on-scroll">
- <img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-dr-vinod-jyothikumar-portait.jpg"
- class="figure-img img-fluid rounded" alt="Dr. Vinod Jyothikumar">
- <figcaption class="figure-caption text-center">
- Dr. Vinod Jyothikumar
- </figcaption>
- </figure>
- </div>
- <div class="row">
- <p class="reveal-on-scroll">Dr. Vinod Jyothikumar, currently working as a Operations Management
- Consultant in a
- consulting
- firm.
- </p>
- </div>
- </div>
- <div class="col-8">
- <p class="reveal-on-scroll">
- <h5>THEIR INPUT</h5>We interacted with Dr. Vinod Jyothikumar on 28th September 2022 to receive
- inputs on
- the biosafety aspects associated with our project and how we have integrated synthetic biology
- aspects to make it a viable practical application. He suggested we use PubMed graphs for tracking
- the horizontal transfer of pathogenicity of the <i>Vibrio</i> species which turned out to be
- milder.
- Since <i>Vibrio parahaemolyticus</i> is an important human pathogen according to WHO
- guidelines, Dr. Vinod suggested we analyse the risk assessment factors associated with it. We
- mentioned that for further testing, since our project involves a BSL2 pathogen, our approach is to
- express Multivalent Adhesion Molecule 7 (MAM7) in <i>Escherichia coli</i>. He highlighted the
- biochemistry and biophysics aspects involved in making our peptide more commercially realistic
- </p>
- <p class="reveal-on-scroll">He spoke about how we could include a visual signal for our binding by
- making use of a GFP. He
- asked us about the parameters that affect the pathogenicity of <i>Vibrio parahaemolyticus</i>,
- such that we could derive an ideal condition that renders this bacteria harmless. For the
- His-tag
- pull-down mechanism, he spoke about using quantum dots with Nickel coating. These conditions can
- include yellow or green wavelength along with Nickel, and once the carrier is ready, it could be
- treated in the lab to observe the quantum dots under the slide microscope where it glows. He
- urged
- us to include a visual proof of the MAM7 and peptide interaction. The major application of
- visualising, would involve methods of integration of quantum dots. </p>
+ <div class="modal fade" id="ihp-modal-15" tabindex="-1" aria-labelledby="ihp-modal-15Label" aria-hidden="true"
+ style="width: 100%;">
+ <div class="modal-dialog modal-fullscreen ihp-lab-modal-dialog modal-dialog-centered modal-dialog-scrollable">
+ <div class="modal-content">
+ <div class="modal-header">
+ <h3 class="modal-title reveal-on-scroll" id="ihp-modal-15Label">Dr. Vinod Jyothikumar</h3>
+ <button type="button" class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button>
+ </div>
+ <div class="modal-body">
+ <div class="row">
+ <div class="col-4">
+ <div class="row">
<figure class="figure reveal-on-scroll">
<img
- src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-dr-vinod-jyothikumar-september.png"
- class="figure-img img-fluid rounded" alt="Interaction with Dr. Vinod Jyothikumar">
+ src="https://static.igem.wiki/teams/4200/wiki/ihp-portraits/ihp-dr-vinod-jyothikumar-portait.jpg"
+ class="figure-img img-fluid rounded" alt="Dr. Vinod Jyothikumar">
<figcaption class="figure-caption text-center">
- Interaction with Dr. Vinod Jyothikumar
+ Dr. Vinod Jyothikumar
</figcaption>
</figure>
- <p class="reveal-on-scroll">
- <h5>OUR INFERENCE</h5>
- The interaction with Dr. Vinod helped us look for a more realistic approach of synthetic-biology
- to
- our project for the binding. As seafood is a major staple diet of South-East tropical parts of
- Asia,
- Dr. Vinod's suggestions assisted us in browsing through how its effects in the market considering
- the socio-economic element such as Environmental, Social, and Governance (ESG) indices.
+ </div>
+ <div class="row">
+ <p class="reveal-on-scroll">Dr. Vinod Jyothikumar, currently working as a Operations Management
+ Consultant in a
+ consulting
+ firm.
</p>
</div>
</div>
+ <div class="col-8">
+ <p class="reveal-on-scroll">
+ <h5>THEIR INPUT</h5>We interacted with Dr. Vinod Jyothikumar on 28th September 2022 to receive
+ inputs on
+ the biosafety aspects associated with our project and how we have integrated synthetic biology
+ aspects to make it a viable practical application. He suggested we use PubMed graphs for tracking
+ the horizontal transfer of pathogenicity of the <i>Vibrio</i> species which turned out to be
+ milder.
+ Since <i>Vibrio parahaemolyticus</i> is an important human pathogen according to WHO
+ guidelines, Dr. Vinod suggested we analyse the risk assessment factors associated with it. We
+ mentioned that for further testing, since our project involves a BSL2 pathogen, our approach is to
+ express Multivalent Adhesion Molecule 7 (MAM7) in <i>Escherichia coli</i>. He highlighted the
+ biochemistry and biophysics aspects involved in making our peptide more commercially realistic
+ </p>
+ <p class="reveal-on-scroll">He spoke about how we could include a visual signal for our binding by
+ making use of a GFP. He
+ asked us about the parameters that affect the pathogenicity of <i>Vibrio parahaemolyticus</i>,
+ such that we could derive an ideal condition that renders this bacteria harmless. For the
+ His-tag
+ pull-down mechanism, he spoke about using quantum dots with Nickel coating. These conditions can
+ include yellow or green wavelength along with Nickel, and once the carrier is ready, it could be
+ treated in the lab to observe the quantum dots under the slide microscope where it glows. He
+ urged
+ us to include a visual proof of the MAM7 and peptide interaction. The major application of
+ visualising, would involve methods of integration of quantum dots. </p>
+ <figure class="figure reveal-on-scroll">
+ <img
+ src="https://static.igem.wiki/teams/4200/wiki/ihp-timeline-pictures/ihp-dr-vinod-jyothikumar-september.png"
+ class="figure-img img-fluid rounded" alt="Interaction with Dr. Vinod Jyothikumar">
+ <figcaption class="figure-caption text-center">
+ Interaction with Dr. Vinod Jyothikumar
+ </figcaption>
+ </figure>
+ <p class="reveal-on-scroll">
+ <h5>OUR INFERENCE</h5>
+ The interaction with Dr. Vinod helped us look for a more realistic approach of synthetic-biology
+ to
+ our project for the binding. As seafood is a major staple diet of South-East tropical parts of
+ Asia,
+ Dr. Vinod's suggestions assisted us in browsing through how its effects in the market considering
+ the socio-economic element such as Environmental, Social, and Governance (ESG) indices.
+ </p>
+ </div>
</div>
</div>
</div>